Phosphoribosylglycinamide formyltransferase
Encyclopedia
Trifunctional purine biosynthetic protein adenosine-3 is an enzyme
that in humans is encoded by the GART gene
.
This protein is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase
(EC 6.3.4.13), phosphoribosylglycinamide synthetase
(EC 6.3.3.1), phosphoribosylaminoimidazole synthetase
(EC 2.1.2.2) activity which is required for de novo purine
biosynthesis.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the GART gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
This protein is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase
Phosphoribosylamine-glycine ligase
In enzymology, a phosphoribosylamine-glycine ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, 5-phospho-D-ribosylamine, and glycine, whereas its 3 products are ADP, phosphate, and N1-glycinamide.This enzyme belongs to the family of ligases,...
(EC 6.3.4.13), phosphoribosylglycinamide synthetase
AIR synthetase (FGAM cyclase)
AIR synthetase is the fifth enzyme in the de novo synthesis of purine nucleotides. It catalyzes the reaction to form 5-aminoimidizole ribonucleotide from formylglycinamidine-ribonucleotide FGAM. This reaction closes the ring and produces a 5-membered imidazole ring of the purine nucleus . AIR...
(EC 6.3.3.1), phosphoribosylaminoimidazole synthetase
Phosphoribosylaminoimidazole synthetase
In the field of enzymology, phosphoribosylaminoimidazole synthetase is an enzyme that catalyzes the chemical reaction:This enzyme is required for the de novo biosynthesis of purines....
(EC 2.1.2.2) activity which is required for de novo purine
Purine
A purine is a heterocyclic aromatic organic compound, consisting of a pyrimidine ring fused to an imidazole ring. Purines, including substituted purines and their tautomers, are the most widely distributed kind of nitrogen-containing heterocycle in nature....
biosynthesis.