Mycobacterium cookii
Encyclopedia
Mycobacterium cookii

Description

Gram-positive
Gram-positive
Gram-positive bacteria are those that are stained dark blue or violet by Gram staining. This is in contrast to Gram-negative bacteria, which cannot retain the crystal violet stain, instead taking up the counterstain and appearing red or pink...

, nonmotile and polymorphic acid-fast rods (0.8 µm x 1.4–1.9 µm). Forms clumps, but not cords or cross bands. Does not form spores, capsules and aerial hyphae.

Colony characteristics
  • Colonies
    Colony (biology)
    In biology, a colony reference to several individual organisms of the same species living closely together, usually for mutual benefit, such as stronger defense or the ability to attack bigger prey. Some insects live only in colonies...

     are smooth and glistening with yellow-orange pigmentation (0.5–1.0 mm diameter, scotochromogenic).


Physiology
  • Slow growth on Löwenstein-Jensen medium or Middlebrook 7H10 agar at 31°C (optimal temperature). No growth at 37°C, 42°C or 45°C.
  • Most of the strains are susceptible to ethambutol
    Ethambutol
    Ethambutol is a bacteriostatic antimycobacterial drug prescribed to treat tuberculosis. It is usually given in combination with other tuberculosis drugs, such as isoniazid, rifampicin and pyrazinamide....

    , isoniazid
    Isoniazid
    Isoniazid , also known as isonicotinylhydrazine , is an organic compound that is the first-line antituberculosis medication in prevention and treatment. It was first discovered in 1912, and later in 1951 it was found to be effective against tuberculosis by inhibiting its mycolic acid...

    , streptomycin
    Streptomycin
    Streptomycin is an antibiotic drug, the first of a class of drugs called aminoglycosides to be discovered, and was the first antibiotic remedy for tuberculosis. It is derived from the actinobacterium Streptomyces griseus. Streptomycin is a bactericidal antibiotic. Streptomycin cannot be given...

    , and rifampin.


Differential characteristics
  • Phylogenetic position between the slowly growing pathogenic species and the saprotrophic rapidly growing species by partial 16S rDNA sequencing.

Pathogenesis

  • Not pathogenic for human
    Human
    Humans are the only living species in the Homo genus...

    s, mice
    MICE
    -Fiction:*Mice , alien species in The Hitchhiker's Guide to the Galaxy*The Mice -Acronyms:* "Meetings, Incentives, Conferencing, Exhibitions", facilities terminology for events...

    , guinea pig
    Guinea pig
    The guinea pig , also called the cavy, is a species of rodent belonging to the family Caviidae and the genus Cavia. Despite their common name, these animals are not in the pig family, nor are they from Guinea...

    s and rabbit
    Rabbit
    Rabbits are small mammals in the family Leporidae of the order Lagomorpha, found in several parts of the world...

    s. Biosafety level 1.
  • Provokes a non-specific hypersensitivity reaction to bovine tuberculin
    Tuberculin
    Tuberculin is the name given to extracts of Mycobacterium tuberculosis, M. bovis, or M. avium that is used in skin testing in animals and humans to identify a tuberculosis infection. Several types of tuberculin have been used for this, of which purified protein derivative is the most important....

    .

Type strain

Strain NZ2 = ATCC
American Type Culture Collection
The American Type Culture Collection is a private, not-for-profit biological resource center whose mission focuses on the acquisition, authentication, production, preservation, development and distribution of standard reference microorganisms, cell lines and other materials for research in the...

49103 = CIP 105396 = DSM 43922 = JCM 12404.
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