Lemon balm
Encyclopedia
Lemon balm not to be confused with bee balm, Monarda
Monarda
Monarda is a genus consisting of roughly 16 species of erect, herbaceous, annual or perennial plants in the family Lamiaceae. The genus is endemic to North America. Ranging in height from 1 to 3 feet , the plants have an equal spread, with slender and long-tapering leaves...

species, is a perennial
Perennial plant
A perennial plant or simply perennial is a plant that lives for more than two years. The term is often used to differentiate a plant from shorter lived annuals and biennials. The term is sometimes misused by commercial gardeners or horticulturalists to describe only herbaceous perennials...

 herb
Herb
Except in botanical usage, an herb is "any plant with leaves, seeds, or flowers used for flavoring, food, medicine, or perfume" or "a part of such a plant as used in cooking"...

 in the mint
Mentha
Mentha is a genus of flowering plants in the family Lamiaceae . The species are not clearly distinct and estimates of the number of species varies from 13 to 18. Hybridization between some of the species occurs naturally...

 family Lamiaceae
Lamiaceae
The mints, taxonomically known as Lamiaceae or Labiatae, are a family of flowering plants. They have traditionally been considered closely related to Verbenaceae, but in the 1990s, phylogenetic studies suggested that many genera classified in Verbenaceae belong instead in Lamiaceae...

, native to southern Europe
Europe
Europe is, by convention, one of the world's seven continents. Comprising the westernmost peninsula of Eurasia, Europe is generally 'divided' from Asia to its east by the watershed divides of the Ural and Caucasus Mountains, the Ural River, the Caspian and Black Seas, and the waterways connecting...

 and the Mediterranean region.

It grows to 70–150 cm tall. The leaves
Leaf
A leaf is an organ of a vascular plant, as defined in botanical terms, and in particular in plant morphology. Foliage is a mass noun that refers to leaves as a feature of plants....

 have a gentle lemon
Lemon
The lemon is both a small evergreen tree native to Asia, and the tree's ellipsoidal yellow fruit. The fruit is used for culinary and non-culinary purposes throughout the world – primarily for its juice, though the pulp and rind are also used, mainly in cooking and baking...

 scent, related to mint. During summer, small white flower
Flower
A flower, sometimes known as a bloom or blossom, is the reproductive structure found in flowering plants . The biological function of a flower is to effect reproduction, usually by providing a mechanism for the union of sperm with eggs...

s full of nectar appear. These attract bee
Bee
Bees are flying insects closely related to wasps and ants, and are known for their role in pollination and for producing honey and beeswax. Bees are a monophyletic lineage within the superfamily Apoidea, presently classified by the unranked taxon name Anthophila...

s, hence the genus name Melissa
Melissa
Melissa is a given name for a female child. The name comes from the Greek word μέλισσα , "honey bee" and from μέλι , "honey". Compare Hittite melit, "honey"....

(Greek
Greek language
Greek is an independent branch of the Indo-European family of languages. Native to the southern Balkans, it has the longest documented history of any Indo-European language, spanning 34 centuries of written records. Its writing system has been the Greek alphabet for the majority of its history;...

 for 'honey bee'). Its flavour comes from citronellal
Citronellal
Citronellal or rhodinal or 3,7-dimethyloct-6-en-1-al is a monoterpenoid, the main component in the mixture of terpenoid chemical compounds that give citronella oil its distinctive lemon scent....

 (24%), geranial (16%), linalyl acetate
Linalyl acetate
Linalyl acetate is a naturally occurring phytochemical found in many flowers and spice plants. It is one of the principal components of the essential oils of bergamot and lavender. Chemically, it is the acetate ester of linalool, and the two often occur in conjunction.Synthetic linalyl acetate is...

 (12%) and caryophyllene
Caryophyllene
Caryophyllene , or -β-caryophyllene, is a natural bicyclic sesquiterpene that is a constituent of many essential oils, especially clove oil, the oil from the stems and flowers of Syzygium aromaticum , the essential oil of hemp Cannabis sativa, rosemary Rosmarinus oficinalis, and hops...

 (12%).

Cultivation

This herb can be easy to cultivate in Plant Hardiness Zones
Hardiness zone
A hardiness zone is a geographically defined area in which a specific category of plant life is capable of growing, as defined by climatic conditions, including its ability to withstand the minimum temperatures of the zone...

 4 to 9 according to the United States Department of Agriculture
United States Department of Agriculture
The United States Department of Agriculture is the United States federal executive department responsible for developing and executing U.S. federal government policy on farming, agriculture, and food...

. In zone 4, it needs well-drained sandy soil and a winter mulch or adequate snowcover to survive. In zone 7, it can be harvested at least until the end of November. While it prefers full sun (as described on most plant tags), it is moderately shade-tolerant, much more so than most herbs. In dry climates, it grows best in partial shade. It can also be easily grown as an indoor potted herb.

