Mycobacterium montefiorense
Encyclopedia
Mycobacterium montefiorense has been demonstrated to be an etiologic agent of a granulomatous skin disease of moray eel
Moray eel
Moray eels are cosmopolitan eels of the family Muraenidae. The approximately 200 species in 15 genera are almost exclusively marine, but several species are regularly seen in brackish water and a few, for example the freshwater moray can sometimes be found in freshwater...

s. Sequence analysis, of the 16S rRNA gene reveals M. montefiorense is most closely related to Mycobacterium triplex
Mycobacterium triplex
Mycobacterium triplex is a species of Mycobacterium.It is closely related to Mycobacterium genavense.It causes disease in immunocompromised patients....

, an opportunistic pathogen of humans.

M. montefiorense was named after the Montefiore Medical Center
Montefiore Medical Center
Montefiore Medical Center, in the Bronx, New York, is the University Hospital for the Albert Einstein College of Medicine. The hospital, named for Moses Montefiore, is one of the 50 largest employers in New York State . In 2011, Montefiore Medical Center was ranked as #6 of the 180 New York City...

, Bronx, N.Y., the medical institution where it was isolated.

Description

Microscopy reveals beaded acid-fast rods from growth on Middlebrook 7H10 media at 25°C

The colony characteristics are such that growth from Middlebrook 7H10 media at 25°C has small and transparent, slow growing, nonchromogenic colonies.

The physiology is such that it does not grow at temperatures of >30°C.

The differential characteristics are the following:
  • Unique 16S rRNA gene with its closest match being M. triplex
  • Sequences of the hsp65 amplicon demonstrated that M. montefiorense differs from M. triplex by 10 of 441 nucleotides and M. genavense by 14 of 441 nucleotides of the hsp65 gene sequence.

Pathogenesis

M. montefiorense has been demonstrated to cause granulomatous skin disease of moray eels.
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