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Retinoic acid receptor alpha

Retinoic acid receptor alpha

Overview
Retinoic acid receptor alpha (RAR-alpha), also known as NR1B1 (nuclear receptor subfamily 1, group B, member 1) is a nuclear receptor
Nuclear receptor
In the field of molecular biology, nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules...

 encoded by the gene.
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Encyclopedia
Retinoic acid receptor alpha (RAR-alpha), also known as NR1B1 (nuclear receptor subfamily 1, group B, member 1) is a nuclear receptor
Nuclear receptor
In the field of molecular biology, nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules...

 encoded by the gene.

Interactions


Retinoic acid receptor alpha has been shown to interact
Protein-protein interaction
Protein-protein interactions involve not only the direct-contact association of protein molecules but also longer range interactions through the electrolyte, aqueous solution medium surrounding neighbor hydrated proteins over distances from less than one nanometer to distances of several tens of...

 with NCOA6
NCOA6
Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.-Interactions:NCOA6 has been shown to interact with Ku70, RBBP5, E2F1, Retinoblastoma protein, CREB binding protein, Activating transcription factor 2, HSF1, HBXIP, TGS1, TUBB, TUBA4A, Thyroid hormone receptor...

, CLOCK
CLOCK
Circadian Locomotor Output Cycles Kaput, or Clock is a gene which encodes proteins regulating circadian rhythm. The CLOCK protein seems to affect both the persistence and length of the circadian cycle. CLOCK forms part of a basic-helix-loop-helix transcription factor...

, TADA3L
TADA3L
Transcriptional adapter 3-like is a protein that in humans is encoded by the TADA3 gene.-Interactions:TADA3L has been shown to interact with Retinoic acid receptor alpha, USP5, TAF9, Transcription initiation protein SPT3 homolog, TADA2L and Retinoid X receptor alpha.-Further reading:...

, Zinc finger and BTB domain-containing protein 16
Zinc finger and BTB domain-containing protein 16
Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene.- Function :This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the...

, Src
Src (gene)
Src is a family of proto-oncogenic tyrosine kinases originally discovered by J. Michael Bishop and Harold E. Varmus, for which they won the 1989 Nobel Prize in Physiology or Medicine...

, Nuclear receptor related 1 protein
Nuclear receptor related 1 protein
The Nuclear receptor related 1 protein is a member of the nuclear receptor family of intracellular transcription factors and is encoded by the gene ....

, Small heterodimer partner
Small heterodimer partner
The small heterodimer partner protein is a member of the nuclear receptor family of intracellular transcription factors and is encoded by the gene. SHP is unusual for a nuclear receptor in that it lacks a DNA binding domain...

, NPAS2
NPAS2
Neuronal PAS domain-containing protein 2 is a protein that in humans is encoded by the NPAS2 gene.-Interactions:NPAS2 has been shown to interact with Retinoic acid receptor alpha, EP300, ARNTL and Retinoid X receptor alpha....

, Cyclin D3, Nuclear receptor co-repressor 1
Nuclear receptor co-repressor 1
The nuclear receptor co-repressor 1 is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. In addition, NCOR1 appears to recruit histone deacetylases to DNA promoter regions...

, BAG1
BAG1
BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene.BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer's...

, Nuclear receptor co-repressor 2
Nuclear receptor co-repressor 2
The nuclear receptor co-repressor 2 is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR2 assists nuclear receptors in the down regulation of target...

, NRIP1
NRIP1
Nuclear receptor-interacting protein 1 is a protein that in humans is encoded by the NRIP1 gene.Knockout mice that completely lack the RIP140 molecule are lean and stay lean, even on a rich diet...

, Promyelocytic leukemia protein
Promyelocytic leukemia protein
Probable transcription factor PML is a protein that in humans is encoded by the PML gene.-Interactions:Promyelocytic leukemia protein has been shown to interact with Retinoic acid receptor alpha, HDAC1, Nerve Growth factor IB, SKI protein, Zinc finger and BTB domain-containing protein 16, Cyclin...

 and Retinoid X receptor alpha
Retinoid X receptor alpha
Retinoid X receptor alpha , also known as NR2B1 is a nuclear receptor which in humans is encoded by the RXRA gene....

.