Mouse brain development timeline
Encyclopedia
Species
Species
In biology, a species is one of the basic units of biological classification and a taxonomic rank. A species is often defined as a group of organisms capable of interbreeding and producing fertile offspring. While in many cases this definition is adequate, more precise or differing measures are...

: Mus musculus
Family: Muridae
Muridae
Muridae is the largest family of mammals. It contains over 600 species found naturally throughout Eurasia, Africa, and Australia. They have been introduced worldwide. The group includes true mice and rats, gerbils, and relatives....


Order
Order (biology)
In scientific classification used in biology, the order is# a taxonomic rank used in the classification of organisms. Other well-known ranks are life, domain, kingdom, phylum, class, family, genus, and species, with order fitting in between class and family...

: Rodent
Rodent
Rodentia is an order of mammals also known as rodents, characterised by two continuously growing incisors in the upper and lower jaws which must be kept short by gnawing....

ia
Gestation
Gestation
Gestation is the carrying of an embryo or fetus inside a female viviparous animal. Mammals during pregnancy can have one or more gestations at the same time ....

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Day Event Reference
9 cranial motor nuclei - peak of neurogenesis
Neurogenesis
Neurogenesis is the process by which neurons are generated from neural stem and progenitor cells. Most active during pre-natal development, neurogenesis is responsible for populating the growing brain with neurons. Recently neurogenesis was shown to continue in several small parts of the brain of...

Finlay and Darlington (1995)
10 subplate
Subplate
The transient fetal subplate zone, together with the marginal zone and the cortical plate, represents the developmental anlage of the mammalian cerebral cortex...

 -start of neurogenesis
Bayer and Altman (1991)
10 inferior olivary nucleus - peak of neurogenesis Finlay and Darlington (1995)
10.5 retinal ganglion cell generation - start of neurogenesis Robinson and Dreher (1990)
10.5 superficial superior colliculus
Superior colliculus
The optic tectum or simply tectum is a paired structure that forms a major component of the vertebrate midbrain. In mammals this structure is more commonly called the superior colliculus , but, even in mammals, the adjective tectal is commonly used. The tectum is a layered structure, with a...

 (SC) laminae- start of neurogenesis
Robinson and Dreher (1990)
10.5 dorsal lateral geniculate nucleus
Lateral geniculate nucleus
The lateral geniculate nucleus is the primary relay center for visual information received from the retina of the eye. The LGN is found inside the thalamus of the brain....

 (dLGN) - start of neurogenesis
Robinson and Dreher (1990)
10.5 Purkinje cells - peak of neurogenesis Finlay and Darlington (1995)
11 cranial sensory nuclei
Cranial nerve nucleus
A cranial nerve nucleus is a collection of neurons in the brain stem that is associated with one or more cranial nerves. Axons carrying information to and from the cranial nerves form a synapse first at these nuclei. Lesions occurring at these nuclei can lead to effects resembling those seen by...

 - peak of neurogenesis
Finlay and Darlington (1995)
11 subplate - peak of neurogenesis Finlay and Darlington (1995)
11 reticular nuclei - peak of neurogenesis Finlay and Darlington (1995)
11 medial geniculate nucleus
Medial geniculate nucleus
The Medial Geniculate Nucleus or Medial Geniculate Body is part of the auditory thalamus and represents the thalamic relay between the inferior colliculus and the auditory cortex...

 - peak of neurogenesis
Finlay and Darlington (1995)
11 globus pallidus
Globus pallidus
The globus pallidus also known as paleostriatum, is a sub-cortical structure of the brain. Topographically, it is part of the telencephalon, but retains close functional ties with the subthalamus - both of which are part of the extrapyramidal motor system...

 - peak of neurogenesis
Finlay and Darlington (1995)
11.5 ventral LGN - peak of neurogenesis Finlay and Darlington (1995)
12 dLGN - peak of neurogenesis Finlay and Darlington (1995)
12 cochlear nuclei
Cochlear nuclei
The cochlear nuclei are two heterogeneous collections of neurons in the mammalian brainstem that receive input from the cochlear nerve, which carry sound information from the cochleae...

 - peak of neurogenesis
Finlay and Darlington (1995)
12 mitral cells - peak of neurogenesis Finlay and Darlington (1995)
12 amygdala
Amygdala
The ' are almond-shaped groups of nuclei located deep within the medial temporal lobes of the brain in complex vertebrates, including humans. Shown in research to perform a primary role in the processing and memory of emotional reactions, the amygdalae are considered part of the limbic system.-...

 - peak of neurogenesis
Finlay and Darlington (1995)
12 subplate - end of neurogenesis Bayer and Altman (1991)
12.3 axons in optic stalk
Optic stalk
The optic vesicles project toward the sides of the head, and the peripheral part of each expands to form a hollow bulb, while the proximal part remains narrow and constitutes the optic stalk....

