Roderick MacKinnon
Encyclopedia
Roderick MacKinnon is a professor of Molecular Neurobiology and Biophysics
Biophysics
Biophysics is an interdisciplinary science that uses the methods of physical science to study biological systems. Studies included under the branches of biophysics span all levels of biological organization, from the molecular scale to whole organisms and ecosystems...

 at Rockefeller University
Rockefeller University
The Rockefeller University is a private university offering postgraduate and postdoctoral education. It has a strong concentration in the biological sciences. It is also known for producing numerous Nobel laureates...

 who won the Nobel Prize in Chemistry
Nobel Prize in Chemistry
The Nobel Prize in Chemistry is awarded annually by the Royal Swedish Academy of Sciences to scientists in the various fields of chemistry. It is one of the five Nobel Prizes established by the will of Alfred Nobel in 1895, awarded for outstanding contributions in chemistry, physics, literature,...

 together with Peter Agre
Peter Agre
Peter Agre is an American medical doctor, professor, and molecular biologist who was awarded the 2003 Nobel Prize in Chemistry for his discovery of aquaporins. Aquaporins are water-channel proteins that move water molecules through the cell membrane...

 in 2003 for his work on the structure and operation of ion channel
Ion channel
Ion channels are pore-forming proteins that help establish and control the small voltage gradient across the plasma membrane of cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells...

s.

Early life and education

MacKinnon was born in Burlington, Massachusetts
Burlington, Massachusetts
Burlington is a town in Middlesex County, Massachusetts, United States. The population was 24,498 at the 2010 census.- History :It is believed that Burlington takes its name from the English town of Bridlington, however this has never been confirmed....

 and initially attended the University of Massachusetts Boston
University of Massachusetts Boston
The University of Massachusetts Boston, also known as UMass Boston, is an urban public research university and the second largest campus in the five-campus University of Massachusetts system. The university is located on on Harbor Point in the City of Boston, Massachusetts, United States...

. MacKinnon then transferred to Brandeis University
Brandeis University
Brandeis University is an American private research university with a liberal arts focus. It is located in the southwestern corner of Waltham, Massachusetts, nine miles west of Boston. The University has an enrollment of approximately 3,200 undergraduate and 2,100 graduate students. In 2011, it...

 after one year, and there he received a bachelor's degree in biochemistry
Biochemistry
Biochemistry, sometimes called biological chemistry, is the study of chemical processes in living organisms, including, but not limited to, living matter. Biochemistry governs all living organisms and living processes...

 in 1978, studying calcium
Calcium
Calcium is the chemical element with the symbol Ca and atomic number 20. It has an atomic mass of 40.078 amu. Calcium is a soft gray alkaline earth metal, and is the fifth-most-abundant element by mass in the Earth's crust...

 transport through the cell membrane
Cell membrane
The cell membrane or plasma membrane is a biological membrane that separates the interior of all cells from the outside environment. The cell membrane is selectively permeable to ions and organic molecules and controls the movement of substances in and out of cells. It basically protects the cell...

 for his honors thesis in Christopher Miller's laboratory. It was also at Brandeis where MacKinnon met his future wife and working-colleague Alice Lee.

After receiving his degree from Brandeis, MacKinnon entered medical school at Tufts University
Tufts University
Tufts University is a private research university located in Medford/Somerville, near Boston, Massachusetts. It is organized into ten schools, including two undergraduate programs and eight graduate divisions, on four campuses in Massachusetts and on the eastern border of France...

. He got his M.D. in 1982 and received training in Internal Medicine at Beth Israel Hospital
Beth Israel Deaconess Medical Center
Beth Israel Deaconess Medical Center in Boston, Massachusetts is a major flagship teaching hospital of Harvard Medical School. It was formed out of the 1996 merger of Beth Israel Hospital and New England Deaconess Hospital...

 in Boston. He did not feel satisfied enough with the medical profession, so in 1986 he returned to Christopher Miller's laboratory at Brandeis for postdoctoral studies.

Career

In 1989 he was appointed assistant professor at Harvard University
Harvard University
Harvard University is a private Ivy League university located in Cambridge, Massachusetts, United States, established in 1636 by the Massachusetts legislature. Harvard is the oldest institution of higher learning in the United States and the first corporation chartered in the country...

 where he studied the interaction of the potassium channel
Potassium channel
In the field of cell biology, potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes...

 with a specific toxin derived from scorpion venom, acquainting himself with methods of protein purification and X-ray crystallography
X-ray crystallography
X-ray crystallography is a method of determining the arrangement of atoms within a crystal, in which a beam of X-rays strikes a crystal and causes the beam of light to spread into many specific directions. From the angles and intensities of these diffracted beams, a crystallographer can produce a...

. In 1996 he moved to Rockefeller University
Rockefeller University
The Rockefeller University is a private university offering postgraduate and postdoctoral education. It has a strong concentration in the biological sciences. It is also known for producing numerous Nobel laureates...

 as a professor and head of the Laboratory of Molecular Neurobiology and Biophysics where he started to work on the structure of the potassium channel. These channels are of particular importance to the nervous system
Nervous system
The nervous system is an organ system containing a network of specialized cells called neurons that coordinate the actions of an animal and transmit signals between different parts of its body. In most animals the nervous system consists of two parts, central and peripheral. The central nervous...

 and the heart and enable potassium ions to cross the cell membrane
Cell membrane
The cell membrane or plasma membrane is a biological membrane that separates the interior of all cells from the outside environment. The cell membrane is selectively permeable to ions and organic molecules and controls the movement of substances in and out of cells. It basically protects the cell...

