Lipoamide

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Lipoamide

Lipoamide is a trivial name

Trivial name

In chemistry and zoology, a trivial name is a non-systematic name or non-scientific name. That is, the name is not recognised according to the rules of any formal system of nomenclature....
for 6,8-dithiooctanoic amide. It is 6,8-dithiooctanoic acid

Lipoic acid

Lipoic acid is an organic compound, one enantiomer of which is an essential cofactor for many enzyme complexes. The molecule consists of a carboxylic acid and a cyclic Disulfide bond....
's functional form where the carboxyl group is attached to protein

Protein

Proteins are organic compounds made of amino acids arranged in a linear chain and joined together by peptide bonds between the carboxyl and amino groups of adjacent amino acid Residue ....
(or any other amine

Amine

Amines are organic compounds and functional groups that contain a base nitrogen atom with a lone pair. Amines are derivative s of ammonia, wherein one or more hydrogen atoms are replaced by organic substituents such as alkyl and aryl groups....
) by an amide

Amide

In chemistry, an amide is one of three kinds of compounds:* the organic chemistry functional group characterized by a carbonyl group linked to a nitrogen atom , or a compound that contains this functional group ; or...
linkage (containing -NH₂) to an amino group

Amino acid

In chemistry, an amino acid is a molecule containing both amine and carboxyl functional groups. These molecules are particularly important in biochemistry, where this term refers to alpha-amino acids with the general formula H2NCHRCOOH, where R is an organic substituent....
.

Lipoamide forms a thioester bond, oxidizing the disulfide bond, with acetaldehyde (pyruvate after it has been decarboxylated). It then transfer the acetaldehyde group to CoA which can then continue in the TCA cycle.