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Seminoma
 
 
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Seminoma is one type of testicular cancer
Testicular cancer

Testicular cancer is cancer that develops in the testicles, a part of the male reproductive system.In the United States, between 7,500 and 8,000 diagnoses of testicular cancer are made each year....
 that is believed to originate from the germinal epithelium
Germinal epithelium (male)

The germinal epithelium is the outermost layer of the testicle....
 of the seminiferous tubules.

produce bulky masses that can be up to ten times the size of a normal testis.

have been proposed as possible markers.

Peak incidence occurs in the 4th decade of life. Histology shows large cells, clear cytoplasm, distinct cell membranes, and septated architecture.

ecent years, these tumors have been shown to have dramatic sensitivity to both radiotherapy and cytotoxic chemotherapy
Chemotherapy

Chemotherapy, in its most general sense, refers to treatment of disease by chemicals that kill cells, specifically those of micro-organisms or cancer....
.






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Seminoma is one type of testicular cancer
Testicular cancer

Testicular cancer is cancer that develops in the testicles, a part of the male reproductive system.In the United States, between 7,500 and 8,000 diagnoses of testicular cancer are made each year....
 that is believed to originate from the germinal epithelium
Germinal epithelium (male)

The germinal epithelium is the outermost layer of the testicle....
 of the seminiferous tubules.

Presentation

They produce bulky masses that can be up to ten times the size of a normal testis.

Diagnosis

and have been proposed as possible markers.

Peak incidence occurs in the 4th decade of life. Histology shows large cells, clear cytoplasm, distinct cell membranes, and septated architecture.

Treatment

In recent years, these tumors have been shown to have dramatic sensitivity to both radiotherapy and cytotoxic chemotherapy
Chemotherapy

Chemotherapy, in its most general sense, refers to treatment of disease by chemicals that kill cells, specifically those of micro-organisms or cancer....
. The management of childhood seminoma is similar to that of adult seminoma. Inguinal orchiectomy
Inguinal orchiectomy

Inguinal orchiectomy is a relatively minor surgery to remove a testicle. The procedure is generally performed by a urologist. Often it is performed as same-day surgery, with the patient returning home within hours of the procedure....
 is required in almost all cases.

Relation to spermatocytic seminoma

Spermatocytic seminoma
Spermatocytic seminoma

In oncology, spermatocytic seminoma is a neoplasm of the testis, and classified as a germ cell tumour.The name of the tumour comes from the similarity between the small cells of the tumour and secondary spermatocytes....
s are not considered a subtype
Subtype

In computer science, a subtype is a datatype that is generally related to another datatype by some notion of substitutability, meaning that computer programs written to operate on elements of the supertype can also operate on elements of the subtype....
 of seminoma and unlike other germ cell tumours do not arise from intratubular germ cell neoplasia
Intratubular germ cell neoplasia

Intratubular germ cell neoplasia, abbreviated ITGCN and also known as testicular intratubular germ cell neoplasia and intratubular germ cell neoplasia of the testis, is considered the precursor lesion for many types of testis germ cell tumours, and can be considered to be a carcinoma in situ....
.

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