Neddylation
Encyclopedia
Neddylation is the process by which the ubiquitin
Ubiquitin
Ubiquitin is a small regulatory protein that has been found in almost all tissues of eukaryotic organisms. Among other functions, it directs protein recycling.Ubiquitin can be attached to proteins and label them for destruction...

 like protein Nedd8 is conjugated to its target proteins. This process is analogous to ubiquitin
Ubiquitin
Ubiquitin is a small regulatory protein that has been found in almost all tissues of eukaryotic organisms. Among other functions, it directs protein recycling.Ubiquitin can be attached to proteins and label them for destruction...

ation, although relies on its own E1 and E2 enzymes. No Nedd8-specific E3 has yet been identified and it is possible that the Neddylation system relies on E3 ligases with dual specificity.

NEDD8

Neural-precursor-cell-expressed developmentally down-regulated 8 is involved in the regulation of cell growth, viability and development.

Disease association

Neddylation is involved in the pathogenesis of Alzheimer's Disease
Alzheimer's disease
Alzheimer's disease also known in medical literature as Alzheimer disease is the most common form of dementia. There is no cure for the disease, which worsens as it progresses, and eventually leads to death...

 where its activation appears to drive neurons into apoptosis
Apoptosis
Apoptosis is the process of programmed cell death that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation...

 by initiating cell cycle
Cell cycle
The cell cycle, or cell-division cycle, is the series of events that takes place in a cell leading to its division and duplication . In cells without a nucleus , the cell cycle occurs via a process termed binary fission...

reentry.
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