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Rheumatology



 
 
Rheumatology is a sub-specialty in internal medicine
Internal medicine

Internal Medicine is the medical specialty concerned with the diagnosis, management and nonsurgical treatment of unusual or serious diseases. In North America, specialists in internal medicine are commonly called, "Internists." Elsewhere, especially in Commonwealth of Nations nations, such specialists are often called Physicians....
 and pediatrics
Pediatrics

Differences between adult and pediatric medicinePediatrics differs from adult medicine in many respects. The obvious body size differences are paralleled by maturational changes....
, devoted to the diagnosis
Diagnosis

Diagnosis is the identification of the nature of anything, either by process of elimination or other analytical methods. Diagnosis is used in many different disciplines, with slightly different implementations on the application of logic and experience to determine the cause and effect relationships....
 and therapy of rheumatic diseases. Rheumatologists mainly deal with clinical problems involving joints, soft tissues and allied conditions of connective tissues. The term rheumatology originates from the Greek word rheuma, meaning "that which flows as a river or stream" and the suffix -ology, meaning "the study of."

Rheumatology is a rapidly evolving medical specialty; new scientific discoveries related to this specialty are largely related to better understanding of immunology of these disorders.






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Rheumatology is a sub-specialty in internal medicine
Internal medicine

Internal Medicine is the medical specialty concerned with the diagnosis, management and nonsurgical treatment of unusual or serious diseases. In North America, specialists in internal medicine are commonly called, "Internists." Elsewhere, especially in Commonwealth of Nations nations, such specialists are often called Physicians....
 and pediatrics
Pediatrics

Differences between adult and pediatric medicinePediatrics differs from adult medicine in many respects. The obvious body size differences are paralleled by maturational changes....
, devoted to the diagnosis
Diagnosis

Diagnosis is the identification of the nature of anything, either by process of elimination or other analytical methods. Diagnosis is used in many different disciplines, with slightly different implementations on the application of logic and experience to determine the cause and effect relationships....
 and therapy of rheumatic diseases. Rheumatologists mainly deal with clinical problems involving joints, soft tissues and allied conditions of connective tissues. The term rheumatology originates from the Greek word rheuma, meaning "that which flows as a river or stream" and the suffix -ology, meaning "the study of."

Rheumatology is a rapidly evolving medical specialty; new scientific discoveries related to this specialty are largely related to better understanding of immunology of these disorders. Pathogenesis of major rheumatological disorders is now described as autoimmune disorders. Immunology explains pathogenesis and the characteristics of rheumatological disorders, and most of the new treatment modalities are based on immunology. Better understanding of genetic bases of rheumatological disorders makes rheumatology a specialty rapidly developing as a medical specialty based on new scientific discoveries. New treatment modalities are based on scientific research on immunology
Immunology

Immunology is a broad branch of biomedical science science that covers the study of all aspects of the immune system in all organisms. It deals with, among other things, the physiology functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders ; the physical, chemical an...
, cytokine
Cytokine

Cytokines are a category of signaling molecules that, like hormones and neurotransmitters, are used extensively in cell communication. They are proteins, peptides or glycoproteins....
s, T lymphocytes, B lymphocytes and future therapies may be directed more towards gene therapy as well.

Currently, practice of rheumatology is largely based on clinical research, evidence based medical treatment of rheumatological disorders has helped patients with rheumatism
Rheumatism

Rheumatism or Rheumatic disorder is a non-specific term for medical problems affecting the heart, bones, joints, kidney, skin and lung. The study of, and therapeutic interventions in, such disorders is called rheumatology....
 lead a near normal life without any disabilities. Clinicians who specialize in rheumatology are called Rheumatologists.