 
Dunlop et al. (1997)
12.5 ventral posterior nucleus
Ventral posterior nucleus
The ventral posterior nucleus is the somato-sensory relay nucleus in thalamus of the brain.-Input and output:The ventral posterior nucleus receives neuronal input from the medial lemniscus, spinal lemniscus, spinothalamic tracts, and trigeminothalamic tract...

 (VP) and ventrobasal nucleus
Ventrobasal complex
-Function:The ventrobasal complex receives sensory input from the medial lemniscus , from spinothalamic tracts, and from the trigeminal nerve. It subsequently relays the inputs to the primary sensory area of the cerebral cortex. Synchronously, it distinguishes sensory inputs from deep sensory...

 (VB) of the thalamus
Thalamus
The thalamus is a midline paired symmetrical structure within the brains of vertebrates, including humans. It is situated between the cerebral cortex and midbrain, both in terms of location and neurological connections...

 - peak of neurogenesis
Finlay and Darlington (1995)
12.5 nucleus of lateral olfactory tract
Olfactory tract
The olfactory tract is a bundle of axons connecting the mitral and tufted cells of the olfactory bulb to several target regions in the brain, including piriform cortex, amygdala, and entorhinal cortex...

 - peak of neurogenesis
Finlay and Darlington (1995)
12.5 claustrum
Claustrum
The claustrum, which is suspected to be present in all mammals, is a fairly thin vertical curved sheet of subcortical gray matter...

 - peak of neurogenesis
Finlay and Darlington (1995)
12.5 neurogenesis cortical layer VI - peak (VC) of neurogenesis Finlay and Darlington (1995)
12.5 dLGN- end of neurogenesis Robinson and Dreher (1990)
12.5 preoptic nucleus
Preoptic nucleus
Preoptic nucleus can refer to:* Ventrolateral preoptic nucleus* Anterodorsal preoptic nucleus* Preoptic area...

 - peak of neurogenesis
Finlay and Darlington (1995)
13 medial forebrain bundle
Medial forebrain bundle
The Medial forebrain bundle , is a complex bundle of axons coming from the basal olfactory regions, the periamygdaloid region, and the septal nuclei.-Anatomy:...

 appears
Ashwell et al. (1996)
13 suprachiasmatic nucleus
Suprachiasmatic nucleus
The suprachiasmatic nucleus or nuclei, abbreviated SCN, is a tiny region on the brain's midline, situated directly above the optic chiasm. It is responsible for controlling circadian rhythms...

 - peak of neurogenesis
Finlay and Darlington (1995)
13 optic axons at chiasm of optic tract
Optic chiasm
The optic chiasm or optic chiasma is the part of the brain where the optic nerves partially cross...

 
Dunlop et al. (1997)
13 superior colliculus
Superior colliculus
The optic tectum or simply tectum is a paired structure that forms a major component of the vertebrate midbrain. In mammals this structure is more commonly called the superior colliculus , but, even in mammals, the adjective tectal is commonly used. The tectum is a layered structure, with a...

 - peak of neurogenesis
Finlay and Darlington (1995)
13 retinal ganglion cells - peak of neurogenesis Finlay and Darlington (1995)
13 septal nuclei
Septal nuclei
The septal area are structures that lie below the rostrum of corpus callosum in front of lamina terminalis , composed of medium-size neurons grouped into medial, lateral, and posterior groups...

 - peak of neurogenesis
Finlay and Darlington (1995)
13 entorhinal cortex
Entorhinal cortex
The entorhinal cortex is located in the medial temporal lobe and functions as a hub in a widespread network for memory and navigation. The EC is the main interface between the hippocampus and neocortex...

 - peak of neurogenesis
Finlay and Darlington (1995)
13 subiculum
Subiculum
The subiculum is the most inferior component of the hippocampal formation. It lies between the entorhinal cortex and the CA1 subfield of the hippocampus proper.-Paths:...

 – peak of neurogenesis
Finlay and Darlington (1995)
13 neurogenesis cortical layer V - peak (VC) of neurogenesis Finlay and Darlington (1995)
13 neurogenesis cortical lamina VI - end (VC) of neurogenesis Caviness (1982)
13.5 raphe complex - peak of neurogenesis Finlay and Darlington (1995)
13.5 anterior olfactory nucleus
Anterior olfactory nucleus
The anterior olfactory nucleus is a portion of the forebrain of vertebrates.It is involved in olfaction.-Location:...

 - peak of neurogenesis
Finlay and Darlington (1995)
13.5 anteroventral (AV), anterodorsal (AD) and anteromedial (AM) thalamic nuclei - peak of neurogenesis Finlay and Darlington (1995)
13.5 pontine nuclei
Pontine nuclei
The pontine nuclei are a part of the pons involved in motor activity. Corticopontine fibres carry information from the primary motor cortex to the ipsilateral pontine nucleus in the ventral pons, and the pontocerebellar projection then carries that information to the contralateral cerebellum via...

