Shaukat Khanum Memorial Cancer Hospital & Research Centre
Encyclopedia
Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH&RC) is a state-of-the-art cancer
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...

 centre located in Lahore
Lahore
Lahore is the capital of the Pakistani province of Punjab and the second largest city in the country. With a rich and fabulous history dating back to over a thousand years ago, Lahore is no doubt Pakistan's cultural capital. One of the most densely populated cities in the world, Lahore remains a...

, Punjab
Punjab (Pakistan)
Punjab is the most populous province of Pakistan, with approximately 45% of the country's total population. Forming most of the Punjab region, the province is bordered by Kashmir to the north-east, the Indian states of Punjab and Rajasthan to the east, the Pakistani province of Sindh to the...

, Pakistan
Pakistan
Pakistan , officially the Islamic Republic of Pakistan is a sovereign state in South Asia. It has a coastline along the Arabian Sea and the Gulf of Oman in the south and is bordered by Afghanistan and Iran in the west, India in the east and China in the far northeast. In the north, Tajikistan...

. It is a project of the Shaukat Khanum Memorial Trust, which is a charitable organization established under the Societies Registration Act XXI of 1860 of Pakistan. The institution is the brainchild of Pakistani cricket superstar, Imran Khan
Imran Khan
Imran Khan Niazi is a Pakistani politician and former Pakistani cricketer, playing international cricket for two decades in the late twentieth century. After retiring, he entered politics...

. The inspiration came after the death of his mother, Mrs. Shaukat Khanum, from cancer.

Recently, the plans to build the second Shaukat Khanum Memorial Cancer Hospital and Research Centre in Peshawar
Peshawar
Peshawar is the capital of Khyber-Pakhtunkhwa and the administrative center and central economic hub for the Federally Administered Tribal Areas of Pakistan....

 are underway. The construction work for the project is started and the hospital is expected to be functional in about 3 years. Funds are being raised for the cause and the government of Pakhtunkhwa
Pakhtunkhwa
The Pakistani province of Khyber Pakhtunkhwa has been known by a number of names during its existence. In addition to North-West Frontier Province, the official name by which it was known from 1901 to 2010, other names used or proposed for the province include Afghania, Pakhtunistan, Pashtunistan,...

 province has donated 50 Canals of land for the hospital.

Mission statement

To act as a model institution to alleviate the suffering of patients with cancer through the application of modern methods of curative and palliative therapy irrespective of their ability to pay, the education of health care professionals and the public and perform research into the causes and treatment of cancer.

History

Designing and execution of the master plan was overseen by Dr. Nausherwan K. Burki, MB, PhD, FRCP, FCPS, FCCP, of the University of Kentucky Medical Center, Lexington, Kentucky
Kentucky
The Commonwealth of Kentucky is a state located in the East Central United States of America. As classified by the United States Census Bureau, Kentucky is a Southern state, more specifically in the East South Central region. Kentucky is one of four U.S. states constituted as a commonwealth...

, USA in collaboration with an international team of cancer physicians and research workers. Designing and architectural services were provided by Arrasmith, Judd & Rapp, Architects in Health Planning of Louisville, Kentucky, USA. Architectural details were handled by Messrs. Nayyar Ali Dada & Associates of Lahore. Local engineering was performed by Messrs. Progressive Consultants, Lahore. Ground was broken in April 1991 and the hospital opened its doors on December 29, 1994.

Board of Governors

The Hospital is a project of Shaukat Khanum Memorial Trust, a non-profit legal entity established under the laws of Pakistan. The Board of Governors formulates overall policy and consists of bankers, researchers, businessmen and physicians. The Hospital is managed by a professional team from clinical, administrative and nursing backgrounds.

Clinical departments

  • Medicine
    Medicine
    Medicine is the science and art of healing. It encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness....

     Details
  • Surgery
    Surgery
    Surgery is an ancient medical specialty that uses operative manual and instrumental techniques on a patient to investigate and/or treat a pathological condition such as disease or injury, or to help improve bodily function or appearance.An act of performing surgery may be called a surgical...

