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Minimum Information Standards

Minimum Information Standards

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Minimum Information standards or reporting guidelines specify the minimum amount of meta data (information) and data required to meet a specific aim or aims. Usually the aim is to provide enough meta data and data to enable the unambiguous reproduction and interpretation of an experiment. MI guidelines are normally informal human readable specifications that inform the development of formal data models (e.g. XML
XML
Extensible Markup Language is a set of rules for encoding documents in machine-readable form. It is defined in the XML 1.0 Specification produced by the W3C, and several other related specifications, all gratis open standards....

 or UML
Unified Modeling Language
Unified Modeling Language is a standardized general-purpose modeling language in the field of object-oriented software engineering. The standard is managed, and was created, by the Object Management Group...

), data exchange formats (e.g. FuGE, MAGE-ML, MAGE-TAB) or knowledge models such as an ontology
Ontology
Ontology is the philosophical study of the nature of being, existence or reality as such, as well as the basic categories of being and their relations...

 (e.g. OBI
Ontology for Biomedical Investigations
The Ontology for Biomedical Investigations is an open access, integrated ontology for the description of biological and clinical investigations. OBI provides a model for the design of an investigation, the protocols and instrumentation used, the materials used, the data generated and the type of...

, MGED-Ontology).

MI standards are developed by working bodies of practitioners working in a particular scientific domain. The MI standards listed below are all from the life sciences, largely driven by the development of high throughput experimental technologies.

These MI standards groups have been brought together in 2007 to form the "Minimum Information about a Biomedical or Biological Investigation" (MIBBI) umbrella community. More information about the MIBBI initiative and the MIBBI Foundry can be found below and on the MIBBI homepage

MIAME, gene expression microarray


Minimum Information About a Microarray Experiment (MIAME) describes the Minimum Information About a Microarray Experiment that is needed to enable the interpretation of the results of the experiment unambiguously and potentially to reproduce the experiment and is aimed at facilitating the dissemination of data from microarray experiments.

MIAME contains a number of extensions to cover specific biological domains

MINI: Electrophysiology


Electrophysiology
Electrophysiology
Electrophysiology is the study of the electrical properties of biological cells and tissues. It involves measurements of voltage change or electric current on a wide variety of scales from single ion channel proteins to whole organs like the heart...

 is a technology used to study the electrical properties of biological cells and tissues. Electrophysiology typically involves the measurements of voltage change or electrical current flow on a wide variety of scales from single ion channel
proteins to whole tissues. This document is a single module, as part of the Minimum Information about a Neuroscience investigation (MINI) family of reporting guideline
documents, produced by community consultation and continually available for public comment. A MINI module represents the minimum information that should be reported about a dataset to facilitate computational access and analysis to allow a reader to interpret and critically evaluate the processes performed and the conclusions reached, and to support their experimental corroboration. In practice a MINI module comprises a checklist of information that should be provided (for example about the protocols employed) when
a data set is described for publication. The full specification of the MINI module can be found here.

MIARE, RNAi experiment


Minimum Information About an RNAi Experiment (MIARE) is a data reporting guideline which describes the minimum information that should be reported about an RNAi experiment to enable the unambiguous interpretation and reproduction of the results.

MIACA, cell based assay


Advances in genomics and functional genomics have enabled large-scale analyses of gene and protein function by means of high-throughput cell biological analyses. Thereby, cells in culture can be perturbed in vitro and the induced effects recorded and analyzed. Perturbations can be triggered in several ways, for instance with molecules (siRNAs, expression constructs, small chemical compounds, ligands for receptors, etc.), through environmental stresses (such as temperature shift, serum starvation, oxygen deprivation, etc.), or combinations thereof. The cellular responses to such perturbations are analyzed in order to identify molecular events in the biological processes addressed and understand biological principles.
We propose the Minimum Information About a Cellular Assay (MIACA) for reporting a cellular assay, and CA-OM, the modular cellular assay object model, to facilitate exchange of data and accompanying information, and to compare and integrate data that originate from different, albeit complementary approaches, and to elucidate higher order principles. Documents describing MIACA are available and provide further information as well as the checklist of terms that should be reported.

MIAPE, proteomic experiments


The Minimum Information About a Proteomic Experiment documents describe information which should be given along with a proteomic experiment. The parent document describes the processes and principles underpinning the development of a series of domain specific documents which now cover all aspects of a MS-based proteomics workflow.

MIMIx, molecular interactions


This document has been developed and maintained by the Molecular Interaction worktrack of the HUPO-PSI (www.psidev.info) and describes the Minimum Information about a Molecular Interaction experiment.

