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The Science of Aging Knowledge Environment (SAGE KE) is an online scientific
Science

In its broadest sense, science refers to any systematic knowledge or practice. In its more usual restricted sense, science refers to a system of acquiring knowledge based on scientific method, as well as to the organized body of knowledge gained through such research....
 resource provided by the American Association for the Advancement of Science
American Association for the Advancement of Science

The American Association for the Advancement of Science is an international non-profit organization with the stated goals of promoting cooperation between scientists, defending scientific freedom, encouraging scientific responsibility, and supporting science education and science outreach for the betterment of all humanity....
 (AAAS), which also publishes the journal Science
Science (journal)

Science is the academic journal of the American Association for the Advancement of Science and is considered one of the world's most prestigious scientific journals....
.

American Association for the Advancement of Science established a collaboration
Collaboration

Collaboration is a recursive process where two or more people or organizations work together toward an intersection of common goals ? for example, an intellectual endeavor that is creative in nature?by sharing knowledge, learning and building consensus....
 with Stanford University
Stanford University

Leland Stanford Junior University, commonly referred to as Stanford University or Stanford, is a private university research university located in Stanford, California, California, United States....
 Libraries and The Center for Resource Economics/Island Press (Island Press) in 1996 to find means to utilize internet
Internet

The Internet is a global network of interconnected computers, enabling users to share information along multiple channels. Typically, a computer that connects to the Internet can access information from a vast array of available server and other computers by moving information from them to the computer's local memory....
-based technologies to enhance access to scientific information and improve the effectiveness of information transfer.






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The Science of Aging Knowledge Environment (SAGE KE) is an online scientific
Science

In its broadest sense, science refers to any systematic knowledge or practice. In its more usual restricted sense, science refers to a system of acquiring knowledge based on scientific method, as well as to the organized body of knowledge gained through such research....
 resource provided by the American Association for the Advancement of Science
American Association for the Advancement of Science

The American Association for the Advancement of Science is an international non-profit organization with the stated goals of promoting cooperation between scientists, defending scientific freedom, encouraging scientific responsibility, and supporting science education and science outreach for the betterment of all humanity....
 (AAAS), which also publishes the journal Science
Science (journal)

Science is the academic journal of the American Association for the Advancement of Science and is considered one of the world's most prestigious scientific journals....
.

History and Organization

The American Association for the Advancement of Science established a collaboration
Collaboration

Collaboration is a recursive process where two or more people or organizations work together toward an intersection of common goals ? for example, an intellectual endeavor that is creative in nature?by sharing knowledge, learning and building consensus....
 with Stanford University
Stanford University

Leland Stanford Junior University, commonly referred to as Stanford University or Stanford, is a private university research university located in Stanford, California, California, United States....
 Libraries and The Center for Resource Economics/Island Press (Island Press) in 1996 to find means to utilize internet
Internet

The Internet is a global network of interconnected computers, enabling users to share information along multiple channels. Typically, a computer that connects to the Internet can access information from a vast array of available server and other computers by moving information from them to the computer's local memory....
-based technologies to enhance access to scientific information and improve the effectiveness of information transfer. The collaborative coined the term Knowledge Environment (KE) to describe the collection of electronic networking
Computer network

A computer network is a group of interconnected computers. Networks may be classified according to a wide variety of characteristics. This article provides a general overview of some types and categories and also presents the basic components of a network....
 tools they were seeking to develop.

SAGE KE is the third in a series of Knowledge Environments developed by Science and AAAS
American Association for the Advancement of Science

The American Association for the Advancement of Science is an international non-profit organization with the stated goals of promoting cooperation between scientists, defending scientific freedom, encouraging scientific responsibility, and supporting science education and science outreach for the betterment of all humanity....
, after the Signal Transduction
Signal transduction

In biology, 'signal transduction' refers to any process by which a cell converts one kind of signal or stimulus into another. Most processes of signal transduction involve ordered sequences of biochemistry chemical reaction inside the cell, which are carried out by enzymes, activated by Second messenger systems, resulting in a signal tran...
 Knowledge Environment (STKE) and AIDScience. Funding for SAGE KE comes from , founded and supported by Oracle Corporation
Oracle Corporation

Oracle Corporation specializes in developing and marketing enterprise software products ? particularly database management systems. Through organic growth and a number of high-profile acquisitions, Oracle enlarged its share of the software market....
 CEO Larry Ellison
Larry Ellison

Lawrence Joseph "Larry" Ellison is an United States entrepreneur and the co-founder and CEO of Oracle Corporation, a major enterprise software company....
.

