Pharyngeal slit
Encyclopedia
Pharyngeal slits are filter-feeding organs found in non-vertebrate
chordates (lancelets and tunicates) and hemichordates living in aquatic environments. These repeated segments are controlled by similar developmental mechanisms. Some hemichordate species can have as many as 200 gill slits. Pharyngeal slits resembling gill slits are transiently present during the embryonic stages of tetrapod
development. The presence of gill-like slits in the neck of the developing human embryo famously led Earnst Haeckel to postulate that "ontogeny recapitulates phylogeny"; this hypothesis, while false, contains elements of truth, as explored by Stephen Jay Gould in Ontogeny and Phylogeny. However, it is now accepted that it is the vertebrate pharyngeal pouches and not the neck slits that are homologous to the pharyngeal slits of invertebrate chordates. Gill slits are, at some stage of life, found in all chordates.
, which develop using the same genetic pathways involved in oral jaw formation.
. With the placement of hemichordates and echinoderms as a sister group to chordates, a new hypothesis has emerged-suggesting that pharyngeal gill slits were present in the deuterostome
ancestor . Intriguingly, extant echinoderms lack pharyngeal structures, but fossil records reveal that ancestral forms of echinoderms had gill-like structures.
Comparative developmental and genetic studies of these pharyngeal structures between hemichordates and urochordates have brought about important insights regarding the evolution of the deuterostome body plan
. Comparative molecular biology has revealed that the Pax1/9 genes (which encode for transcription factors) are expressed in similar patterns between hemichordates and urochordates; In vertebrates, Pax 1 and Pax 9 are expressed in the pharyngeal pouches and are important for thymus
development. Interestingly applying excess retinoic acid
(excess retincoic acid in vertebrates results in pharyngeal abnormalities) leads to the absence of gill slits in developing Amphioxus, suggesting that retinoic acid may act through the same mechanism in vertebrates and amphioxus. These studies indicate that the pharyngeal slits found in hemichordates and chordates are indeed homologous in a molecular sense.
Vertebrate
Vertebrates are animals that are members of the subphylum Vertebrata . Vertebrates are the largest group of chordates, with currently about 58,000 species described. Vertebrates include the jawless fishes, bony fishes, sharks and rays, amphibians, reptiles, mammals, and birds...
chordates (lancelets and tunicates) and hemichordates living in aquatic environments. These repeated segments are controlled by similar developmental mechanisms. Some hemichordate species can have as many as 200 gill slits. Pharyngeal slits resembling gill slits are transiently present during the embryonic stages of tetrapod
Tetrapod
Tetrapods are vertebrate animals having four limbs. Amphibians, reptiles, birds and mammals are all tetrapods; even snakes and other limbless reptiles and amphibians are tetrapods by descent. The earliest tetrapods evolved from the lobe-finned fishes in the Devonian...
development. The presence of gill-like slits in the neck of the developing human embryo famously led Earnst Haeckel to postulate that "ontogeny recapitulates phylogeny"; this hypothesis, while false, contains elements of truth, as explored by Stephen Jay Gould in Ontogeny and Phylogeny. However, it is now accepted that it is the vertebrate pharyngeal pouches and not the neck slits that are homologous to the pharyngeal slits of invertebrate chordates. Gill slits are, at some stage of life, found in all chordates.
Pharyngeal arches in Vertebrates
In vertebrates, the pharyngeal arches are derived from all three germ layers. Neural crest cells enter these arches where they contribute to craniofacial features such as bone and cartilage. However, the existence of pharyngeal structures before neural crest cells evolved is indicated by the existence of neural crest-independent mechanisms of pharyngeal arch development. The first, most anterior pharyngeal arch gives rise to the oral jaw. The second arch becomes the hyoid and jaw support . In fish, the other posterior arches contribute to the brachial skeleton, which support the gills; in tetrapods the anterior arches develop into components of the ear, tonsils, and thymus. The genetic and developmental basis of pharyngeal arch development is well characterized. It has been shown that Hox genes and other developmental genes such as dlx are important for patterning the anterior/posterior and dorsal/ventral axes of the branchial arches. Interestingly, some fish species have jaws in their throat, known as pharyngeal jawsPharyngeal jaws
Pharyngeal jaws are a "second set" of jaws contained within an animal's throat, or pharynx, distinct from the primary jaws. They are believed to have originated as modified gill arches, in much the same way as oral jaws....
, which develop using the same genetic pathways involved in oral jaw formation.
Evolution of pharyngeal slits
The presence of pharyngeal slits in hemichordates led to debates of whether this structure was homologous to the slits found in chordates or a result of convergent evolutionConvergent evolution
Convergent evolution describes the acquisition of the same biological trait in unrelated lineages.The wing is a classic example of convergent evolution in action. Although their last common ancestor did not have wings, both birds and bats do, and are capable of powered flight. The wings are...
. With the placement of hemichordates and echinoderms as a sister group to chordates, a new hypothesis has emerged-suggesting that pharyngeal gill slits were present in the deuterostome
Deuterostome
Deuterostomes are a superphylum of animals. They are a subtaxon of the Bilateria branch of the subregnum Eumetazoa, and are opposed to the protostomes...
ancestor . Intriguingly, extant echinoderms lack pharyngeal structures, but fossil records reveal that ancestral forms of echinoderms had gill-like structures.
Comparative developmental and genetic studies of these pharyngeal structures between hemichordates and urochordates have brought about important insights regarding the evolution of the deuterostome body plan
Body plan
A body plan is the blueprint for the way the body of an organism is laid out. An organism's symmetry, its number of body segments and number of limbs are all aspects of its body plan...
. Comparative molecular biology has revealed that the Pax1/9 genes (which encode for transcription factors) are expressed in similar patterns between hemichordates and urochordates; In vertebrates, Pax 1 and Pax 9 are expressed in the pharyngeal pouches and are important for thymus
Thymus
The thymus is a specialized organ of the immune system. The thymus produces and "educates" T-lymphocytes , which are critical cells of the adaptive immune system....
development. Interestingly applying excess retinoic acid
Retinoic acid
Retinoic acid is a metabolite of vitamin A that mediates the functions of vitamin A required for growth and development. Retinoic acid is required in chordate animals which includes all higher animals from fishes to humans...
(excess retincoic acid in vertebrates results in pharyngeal abnormalities) leads to the absence of gill slits in developing Amphioxus, suggesting that retinoic acid may act through the same mechanism in vertebrates and amphioxus. These studies indicate that the pharyngeal slits found in hemichordates and chordates are indeed homologous in a molecular sense.