MIAPAR, protein affinity reagents


The Minimum Information About a Protein Affinity Reagent has been developed and maintained by the Molecular Interaction worktrack of the HUPO-PSI (www.psidev.info)in conjunction with the HUPO Antibody Initiative and a European consortium of binder producers and seeks to encourage users to improve their description of binding reagents, such as antibodies, used in the process of protein identification.

MIABE, bioactive entities


The Minimum Information About a Bioactive Entity was produced by representatives from both large pharma and academia who are looking to improve the description of usually small molecules which bind to, and potentially modulate the activity of, specific targets in a living organism. This document encompasses drug-like molecules as well as hebicides, pesticides and food additives. It is primarily maintained through the EMBL-EBI Industry program (www.ebi.ac.uk/industry).

MIGS/MIMS, genome/metagenome sequences


This specification is being developed by the Genomic Standards Consortium
Genomic Standards Consortium
The Genomic Standards Consortium is an initiative working towards richer descriptions of our collection of genomes, metagenomes and marker genes. Established in September 2005, this international community includes representatives from a range of major sequencing and bioinformatics centres and...


Minimum Information about a Flow Cytometry Experiment


The fundamental tenet of any scientific research is that the published results of any study have to be open to independent validation or refutation. The Minimum Information about a Flow Cytometry Experiment (MIFlowCyt) establishes the criteria to record information about the experimental overview, samples, instrumentation and data analysis. It promotes consistent annotation of clinical, biological and technical issues surrounding a flow cytometry experiment by specifying the requirements for data content and by providing a structured framework for capturing information.

More information can be found at:
  • The Flow Informatics and Computational Cytometry Socienty (FICCS) MIFlowCyt wiki page.
  • The Bioinformatics Standards for Flow Cytometry MIFlowCyt web page.

MIRIAM, Minimum Information Required in the Annotation of Models


The Minimal Information Required In the Annotation of Models (MIRIAM
MIRIAM
MIRIAM , is an effort to standardize the annotation and curation process of quantitative models of biological systems...

), is a set of rules for the curation and annotation of quantitative models of biological systems.

MIASE, Minimum Information About a Simulation Experiment


The Minimum Information About a Simulation Experiment (MIASE) is an effort to standardize the description of simulation experiments in the field of systems biology.

MIBBI Minimum Information for Biological and Biomedical Investigations


A ‘one-stop shop’ for exploring the range of extant projects, foster collaborative development and ultimately promote gradual integration.

FGED Society


FGED Society is an international organisation of biologists, computer scientists, and data analysts that aims to facilitate the sharing of data generated by functional genomics
Functional genomics
Functional genomics is a field of molecular biology that attempts to make use of the vast wealth of data produced by genomic projects to describe gene functions and interactions...

 experiments using DNA microarray
DNA microarray
A DNA microarray is a collection of microscopic DNA spots attached to a solid surface. Scientists use DNA microarrays to measure the expression levels of large numbers of genes simultaneously or to genotype multiple regions of a genome...

and other genome-scale technologies.

HUPO-PSI HUPO Protein Standards Initiative


The HUPO Proteomics Standards Initiative (PSI) defines community standards for data representation in proteomics to facilitate data comparison, exchange and verification.

FuGE Functional Genomics Experiment


FuGE provides a model of common components in functional genomics investigations. It can be extended to develop modular data formats and provides a consistent framework to capture complete lab workflows.

MSI The Metabolomics Standards Initiative


MSI has be appointed by the Metabolomics Society to monitor, coordinate and review the efforts of working groups in specialist areas that will examine standardization and make recommendations.

MIACA, Minimum Information About a Cellular Assay


Minimum Information About a Cellular Assay (MIACA) is a data reporting guideline which describes the minimum information that should be reported about a Cellular Assay Experiment to enable the interpretation of results, and the exchange and integration of data and information.

MIARE, Minimum Information About an RNAi Experiment


Minimum Information About an RNAi Experiment (MIARE) is a data reporting guideline which describes the minimum information that should be reported about an RNAi experiment to enable the unambiguous interpretation and reproduction of the results.

MIFlowCyt, Minimum Information about a Flow Cytometry Experiment


Minimum Information about a Flow Cytometry Experiment (MIFlowCyt) is a data reporting guideline which describes the minimum information that should be reported about a flow cytometry experiment to enable the interpretation of the results.

Nature Community Consultation


Standards papers under consideration for publication in Nature Biotechnology.