.

Scientific contributions

Potassium channels demonstrate a seemingly counterintuitive activity: they permit the passage of potassium ions, whereas they do not allow the passage of the much smaller sodium
Sodium
Sodium is a chemical element with the symbol Na and atomic number 11. It is a soft, silvery-white, highly reactive metal and is a member of the alkali metals; its only stable isotope is 23Na. It is an abundant element that exists in numerous minerals, most commonly as sodium chloride...

 ions. Before MacKinnon's work, the detailed molecular architecture of potassium channels and the exact means by which they conduct ions remained speculative. In 1998, despite barriers to the structural
Structural biology
Structural biology is a branch of molecular biology, biochemistry, and biophysics concerned with the molecular structure of biological macromolecules, especially proteins and nucleic acids, how they acquire the structures they have, and how alterations in their structures affect their function...

 study of integral membrane protein
Integral membrane protein
An integral membrane protein is a protein molecule that is permanently attached to the biological membrane. Proteins that cross the membrane are surrounded by "annular" lipids, which are defined as lipids that are in direct contact with a membrane protein...

s that had thwarted most attempts for decades, MacKinnon and colleagues determined the three-dimensional molecular structure of a potassium channel from bacteria utilizing X-ray crystallography
X-ray crystallography
X-ray crystallography is a method of determining the arrangement of atoms within a crystal, in which a beam of X-rays strikes a crystal and causes the beam of light to spread into many specific directions. From the angles and intensities of these diffracted beams, a crystallographer can produce a...

. With this structure and other biochemical experiments, MacKinnon and colleagues were able to explain the exact mechanism by which potassium channel selectivity occurs.

His prize-winning research was conducted primarily at the Cornell High Energy Synchrotron Source
Cornell High Energy Synchrotron Source
The Cornell Laboratory for Accelerator-based Sciences and Education is a particle accelerator facility located in Wilson Laboratory on the Cornell University campus in Ithaca, NY. CLASSE formed from the merger of the Cornell High-Energy Synchrotron Source and the Laboratory for...

 (CHESS) of Cornell University
Cornell University
Cornell University is an Ivy League university located in Ithaca, New York, United States. It is a private land-grant university, receiving annual funding from the State of New York for certain educational missions...

, and at the National Synchrotron Light Source
National Synchrotron Light Source
The National Synchrotron Light Source at Brookhaven National Laboratory in Upton, New York is a national user research facility funded by the U.S. Department of Energy...

 (NSLS) of Brookhaven National Laboratory
Brookhaven National Laboratory
Brookhaven National Laboratory , is a United States national laboratory located in Upton, New York on Long Island, and was formally established in 1947 at the site of Camp Upton, a former U.S. Army base...

.

Awards and distinctions

  • 1997 - Newcomb Cleveland Prize
    Newcomb Cleveland Prize
    The Newcomb Cleveland Prize of the American Association for the Advancement of Science is annually awarded to author of outstanding scientific paper published in the Research Articles or Reports sections of Science...

  • 1998 - W. Alden Spencer Award
  • 1999 - Albert Lasker Award for Basic Medical Research
    Albert Lasker Award for Basic Medical Research
    The Albert Lasker Award for Basic Medical Research is one of the prizes awarded by the Lasker Foundation for the understanding, diagnosis, prevention, treatment, and cure of disease...

  • 2000 - Elected to the U.S. National Academy of Sciences
    United States National Academy of Sciences
    The National Academy of Sciences is a corporation in the United States whose members serve pro bono as "advisers to the nation on science, engineering, and medicine." As a national academy, new members of the organization are elected annually by current members, based on their distinguished and...

  • 2000 - Rosenstiel Award
    Rosenstiel Award
    In 1971, the Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research was established as an expression of the conviction that educational institutions have an important role to play in the encouragement and development of basic science as it applies to medicine.Medals are...

  • 2001 - Gairdner Foundation International Award
    Gairdner Foundation International Award
    The Gairdner Foundation International Award is given annually at a special dinner to three to six people for outstanding discoveries or contributions to medical science. Receipt of the Gairdner is traditionally considered a precursor to winning the Nobel Prize in Medicine; as of 2007, 69 Nobel...

  • 2003 - Louisa Gross Horwitz Prize
    Louisa Gross Horwitz Prize
    Louisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers that have made an outstanding contribution in basic research in the fields of biology or biochemistry....

     from Columbia University
    Columbia University
    Columbia University in the City of New York is a private, Ivy League university in Manhattan, New York City. Columbia is the oldest institution of higher learning in the state of New York, the fifth oldest in the United States, and one of the country's nine Colonial Colleges founded before the...

  • 2003 - Nobel Prize in Chemistry
    Nobel Prize in Chemistry
    The Nobel Prize in Chemistry is awarded annually by the Royal Swedish Academy of Sciences to scientists in the various fields of chemistry. It is one of the five Nobel Prizes established by the will of Alfred Nobel in 1895, awarded for outstanding contributions in chemistry, physics, literature,...


External links

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