Rheumatism


Rheumatism is a non-specific term used to describe any painful disorder affecting the loco-motor system including joints, muscle
MUSCLE

MUSCLE is public domain, multiple sequence alignment software for protein and nucleotide sequences.MUSCLE is integrated into UGENE bioinformatics tool as a plugin....
s, connective tissue
Connective tissue

Connective tissue is a form of fibrous biological tissue.It is one of the four types of tissue in traditional classifications .Collagen is the main protein of connective tissue in animals and the most abundant protein in mammals, making up about 25% of the total protein content....
s, soft tissue
Soft tissue

In medicine, the term soft tissue refers to Tissue that connect, support, or surround other structures and Organ s of the body.Soft tissue includes tendons, ligaments, fascia, Fibrous connective tissue, fat, and synovial membranes , and muscles, nerves and blood vessels ....
s around the joints and bones. The term rheumatism is also used to describe rheumatic fever affecting heart valves. However, the medical profession use specific terms to describe rheumatological disorders such as rheumatoid arthritis
Rheumatoid arthritis

Rheumatoid arthritis is a chronic, systemic disease inflammation that may affect many tissues and organs, but principally attacks the joints producing a inflammatory synovitis that often progresses to destruction of the articular cartilage and ankylosis of the joints....
, ankylosing spondylitis
Ankylosing spondylitis

Ankylosing spondylitis It is a member of the group of the spondyloarthropathy with a strong genetic predisposition. Complete fusion results in a complete rigidity of the spine, a condition known as bamboo spine....
, gout
Gout

Gout is a crystal deposition disease hallmarked by elevated levels of uric acid in the Circulatory system. In this condition, crystals of monosodium urate or uric acid are deposited on the articular cartilage of joints, tendons and surrounding tissues....
 and systemic lupus erythematosus
Systemic lupus erythematosus

Systemic lupus erythematosus is a chronic Autoimmunity connective tissue disease that can affect any part of the body. As occurs in other autoimmune diseases, the immune system attacks the body?s cells and tissue, resulting in inflammation and tissue damage....
 and so on in the medical literature.

Rheumatology is now emerging as an important clinical specialty recognized all over the world. This speciality is rapidly improving and well established along with properly organized post graduate training programs. The term describing clinicians dealing with rheumatism as "Rheumatologists" is now a well established term commonly used by the medical community, even though it is not adequately described in dictionaries established for languages. Rheumatologists all over the world are now capable of treating most of the chronic rheumatological disorders with a much better outcome for the patients. This is due to the discovery of new disease modifying agents called biologics which is now a well established form of treatment for the patients suffering with chronic and disabling joint disorders. A large proportion of patients with rheumatoid arthritis, up to seventy percent according to some studies, can now be cured with the introduction and wide spread use of biologic treatment for arthritic disorders since the beginning of twenty first century.

Rheumatologist

Rheumatologist. (Consultant Rheumatologist.)

A rheumatologist is a clinician specialized in the field of medical sub-specialty called rheumatology, and holds either a Doctor of Medicine
Doctor of Medicine

Doctor of Medicine is a Doctorate for physicians . The degree is granted from medical schools.It is a first professional degree in some countries, including the United States and Canada, although training is entered after obtaining at least 90 hours of university level work ....
 Degree (M.D.) or a Doctor of Osteopathy degree (D.O.). Training in this field requires four years undergraduate school, four years of medical school, and then, in the United States, three years of residency, followed by two or three years additional Fellowship training. The number of years allocated for specialized training in rheumatology for postgraduate trainees in different countries could vary according to the requirements of different countries. Rheumatologists are internists, physicians or pediatricians who are qualified by additional postgraduate training and experience in the diagnosis and treatment of arthritis and other diseases of the joints, muscles and bones. Many rheumatologists also conduct research to determine the cause and better treatments for these disabling and sometimes fatal diseases. Treatment modalities are based on scientific research, currently, practice of rheumatology is largely evidence based. Clinicians who specialize on this specialty are called Rheumatologists.

