Negative selection: Facts, Discussion Forum, and Encyclopedia Article

Negative selection

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	Negative selection
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	Negative selection may refer to: In biology: Negative selection (natural selection) Negative selection (natural selection) Negative selection, in natural selection, is the selective removal of alleles that are Mutation#Harmful_mutations. This can result in stabilizing selection through the purging of deleterious variations that arise.... , in natural selection it refers to the selective removal of rare alleles that are deleterious. Negative selection (artificial selection) Negative selection (artificial selection) In artificial selection, negative selection is where negative, rather than positive, traits of a species are selected for evolutionary continuance.... , in artificial selection it refers to where negative, rather than positive, traits of a species are selected for. In politics: Negative selection (politics) Negative selection (politics) Negative selection, in politics, is a process that occurs in rigid hierarchy, most notably dictatorships.The person on the top of the hierarchy, wishing to remain in power forever, chooses his associates with the prime criterion of incompetence - they must not be competent enough to remove him from power.... , is a process that occurs in rigid hierarchies, most notably dictatorships. In immunology: Negative selection (immunology) T-cells that recognize self MHC molecules (and peptides) with high affinity are deleted from the repertoire of cells. Central tolerance Central tolerance Central tolerance is the mechanism by which newly developing T cells and B cells are rendered non-reactive to self. Central tolerance is distinct from periphery tolerance in that it occurs while cells are still present in the primary lymphoid organs , prior to export into the periphery, while peripheral tolerance is generated after the cells... is produced. Avoids auto-immunity. Occurs after positive selection.