In North America, Melissa officinalis has escaped cultivation and spread into the wild.

Lemon balm requires light and at least 20 degrees Celsius (70 degrees Fahrenheit) to germinate, so it is best to plant indoors or in spring and not to cover the seeds.

Lemon balm grows in clumps and spreads vegetatively as well as by seed. In mild temperate zones, the stems of the plant die off at the start of the winter, but shoot up again in spring. It can be easily grown from stem cuttings rooted in water, or from seeds. Under ideal conditions, it will seed itself prolifically and can become a nuisance in gardens.

Melissa officinalis may be the "honey-leaf" (μελισσόφυλλον) mentioned by Theophrastus
Theophrastus
Theophrastus , a Greek native of Eresos in Lesbos, was the successor to Aristotle in the Peripatetic school. He came to Athens at a young age, and initially studied in Plato's school. After Plato's death he attached himself to Aristotle. Aristotle bequeathed to Theophrastus his writings, and...

. It was in the herbal garden of John Gerard
John Gerard
John Gerard aka John Gerarde was an English herbalist notable for his herbal garden and botany writing. In 1597 he published a large and heavily illustrated "Herball, or Generall Historie of Plantes", which went on to be the most widely circulated botany book in English in the 17th century...

, 1596.
There are many cultivars of Melissa officinalis, such as:
  • M. officinalis 'Citronella'
  • M. officinalis 'Lemonella'
  • M. officinalis 'Quedlinburger'
  • M. officinalis 'Lime'
  • M. officinalis ‘Variegata’
  • M. officinalis ‘Aurea’

(M. officinalis ‘Quedlinburger Niederliegende’ is an Improved variety bred for high essential oil content.)

Culinary use

Lemon balm is often used as a flavouring in ice cream
Ice cream
Ice cream is a frozen dessert usually made from dairy products, such as milk and cream, and often combined with fruits or other ingredients and flavours. Most varieties contain sugar, although some are made with other sweeteners...

 and herbal teas
Tisane
A herbal tea, tisane, or ptisan is a herbal or plant infusion and usually not made from the leaves of the tea bush . Typically, herbal tea is simply the combination of boiling water and dried fruits, flowers or herbs. Herbal tea has been imbibed for nearly as long as written history extends...

, both hot and iced
Iced tea
Iced tea is a form of cold tea, often served in a glass with ice. It may or may not be sweetened. Iced tea is also a popular packaged drink. It can be mixed with flavored syrup, with common flavors including lemon, peach, raspberry, lime, passion fruit, and cherry...

, often in combination with other herb
Herb
Except in botanical usage, an herb is "any plant with leaves, seeds, or flowers used for flavoring, food, medicine, or perfume" or "a part of such a plant as used in cooking"...

s such as spearmint
Spearmint
Mentha spicata syn. M. cordifolia is a species of mint native to much of Europe and southwest Asia, though its exact natural range is uncertain due to extensive early cultivation. It grows in wet soils...

. It is also frequently paired with fruit dishes or candies
Candy
Candy, specifically sugar candy, is a confection made from a concentrated solution of sugar in water, to which flavorings and colorants are added...

. It can be used in fish dishes and is the key ingredient in lemon balm pesto.
It has been suggested that it might be a better, healthier preservative than beta hydroxy acid
Beta hydroxy acid
A beta hydroxy acid or β-hydroxy acid is an organic compound that contains a carboxylic acid functional group and hydroxy functional group separated by two carbon atoms...

 in sausages

Medicinal uses

The crushed leaves, when rubbed on the skin, are used as a repellant for mosquito
Mosquito
Mosquitoes are members of a family of nematocerid flies: the Culicidae . The word Mosquito is from the Spanish and Portuguese for little fly...

s.

Lemon balm is also used medicinally as a herbal tea, or in extract form. It is claimed to have antibacterial and antiviral
Antiviral drug
Antiviral drugs are a class of medication used specifically for treating viral infections. Like antibiotics for bacteria, specific antivirals are used for specific viruses...

 properties (it is effective against herpes simplex
Herpes simplex
Herpes simplex is a viral disease caused by both Herpes simplex virus type 1 and type 2 . Infection with the herpes virus is categorized into one of several distinct disorders based on the site of infection. Oral herpes, the visible symptoms of which are colloquially called cold sores or fever...

).

It is also used as an anxiolytic
Anxiolytic
An anxiolytic is a drug used for the treatment of anxiety, and its related psychological and physical symptoms...