Rheumatologists treat arthritis
Arthritis

Arthritis is a group of conditions involving damage to the joints of the body. Arthritis is the leading cause of disability in people older than fifty-five years....
, certain autoimmune diseases, musculoskeletal pain disorders and osteoporosis
Osteoporosis

Osteoporosis is a disease of bone that leads to an increased risk of bone fracture. In osteoporosis the bone mineral density is reduced, bone microarchitecture is disrupted, and the amount and variety of collagen proteins in bone is altered....
. There are more than 200 types of these diseases, including rheumatoid arthritis
Rheumatoid arthritis

Rheumatoid arthritis is a chronic, systemic disease inflammation that may affect many tissues and organs, but principally attacks the joints producing a inflammatory synovitis that often progresses to destruction of the articular cartilage and ankylosis of the joints....
, osteoarthritis
Osteoarthritis

Osteoarthritis , is a group of diseases and mechanical abnormalities entailing degradation of joints, including articular cartilage and the subchondral bone next to it....
, gout
Gout

Gout is a crystal deposition disease hallmarked by elevated levels of uric acid in the Circulatory system. In this condition, crystals of monosodium urate or uric acid are deposited on the articular cartilage of joints, tendons and surrounding tissues....
, lupus
Lupus

Lupus may refer to:...
, back pain, osteoporosis, fibromyalgia
Fibromyalgia

Fibromyalgia , meaning muscle and connective tissue pain , is a disorder classified by the presence of chronic widespread pain and a heightened and painful response to gentle Somatosensory system ....
 and tendinitis. Some of these are very serious diseases that can be difficult to diagnose and treat. They treat soft tissue problems related to musculoskeletal system sports related soft tissue disorders and the specialty is also interrelated with physiotherapy, physical medicine and rehabilitation of disabled patients. Patient education programs and occupational therapy also go hand in hand with this specialty.

There are many international organizations representing rheumatologists all over the world. The American College of Rheumatology
American College of Rheumatology

The American College of Rheumatology is an organization of and for physicians, health professionals, and scientists that advances rheumatology through programs of education, research, advocacy and practice support that foster excellence in the care of people with arthritis and rheumatic and musculoskeletal diseases....
 ( ACR), the European League Against Rheumatism
European League Against Rheumatism

The European League Against Rheumatism is an international organisation in the field of rheumatology. The society publishes a medical journal, the Annals of the Rheumatic Diseases, and organises an annual scientific meeting, the Annual European Congress of Rheumatology....
 (EULAR), Asia Pacific League of Associations for Rheumatology
Asia Pacific League of Associations for Rheumatology

Asia Pacific League of Associations for Rheumatology APLAR is the Asia Pacific League of Associations for Rheumatology. APLAR is an organization of Rheumatologists, Physicians, Allied Health Professionals, and Scientists that advances rheumatology through programs of education, research, advocacy and practice support that foster excellence...
 (APLAR), International League of Associations for Rheumatology (ILAR) are the main international organizations established and organizing many activities related to this specialty, these organizations strive to propagate and consolidate Rheumatology endeavors internationally , furthermore, there are associations and colleges of Rheumatology representing Rheumatologists from each and every nation scattered throughout the world which represent the above mentioned organizations from each nation. Rheumatologists are physicians specialized in rheumatic diseases.

For example, there are approximately 480 consultant rheumatologists in the UK. Rheumatologists are increasing in numbers in all countries, as there is an increasing demand for specialists on this field with an increasing population of aging patients who need specialized treatment.

Diseases

Diseases diagnosed or managed by the rheumatologist include:

  • Rheumatoid arthritis
    Rheumatoid arthritis

    Rheumatoid arthritis is a chronic, systemic disease inflammation that may affect many tissues and organs, but principally attacks the joints producing a inflammatory synovitis that often progresses to destruction of the articular cartilage and ankylosis of the joints....
  • Lupus
    Systemic lupus erythematosus

    Systemic lupus erythematosus is a chronic Autoimmunity connective tissue disease that can affect any part of the body. As occurs in other autoimmune diseases, the immune system attacks the body?s cells and tissue, resulting in inflammation and tissue damage....
  • Sjögren's syndrome
    Sjögren's syndrome