 – peak of neurogenesis
Finlay and Darlington (1995)
13.5 parasubiculum
Parasubiculum
In the rodent, the parasubiculum is a retrohippocampal isocortical structure, and a major component of the subicular complex. It receives numerous subcortical and cortical inputs, and sends major projections to the superficial layers of the entorhinal cortex .The parasubicular area is a...

 – peak of neurogenesis
Finlay and Darlington (1995)
13.5 stria terminalis appears Ashwell et al. (1996)
13.5 presubiculum – peak of neurogenesis Finlay and Darlington (1995)
14 fasciculus retroflexus appears Finlay and Darlington (1995)
14 caudoputamen – peak of neurogenesis Finlay and Darlington (1995)
14 superficial SC laminae - end of neurogenesis Robinson and Dreher (1990)
14 fornix appears Ashwell et al. (1996)
14 cones - peak of neurogenesis Finlay and Darlington (1995)
14 neurogenesis cortical layer V - end (VC) of neurogenesis Caviness (1982)
14.5 optic axons reach dLGN and SC Robinson and Dreher (1990)
14.5 anterior commisure appears Ashwell et al. (1996)
15 neurogenesis cortical lamina IV - start (VC) of neurogenesis Caviness (1982)
15 CA 1, CA 2 of hippocampus
Hippocampus
The hippocampus is a major component of the brains of humans and other vertebrates. It belongs to the limbic system and plays important roles in the consolidation of information from short-term memory to long-term memory and spatial navigation. Humans and other mammals have two hippocampi, one in...

 - peak of neurogenesis
Finlay and Darlington (1995)
15 retinal amacrine cells - peak of neurogenesis Finlay and Darlington (1995)
15 hippocampal commissure
Commissure of fornix
The lateral portions of the body of the fornix are joined by a thin triangular lamina, named the psalterium . This lamina contains some transverse fibers that connect the two hippocampi across the middle line and constitute the commissure of fornix .The terminal lamina creates the commisure plate...

 appears
Ashwell et al. (1996)
15 neurogenesis cortical layer II /III - peak (VC) of neurogenesis Finlay and Darlington (1995)
15.5 optic axons invade visual centers Dunlop et al. (1997)
16 nucleus accumbens
Nucleus accumbens
The nucleus accumbens , also known as the accumbens nucleus or as the nucleus accumbens septi , is a collection of neurons and forms the main part of the ventral striatum...

 - peak of neurogenesis
Finlay and Darlington (1995)
16 tufted cells - peak of neurogenesis Finlay and Darlington (1995)
16 isles of Calleja - peak of neurogenesis Finlay and Darlington (1995)
17 neurogenesis cortical layer IV - peak (VC) of neurogenesis Caviness (1982)
17 corpus callosum
Corpus callosum
The corpus callosum , also known as the colossal commissure, is a wide, flat bundle of neural fibers beneath the cortex in the eutherian brain at the longitudinal fissure. It connects the left and right cerebral hemispheres and facilitates interhemispheric communication...

 appears
Ashwell et al. (1996)
17 neurogenesis cortical layer IV - end (VC) of neurogenesis Bayer and Altman (1991)
18.5 retinal ganglion cell generation - end of neurogenesis Robinson and Dreher (1990)
19 initial differentiation of layer V (S1) Finlay and Darlington (1995)
19 rods - peak of neurogenesis Finlay and Darlington (1995)
21 complete separation of layer V (S1) Rice et al. (1985)
22 onset of barrels
Barrel cortex
The barrel cortex refers to the dark-staining regions of layer four of the somatosensory cortex where somatosensory inputs from the contralateral side of the body come in from the thalamus. Barrels are found in some species of rodents and species of at least two other orders. The rest of this...

 (S1)
Rice et al. (1985)
22 onset of sublayers in layer V (S1) Rice et al. (1985)
22 onset of trilaminar plate (S1) Rice et al. (1985)
24 onset of barrel field septa (S1) Rice et al. (1985)
25.5 ipsi/contra segregation in LGN and SC Robinson and Dreher (1990)
30 eye
Eye
Eyes are organs that detect light and convert it into electro-chemical impulses in neurons. The simplest photoreceptors in conscious vision connect light to movement...

 opening
Dunlop et al. (1997)

See also

  • Brain development timelines
    Brain development timelines
    These are timelines of brain development events in different species.*Mouse brain development timeline*Macaque brain development timeline*Human brain development timeline-External links:* ...

  • Neural development
    Neural development
    Neural development comprises the processes that generate, shape, and reshape the nervous system, from the earliest stages of embryogenesis to the final years of life. The study of neural development aims to describe the cellular basis of brain development and to address the underlying mechanisms...

  • http://www.translatingtime.net Translating Time: A website providing translation of brain developmental times among different species
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