, mild sedative
Sedative
A sedative or tranquilizer is a substance that induces sedation by reducing irritability or excitement....

 or calming agent. At least one study has found it to be effective at reducing stress, although the study's authors call for further research. Lemon balm extract was identified as a potent inhibitor of GABA transaminase
4-aminobutyrate aminotransferase
4-aminobutyrate aminotransferase is an enzyme which catalyzes the conversion of 4-aminobutanoic acid and 2-oxoglutarate into succinic semialdehyde and glutamate.-Inhibitors:* Aminooxyacetic acid* Gabaculine* Phenelzine...

, which explains anxiolytic effects. The major compound responsible for GABA transaminase inhibition activity in lemon balm is rosmarinic acid
Rosmarinic acid
Rosmarinic acid, C18H16O8, is a natural phenol antioxidant carboxylic acid found in many Lamiaceae herbs used commonly as culinary herbs such as lemon balm, rosemary, oregano, sage, thyme and peppermint. Chemically, rosmarinic acid is an ester of caffeic acid with 3,4-dihydroxyphenyl lactic acid...

.

Lemon balm and preparations thereof also have been shown to improve mood and mental performance. These effects are believed to involve muscarinic and nicotinic acetylcholine receptors. Positive results have been achieved in a small clinical trial involving Alzheimer patients with mild to moderate symptoms.

Its antibacterial properties have also been demonstrated scientifically, although they are markedly weaker than those from a number of other plants studied. The extract of lemon balm was also found to have exceptionally high antioxidant
Antioxidant
An antioxidant is a molecule capable of inhibiting the oxidation of other molecules. Oxidation is a chemical reaction that transfers electrons or hydrogen from a substance to an oxidizing agent. Oxidation reactions can produce free radicals. In turn, these radicals can start chain reactions. When...

 activity.

Lemon balm is mentioned in the scientific journal Endocrinology, where it is explained that Melissa officinalis exhibits antithyrotropic activity, inhibiting TSH
TSH
TSH may refer to:* Tanzanian shilling, the currency of Tanzania* Thyroid-stimulating hormone, a hormone synthesized and secreted by thyrotrope cells* Tshiuetin Rail Transportation, a Canadian railway between Labrador and Quebec...

 from attaching to TSH receptors, hence making it of possible use in the treatment of Graves' disease
Graves' disease
Graves' disease is an autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones...

 or hyperthyroidism
Hyperthyroidism
Hyperthyroidism is the term for overactive tissue within the thyroid gland causing an overproduction of thyroid hormones . Hyperthyroidism is thus a cause of thyrotoxicosis, the clinical condition of increased thyroid hormones in the blood. Hyperthyroidism and thyrotoxicosis are not synonymous...

.

Lemon balm essential oil
Essential oil
An essential oil is a concentrated hydrophobic liquid containing volatile aroma compounds from plants. Essential oils are also known as volatile oils, ethereal oils or aetherolea, or simply as the "oil of" the plant from which they were extracted, such as oil of clove...

 is very popular in aromatherapy
Aromatherapy
Aromatherapy is a form of alternative medicine that uses volatile plant materials, known as essential oils, and other aromatic compounds for the purpose of altering a person's mind, mood, cognitive function or health....

. The essential oil is commonly co-distilled with lemon oil, citronella
Citronella
Citronella is a word used for several things, including:* Citronella , a genus of trees and shrubs in the Cardiopteridaceae* Citronella oil, an insect-repelling essential oil derived from Cymbopogon...

 oil, or other oils.

Lemon balm is used in some variations of the Colgate Herbal toothpaste for its soothing and aromatic properties.

Lemon balm should be avoided by those on thyroid medication (such as thyroxine
Thyroxine
Thyroxine, or 3,5,3',5'-tetraiodothyronine , a form of thyroid hormones, is the major hormone secreted by the follicular cells of the thyroid gland.-Synthesis and regulation:...

), as it is believed the herb inhibits the absorption of this medicine.

Despite extensive traditional medicinal use, melissa oil was initially prohibited by the International Fragrance Association (IFRA)'s 43rd amendment, but this restriction appears to have been revisited and relaxed in the 44th amendment.

One traditional use of lemon balm tea was in extending age, although this effect has not been proven.
Ob-X, a mixture of three herbs, Morus alba, M. officinalis, and Artemisia capillaris, may help regulate obesity. Ob-X reduces body weight gain and visceral adipose tissue mass in genetically obese mice.

Recent research found a daily dose of the tea reduced oxidative stress
Oxidative stress
Oxidative stress represents an imbalance between the production and manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage...

 status in radiology staff that were exposed to persistent
low-dose radiation during work. After only 30 days of taking the tea daily researchers found Lemon balm tea resulted in a significant improvement in plasma levels of catalase, superoxide dismutase
Superoxide dismutase
Superoxide dismutases are a class of enzymes that catalyze the dismutation of superoxide into oxygen and hydrogen peroxide. As such, they are an important antioxidant defense in nearly all cells exposed to oxygen...

