Membrane introduction mass spectrometry
Encyclopedia
Membrane-introduction mass spectrometry (MIMS) is a method of introducing analytes into the mass spectrometer's vacuum chamber via a semipermeable
Semipermeable membrane
A semipermeable membrane, also termed a selectively permeable membrane, a partially permeable membrane or a differentially permeable membrane, is a membrane that will allow certain molecules or ions to pass through it by diffusion and occasionally specialized "facilitated diffusion".The rate of...

 membrane
Artificial membrane
An artificial membrane, or synthetic membrane, is a synthetically created membrane which is usually intended for separation purposes in laboratory or in industry. Synthetic membranes have been successfully used for small and large-scale industrial processes since the middle of twentieth century. A...

. Usually a thin, gas permeable, hydrophobic membrane is used, for example polydimethylsiloxane
Polydimethylsiloxane
Polydimethylsiloxane belongs to a group of polymeric organosilicon compounds that are commonly referred to as silicones. PDMS is the most widely used silicon-based organic polymer, and is particularly known for its unusual rheological properties. PDMS is optically clear, and, in general, is...

. Samples can be almost any fluid including water, air or sometimes even solvents. The great advantage of the method of sample introduction is its simplicity. MIMS can be used to measure a variety of analytes in real-time, with little or no sample preparation. MIMS is most useful for the measurement of small, non-polar molecules, since molecules of this type have a greater affinity for the membrane material than the sample.

See also

  • Atmospheric pressure chemical ionization
    Atmospheric pressure chemical ionization
    Atmospheric-pressure chemical ionization is an ionization method used in mass spectrometry. It is a form of chemical ionization which takes place at atmospheric pressure.-How it works:...

  • Liquid chromatography-mass spectrometry
    Liquid chromatography-mass spectrometry
    Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry. LC-MS is a powerful technique used for many applications which has very high...

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