Numt
Encyclopedia
Numt is an abbreviated term for “nuclear mitochondrial
DNA”, which describes any transfer or “transposition” of cytoplasmic mitochondrial DNA sequences into the separate nuclear genome of a eukaryotic organism. As whole genome sequencing projects accumulate, more and more Numts have been detected in many diverse eukaryotic organisms (see http://www.pseudogene.net for one list of examples).
The first use of the term was made to describe a transposition of approximately 7.9 kilobase pairs of the cytoplasmic mtDNA genome into the nucleus of the domestic cat (Felis silvestris catus), where Numt is tandemly repeated, 38-76 times at a single genomic locus on cat chromosome D2. Many Numts are transcriptionally inactive similar to some satellite (or junk) DNA, though they may be considered as part of the Serial Endosymbiosis Theory (SET) or endosymbiotic theory
for the origin of eukaryotic cells and organelles.
Mitochondrion
In cell biology, a mitochondrion is a membrane-enclosed organelle found in most eukaryotic cells. These organelles range from 0.5 to 1.0 micrometers in diameter...
DNA”, which describes any transfer or “transposition” of cytoplasmic mitochondrial DNA sequences into the separate nuclear genome of a eukaryotic organism. As whole genome sequencing projects accumulate, more and more Numts have been detected in many diverse eukaryotic organisms (see http://www.pseudogene.net for one list of examples).
The first use of the term was made to describe a transposition of approximately 7.9 kilobase pairs of the cytoplasmic mtDNA genome into the nucleus of the domestic cat (Felis silvestris catus), where Numt is tandemly repeated, 38-76 times at a single genomic locus on cat chromosome D2. Many Numts are transcriptionally inactive similar to some satellite (or junk) DNA, though they may be considered as part of the Serial Endosymbiosis Theory (SET) or endosymbiotic theory
Endosymbiotic theory
The endosymbiotic theory concerns the mitochondria, plastids , and possibly other organelles of eukaryotic cells. According to this theory, certain organelles originated as free-living bacteria that were taken inside another cell as endosymbionts...
for the origin of eukaryotic cells and organelles.