Megalocornea
Encyclopedia
Megalocornea is an extremely rare nonprogressive condition in which the cornea
has an enlarged diameter
, reaching and exceeding 13 mm. It is noted in some patients with Marfan syndrome
. It is thought to have two subforms, one with autosomal inheritance and the other X-linked (Xq21.3-q22). The X-linked form is more commons and males generally constitute 90% of cases.
Cornea
The cornea is the transparent front part of the eye that covers the iris, pupil, and anterior chamber. Together with the lens, the cornea refracts light, with the cornea accounting for approximately two-thirds of the eye's total optical power. In humans, the refractive power of the cornea is...
has an enlarged diameter
Diameter
In geometry, a diameter of a circle is any straight line segment that passes through the center of the circle and whose endpoints are on the circle. The diameters are the longest chords of the circle...
, reaching and exceeding 13 mm. It is noted in some patients with Marfan syndrome
Marfan syndrome
Marfan syndrome is a genetic disorder of the connective tissue. People with Marfan's tend to be unusually tall, with long limbs and long, thin fingers....
. It is thought to have two subforms, one with autosomal inheritance and the other X-linked (Xq21.3-q22). The X-linked form is more commons and males generally constitute 90% of cases.
See also
- Megalocornea-mental retardation syndrome (Neuhauser syndrome; MMMM-syndrome; OMIM %249310)
External links
- Megalocornea - eMedicineEMedicineeMedicine is an online clinical medical knowledge base that was founded in 1996 by Scott Plantz and Richard Lavely, two medical doctors. The website is searchable by keyword and consists of approximately 6,800 articles, each of which is associated with one of 62 clinical subspecialty textbooks...
ophthalmology; May 15, 2009; Thomas A Oetting, MD,Mark A Hendrix, MD - An Infant With Enlarged Corneas - medscape