SAGE KE published its final issue on 28 June 2006 due to lack of funding. The interactive content was discontinued during the Summer of 2006, leaving the SAGE KE site as an archive by August 2006.

Activities

The focus of SAGE KE was to provide timely access to information about advances on basic mechanisms of aging and age-related disease
Disease

A disease or medical condition is an abnormal condition of an organism that impairs bodily functions, associated with specific symptoms and Medical signs....
s through the internet
Internet

The Internet is a global network of interconnected computers, enabling users to share information along multiple channels. Typically, a computer that connects to the Internet can access information from a vast array of available server and other computers by moving information from them to the computer's local memory....
, to provide searchable database
Database

A database is a structured collection of records or data that is stored in a computer system. The structure is achieved by organizing the data according to a database model....
s of information on aging and to provide an active environment in which biogerontologists
Gerontology

Gerontology is the study of the social, Psychology and Biology aspects of Ageing. It is distinguished from geriatrics, which is the branch of medicine that studies the disease of the elderly....
 could share and debate their understandings.

Ouroboros

Ouroboros is a WordPress
WordPress

WordPress is an open source Weblog software. WordPress is the official successor of b2cafelog which was developed by Michel Valdrighi. The name WordPress was suggested by Christine Selleck, a friend of lead developer Matt Mullenweg....
 community weblog devoted to research in the biology of aging
Senescence

Senescence encompasses all of the biological processes of a living organism's approaching an advanced age . The word senescence is derived from the Latin word senex, meaning "old man" or "old age" or "advanced in age"....
. It was established in July 2006 in reaction to the termination of the SAGE KE. The primary mission of the site is to provide timely commentary and review of recently published articles in the scholarly literature, either directly or indirectly related to aging. Articles on the site discuss a range of scientific topics, including Alzheimer's disease
Alzheimer's disease

Alzheimer's disease , also called Alzheimer disease, Senile Dementia of the Alzheimer Type or simply Alzheimer's, is the most common form of dementia....
, bioinformatics
Bioinformatics

Bioinformatics is the application of information technology to the field of molecular biology. The term bioinformatics was coined by Paulien Hogeweg in 1978 for the study of informatic processes in biotic systems....
, calorie restriction
Calorie restriction

Calorie restriction, or caloric restriction , is a dietary regime thought to improve health and slow the Senescence process by limiting dietary energy intake....
, regulation of gene expression
Gene expression

Gene expression is the process by which inheritable information from a gene, such as the DNA sequence, is made into a functional gene product, such as protein or RNA....
, the role of mitochondria in the aging process, and evolution
Evolution

In biology, evolution is change in the heritability trait of a population of organisms from one generation to the next. These changes are caused by a combination of three main processes: variation, reproduction, and selection....
ary theories of aging.

See also

  • Ageing
    Ageing

    Ageing or aging is the accumulation of changes in an organism or object over time. Aging in humans refers to a multidimensional process of physical, psychological, and social change....
  • American Association for the Advancement of Science
    American Association for the Advancement of Science

    The American Association for the Advancement of Science is an international non-profit organization with the stated goals of promoting cooperation between scientists, defending scientific freedom, encouraging scientific responsibility, and supporting science education and science outreach for the betterment of all humanity....
  • Biogerontology
    Gerontology

    Gerontology is the study of the social, Psychology and Biology aspects of Ageing. It is distinguished from geriatrics, which is the branch of medicine that studies the disease of the elderly....
  • Science (journal)
    Science (journal)

    Science is the academic journal of the American Association for the Advancement of Science and is considered one of the world's most prestigious scientific journals....
  • Senescence
    Senescence

    Senescence encompasses all of the biological processes of a living organism's approaching an advanced age . The word senescence is derived from the Latin word senex, meaning "old man" or "old age" or "advanced in age"....


External links