Pericentriolar material
Encyclopedia
Pericentriolar material is an amorphous mass of protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 which makes up the part of the centrosome
Centrosome
In cell biology, the centrosome is an organelle that serves as the main microtubule organizing center of the animal cell as well as a regulator of cell-cycle progression. It was discovered by Edouard Van Beneden in 1883...

 that surrounds the two centriole
Centriole
A Centriole is a barrel-shaped cell structure found in most animal eukaryotic cells, though it is absent in higher plants and most fungi. The walls of each centriole are usually composed of nine triplets of microtubules...

s. The PCM contains proteins responsible for microtubule nucleation
Microtubule nucleation
Microtubules are filaments of the cytoskeleton. They typically form through the polymerization of α- and β-tubulin dimers elongating existing microtubules...

 and anchoring including γ-tubulin
Tubulin
Tubulin is one of several members of a small family of globular proteins. The most common members of the tubulin family are α-tubulin and β-tubulin, the proteins that make up microtubules. Each has a molecular weight of approximately 55 kiloDaltons. Microtubules are assembled from dimers of α- and...

, pericentrin and ninein.

According to the Gene Ontology
Gene Ontology
The Gene Ontology, or GO, is a major bioinformatics initiative to unify the representation of gene and gene product attributes across all species...

, the following human
Human
Humans are the only living species in the Homo genus...

 proteins are associated with the PCM http://amigo.geneontology.org/cgi-bin/amigo/term-assoc.cgi?gptype=all&speciesdb=all&taxid=9606&evcode=all&term_assocs=all&term=GO%3A0000242&session_id=8778amigo1254139139&action=filter:
  • BBS4
    BBS4
    Bardet-Biedl syndrome 4 protein is a protein that in humans is encoded by the BBS4 gene.This gene encodes a protein which contains tetratricopeptide repeats , similar to O-linked N-acetylglucosamine transferase. Mutations in this gene have been observed in patients with Bardet-Biedl syndrome type 4...

    , Bardet-Biedl syndrome 4 protein
  • Lck
    Lck
    Lck is a protein that is found inside specialized cells of the immune system called lymphocytes. Lck is a tyrosine kinase, which phosphorylates tyrosine residues of certain proteins involved in the intracellular signaling pathways of these lymphocytes...

    , Proto-oncogene tyrosine-protein kinase LCK
  • PCM1
    PCM1
    Pericentriolar material 1, also known as PCM1, is a protein which in humans is encoded by the PCM1 gene.- Function :The PCM1 protein was originally identified by virtue of its distinct cell cycle-dependent association with the centrosome complex and microtubules. The protein appears to associate...

    , Pericentriolar material 1 protein
  • TNKS
    TNKS
    Tankyrase-1 is an enzyme that in humans is encoded by the TNKS gene.-Interactions:TNKS has been shown to interact with MCL1, TNKS1BP1, FNBP1 and TERF1.-Further reading:...

    , Tankyrase-1
  • TNKS2
    TNKS2
    Tankyrase-2 is an enzyme that in humans is encoded by the TNKS2 gene.-Interactions:TNKS2 has been shown to interact with GRB14, TERF1 and Cystinyl aminopeptidase.-Further reading:...

    , Tankyrase-2
  • TUBE1, Tubulin
    Tubulin
    Tubulin is one of several members of a small family of globular proteins. The most common members of the tubulin family are α-tubulin and β-tubulin, the proteins that make up microtubules. Each has a molecular weight of approximately 55 kiloDaltons. Microtubules are assembled from dimers of α- and...

    epsilon chain
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