    Sj?gren's syndrome is an autoimmunity in which immune cells attack and destroy the exocrine glands that produce tears and saliva.It is named after Swedish ophthalmology Henrik Sj?gren , who first described it....
  • scleroderma
    Scleroderma

    Systemic scleroderma is a systemic connective tissue disease.It is also known as "systemic Sclerosis "....
     (systemic sclerosis)
  • dermatomyositis
    Dermatomyositis

    Dermatomyositis is a connective-tissue disease related to Polymyositis that is characterized by inflammation of the muscles and the skin....
  • polychondritis
    Polychondritis

    Relapsing polychondritis is a condition where cartilage deteriorates.It is also known as Chronic atrophic polychondritis, Meyenburg-Altherr-Uehlinger syndrome, von Meyenburg's disease, Generalized chondromalacia, or Systemic chondromalacia....
  • polymyositis
    Polymyositis

    Polymyositis is a type of chronic inflammatory myopathy, related to dermatomyositis and inclusion body myositis. Polymyositis means 'many muscle inflammation'....
  • polymyalgia rheumatica
    Polymyalgia rheumatica

    Polymyalgia rheumatica , abbreviated as PMR, is an inflammatory condition of the muscles, which causes pain or stiffness, usually in the neck, shoulders, and Hip ....
  • osteoarthritis
    Osteoarthritis

    Osteoarthritis , is a group of diseases and mechanical abnormalities entailing degradation of joints, including articular cartilage and the subchondral bone next to it....
  • septic arthritis
    Septic arthritis

    Septic arthritis is the purulent invasion of a joint by an infectious agent which produces arthritis....
  • fibromyalgia
    Fibromyalgia

    Fibromyalgia , meaning muscle and connective tissue pain , is a disorder classified by the presence of chronic widespread pain and a heightened and painful response to gentle Somatosensory system ....
  • sarcoidosis
    Sarcoidosis

    Sarcoidosis, also called sarcoid or Besnier-Boeck disease, is a multisystem disorder characterized by non-caseating granulomas . It most commonly arises in young adults....
  • gout
    Gout

    Gout is a crystal deposition disease hallmarked by elevated levels of uric acid in the Circulatory system. In this condition, crystals of monosodium urate or uric acid are deposited on the articular cartilage of joints, tendons and surrounding tissues....
    , pseudogout
  • spondyloarthropathies
    Spondyloarthropathy

    Spondyloarthropathies are inflammatory joint diseases of the vertebral column associated with the Major_histocompatibility_complex class I molecule HLA-B27....
    • ankylosing spondylitis
      Ankylosing spondylitis

      Ankylosing spondylitis It is a member of the group of the spondyloarthropathy with a strong genetic predisposition. Complete fusion results in a complete rigidity of the spine, a condition known as bamboo spine....
    • reactive arthritis
      Reactive arthritis

      Reactive arthritis is an autoimmune condition that develops in response to an infection in another part of the body. Coming into contact with bacteria and developing an infection can trigger reactive arthritis....
    • psoriatic arthropathy
    • enteropathic spondylitis
    • reactive arthropathy
  • vasculitis
    Vasculitis

    Vasculitis refers to a heterogeneous group of disorders that are characterized by inflammatory destruction of blood vessels.Both arteries and veins are affected....
    • polyarteritis nodosa
      Polyarteritis nodosa

      Polyarteritis nodosa is a vasculitis of medium-sized arteries, which become swollen and damaged from attack by rogue immune cells. Polyarteritis nodosa is also called Adolph Kussmaul disease or Kussmaul-Rudolf Robert Meier disease....
    • Henoch-Schönlein purpura
      Henoch-Schönlein purpura

      Henoch-Sch?nlein purpura, also known as allergic purpura or anaphylactoid purpura and commonly abbreviated to HSP, is a systemic vasculitis characterized by deposition of immune complexes containing the antibody IgA in the skin and kidney....
    • serum sickness
      Serum sickness