     Details
  • Anesthesiology Details
  • Medical Oncology Details
  • Pediatric Oncology Details
  • Pharmacy
    Pharmacy
    Pharmacy is the health profession that links the health sciences with the chemical sciences and it is charged with ensuring the safe and effective use of pharmaceutical drugs...

     Details
  • Radiation Oncology Details
  • Nuclear Medicine
    Nuclear medicine
    In nuclear medicine procedures, elemental radionuclides are combined with other elements to form chemical compounds, or else combined with existing pharmaceutical compounds, to form radiopharmaceuticals. These radiopharmaceuticals, once administered to the patient, can localize to specific organs...

     Details
  • Pathology
    Pathology
    Pathology is the precise study and diagnosis of disease. The word pathology is from Ancient Greek , pathos, "feeling, suffering"; and , -logia, "the study of". Pathologization, to pathologize, refers to the process of defining a condition or behavior as pathological, e.g. pathological gambling....

     Details
  • Research
    Research
    Research can be defined as the scientific search for knowledge, or as any systematic investigation, to establish novel facts, solve new or existing problems, prove new ideas, or develop new theories, usually using a scientific method...

     Details
  • Nursing
    Nursing
    Nursing is a healthcare profession focused on the care of individuals, families, and communities so they may attain, maintain, or recover optimal health and quality of life from conception to death....

    Details

Research

Research is needed to develop better ways of detecting and treating cancer and to improve cancer care. Over the coming years, SKMCH&RC's expanding knowledge of cancer genetics will have a major impact on its ability to predict an individual's level of risk of developing cancer, to detect and diagnose cancer early and to select treatments which are most likely to be effective. Ultimately, the genetic revolution may lead to ways of preventing cancer. The genetic revolution provides major opportunities for identifying people at risk of cancer and for developing better treatments. At the moment such studies are limited in Pakistan.

SKMCH&RC's research is organized in three different streams: i) epidemiology, which seeks to understand the lifestyle and environmental causes of cancer; ii) molecular biology, which will enable the development of better ways of predicting treatment responses and disease outcome i.e. molecular markers; and iii) clinical trials, which is primarily focused on the evaluation of existing and new therapies. The Management Information Systems (MIS) Department has developed a state of the art hospital information system. Through this system, the research team has been able to handle the logistics of a large hospital, documenting a wealth of patient information.

SKMCH&RC's objective is to explore the bridge between laboratory and clinic though the support of translational studies in areas of diagnosis, prognosis and treatment. It is important to maintain research concerned with cancer in local population, addressing issues of prevention through studies on the effects of genetic make-up, environment and lifestyle.

The research section has been developed over the last five years, and, recently, received a donation to refurbish the 3rd floor of the Hospital into a Research Wing, housing a suite of research laboratories, a data management and epidemiology division, as well as a clinical research section responsible for clinical trials.

The team of researchers is expanding and several projects are underway. Currently, Basic Sciences Research is divided into three main areas of interest and several projects are being conducted:

(1) Identification of genetic risk factors in the development of cancer
  • Prevalence and spectrum of BRCA1/2 germline mutations in Pakistani Breast and/or Ovarian Cancer families.

  • A study to evaluate the association between germline genetic variation and disease risk and outcome in ovarian carcinoma in Pakistan.

  • The role of p53 mutations in the development, progression and outcome of breast cancer in Pakistan.

  • Genetic causes of colorectal cancer in the Pakistani population.


(2) Tumor virology
  • Human Papillomavirus Associated with Esophageal Cancer in Pakistan - A Retrospective Analysis.

  • Human Papillomavirus in Cervical Cancer cases from Pakistan.

  • Transcriptional profiling of Hodgkin’s Lymphoma; relationship to EBV status, histological subtype and geographical locale.


(3) Infections and cancer
  • PCR assay for detection & quantification of fungal infections in patients with AML, ALL and Myelodysplastic Syndrome.
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