      Serum sickness is a reaction to proteins in antiserum derived from an animal source. It is a type of hypersensitivity, specifically immune complex hypersensitivity ....
    • Wegener's granulomatosis
      Wegener's granulomatosis

      Wegener's granulomatosis is a form of vasculitis that affects the lungs, kidneys and other organs. Due to its end-organ damage, it can be a serious disease that requires long-term immune suppression....
    • giant cell arteritis
    • temporal arteritis
      Temporal arteritis

      Giant cell arteritis is an inflammation disease of blood vessels . It a form of vasculitis.The name reflects the type of inflammatory cell that is involved ....
    • Takayasu's arteritis
      Takayasu's arteritis

      Takayasu's arteritis is an inflammation of unknown etiology that affects the aorta and its branches. Although it has been reported worldwide, it shows a predilection for young Asian people women....
    • Behçet's syndrome
    • Kawasaki's disease (mucocutaneous lymph node syndrome)
    • Buerger's disease
      Buerger's disease

      Buergers's disease is an acute inflammation and thrombosis of artery and veins of the hands and feet. It is strongly associated with use of tobacco products, primarily from Tobacco smoking, but also from smokeless tobacco....
       (thromboangiitis obliterans)


Juvenile Idiopathic Arthritis(JIA) ;

( JIA inccudes a wide range Joint Disoders affecting Children)

Rheumatic arthritis;

Soft Tissue Rheumatism; ( Localizes diseases and lesions affecting the joints and structures around the joints including tendons ,ligaments capsules, bursae, Stress Fractures, muscles , nerve entrapment, vascular lesions , ganglion, connective tissue abnormalities and localised Soft tissues disorders etc.)

Diseases affecting bones;

Osteoporosis, osteomalasia, renal osteodystrophy, Fluorosis, Rickets Etc.

Congenital and familial Disorders affecting Joints;

Hyperextensible joints;

Ehlers-Danlos Syndrome,Achondroplasisa, Marfan's Syndrome etc.

Diagnosis

Apart from an extensive medical history, there are useful methods of diagnosis both performed easy enough in a physical examination
Physical examination

File:Reeve 978.jpgPhysical examination or clinical examination is the process by which a health care provider investigates the body of a patient for sign of disease....
 and, on the other hand, more complicated ones, often requiring a rheumatologist or other specialised physicians.

Physical examination

Following are examples of methods of diagnosis able to be performed in a normal physical examination.
  • Schober's test
    Schober's test

    Schober's test is a test used in rheumatology to measure the ability of a patient to flex his/her lower back....
     tests the flexion of the lower back.


Specialised

  • Laboratory
    Medical laboratory

    A medical laboratory or clinical laboratory is a laboratory where tests are done on clinical specimens in order to get information about the health of a patient....
     tests
    Blood test

    A blood test is a medical laboratory analysis performed on a blood sample that is usually extracted from a vein in the arm using a hypodermic needle, or via fingerprick....
     (e.g. Erythrocyte Sedimentation Rate
    Erythrocyte sedimentation rate

    The erythrocyte sedimentation rate , also called a sedimentation rate or Biernacki Reaction, is the rate at which red blood cells precipitate in a period of 1 hour....
    , Rheumatoid Factor
    Rheumatoid factor

    Rheumatoid factor is an autoantibody most relevant in rheumatoid arthritis. It is an antibody against the Fc portion of IgG, which is itself an antibody....
    , Anti-CCP( Anti-Cyclic Citrullinated Peptide antibody), ANA (Anti-Nuclear Antibody)
    Anti-nuclear antibody

    Anti-nuclear antibodies are antibody directed against contents of the cell nucleus.They are present in higher than normal numbers in autoimmune disease....
     )
  • X-ray
    X-ray

    X-radiation is a form of electromagnetic radiation. X-rays have a wavelength in the range of 10 to 0.01 nanometers, corresponding to frequency in the range 30 Hertz to 30 Hertz and energies in the range 120 Electron volt to 120 keV....
    s of affected joints and other imaging methods
  • Cytology
    Cytology

    Cytology means "the study of cell s".Cytology is that branch of life science, which deals with the study of cells in terms of structure, function and chemistry....
     and chemical pathology of fluid aspirated from affected joints (e.g. to differentiate between septic arthritis
    Septic arthritis

    Septic arthritis is the purulent invasion of a joint by an infectious agent which produces arthritis....
     and gout
    Gout

    Gout is a crystal deposition disease hallmarked by elevated levels of uric acid in the Circulatory system. In this condition, crystals of monosodium urate or uric acid are deposited on the articular cartilage of joints, tendons and surrounding tissues....
    )


Treatment

Most rheumatic diseases are treated with analgesic
Analgesic

An analgesic is any member of the diverse group of Medication used to relieve pain . The word analgesic derives from Greek an- and algos ....
s, NSAIDs (Non-Steroid Anti-Inflammatory Drugs), steroid
Steroid

A steroid is a terpenoid lipid characterized by a carbon skeleton with four fused rings, generally arranged in a 6-6-6-5 fashion.Steroids vary by the functional groups attached to these rings and the oxidation state of the rings....
s (in serious cases), DMARDs (Disease-Modifying Anti-Rheumatic Drugs), monoclonal antibodies, such as infliximab
Infliximab

Infliximab is a drug used to treat autoimmune List of autoimmune diseases. Infliximab is known as a "chimeric monoclonal antibody" . The drug blocks the action of the pleiotropic proinflammatory TNFa by binding to it and preventing it from signaling the receptor for TNFa on the surface of cell ....
 and adalimumab
Adalimumab

Adalimumab is the third TNF inhibitor, after infliximab and etanercept, to be approved in the United States. Like infliximab and etanercept, adalimumab binds to Tumor necrosis factor-alpha, preventing it from activating TNF receptors; adalimumab was constructed from a fully human monoclonal antibody, while infliximab is a mouse-human Chimer...
, and the soluble TNF receptor etanercept
Etanercept

Etanercept is a drug that treats autoimmune diseases by interfering with the CD120, a part of the immune system.Etanercept is a recombinant-DNA drug made by combining two proteins ....
. Biologic agent Rituximab (Anti-B-Cell Therapy) is now licensed for use in refractory Rheumatoid Arthritis. .

Physiotherapy is vital in the treatment of many rheumatological disorders. Occupational therapy
Occupational therapy

File:Occupational therapy psychiatric hospital.jpgOccupational Therapy, often abbreviated as "OT", incorporates meaningful and purposeful occupation to enable people with limitations or impairments to participate in everyday life....
 can help patients finding alternative ways for common movements which would otherwise be restricted by their disease. Patients with rheumatoid arthritis often need a long term, coordinated and a multidisciplinary team approach towards management of individual patients, treatment is often tailored according the individual needs of the individual patient which is also dependent on the response and the tolerability of medications.

Scientific research

Recently, a large body of scientific research deals with the background of autoimmune disease
Autoimmune disease

Autoimmune diseases arise from an overactive immune response of the body against substances and tissues normally present in the body. In other words, the body attacks its own cells....
, the cause of many rheumatic disorders. Also, the field of osteoimmunology
Osteoimmunology

Osteoimmunology is the study of the interface between the skeleton and the immune system, comprising the ?osteo-immune system?. It is also the study of shared components and mechanisms between the two systems in vertebrates, including ligands, receptors, signaling molecules and transcription factors....
 has emerged to further examine the interactions between the immune system, joints and bones. Epidemiological studies and medication trials are also being conducted. Scientific research on biologics and clinical trials on monoclonal antibody therapies have added a new dimension to the medical treatment of arthritic disorders.

External links

  • .
  • -Cutting edge commentary and analysis in the field of Rheumatology