, and glutathione peroxidase
Glutathione peroxidase
Glutathione peroxidase is the general name of an enzyme family with peroxidase activity whose main biological role is to protect the organism from oxidative damage...

 and a marked reduction in plasma
DNA damage, myeloperoxidase
Myeloperoxidase
Myeloperoxidase is a peroxidase enzyme that in humans is encoded by the MPO gene. Myeloperoxidase is most abundantly expressed in neutrophil granulocytes . It is a lysosomal protein stored in azurophilic granules of the neutrophil...

, and lipid peroxidation
Lipid peroxidation
Lipid peroxidation refers to the oxidative degradation of lipids. It is the process in which free radicals "steal" electrons from the lipids in cell membranes, resulting in cell damage. This process proceeds by a free radical chain reaction mechanism...

.

Chemistry

Lemon balm contains eugenol
Eugenol
Eugenol is a phenylpropene, an allyl chain-substituted guaiacol. Eugenol is a member of the phenylpropanoids class of chemical compounds. It is a clear to pale yellow oily liquid extracted from certain essential oils especially from clove oil, nutmeg, cinnamon, basil and bay leaf. It is slightly...

, which kills bacteria and has been shown to calm muscles and numb tissues. It also contains tannins that contribute to its antiviral effects, as well as terpene
Terpene
Terpenes are a large and diverse class of organic compounds, produced by a variety of plants, particularly conifers, though also by some insects such as termites or swallowtail butterflies, which emit terpenes from their osmeterium. They are often strong smelling and thus may have had a protective...

s that add to its soothing effects.

Melissa officinalis also contains 1-octen-3-ol
1-Octen-3-ol
1-Octen-3-ol, octenol for short , is a chemical that attracts biting insects such as mosquitos. It is contained in human breath and sweat, and it was once believed that insect repellent DEET works by blocking the insects' octenol odorant receptors.Octenol is used in combination with carbon dioxide...

, 10-alpha-cadinol, 3-octanol, 3-octanone, alpha-cubebene, alpha-humulene, beta-bourbonene, caffeic acid
Caffeic acid
Caffeic acid is a hydroxycinnamic acid, a naturally occurring organic compound. This yellow solid consists of both phenolic and acrylic functional groups...

, caryophyllene
Caryophyllene
Caryophyllene , or -β-caryophyllene, is a natural bicyclic sesquiterpene that is a constituent of many essential oils, especially clove oil, the oil from the stems and flowers of Syzygium aromaticum , the essential oil of hemp Cannabis sativa, rosemary Rosmarinus oficinalis, and hops...

, caryophyllene oxide, catechinene, chlorogenic acid
Chlorogenic acid
Chlorogenic acid is a hydroxycinnamic acid, a member of a family of naturally occurring organic compounds. These are esters of polyphenolic caffeic acid and cyclitol -quinic acid. It is an important biosynthetic intermediate. It also is one of the phenols found in coffee, bamboo Phyllostachys...

, cis-3-hexenol, cis-ocimene, citral A, citral B, citronellal
Citronellal
Citronellal or rhodinal or 3,7-dimethyloct-6-en-1-al is a monoterpenoid, the main component in the mixture of terpenoid chemical compounds that give citronella oil its distinctive lemon scent....

, copaene
Copaene
Copaene, or more precisely, α-copaene, is the common chemical name of an oily liquid hydrocarbon that is found in a number of essential oil-producing plants. The name is derived from that of the resin-producing tropical copaiba tree, Copaifera langsdorfii, from which the compound was first...

, delta-cadinene, eugenyl acetate, gamma-cadinene, geranial, geraniol
Geraniol
Geraniol is a monoterpenoid and an alcohol. It is the primary part of rose oil, palmarosa oil, and citronella oil . It also occurs in small quantities in geranium, lemon, and many other essential oils. It appears as a clear to pale-yellow oil that is insoluble in water, but soluble in most common...

, geranyl acetate, germacrene D, isogeranial, linalool, luteolin-7-glucoside, methylheptenone, neral
Neral
Neral may refer to:* An isomer of Citral* Neral, Raigad – A railway junction in Maharashtra en route to Matheran* A Romulan from Star Trek...

, nerol
Nerol
Nerol is a monoterpene found in many essential oils such as lemongrass and hops. It was originally isolated from neroli oil, hence its name. This colourless liquid is used in perfumery. Like geraniol, nerol has a sweet rose odor but it is considered to be fresher.Isomeric with nerol is geraniol,...

, octyl benzoate, oleanolic acid
Oleanolic acid
Oleanolic acid or oleanic acid is a naturally occurring triterpenoid, widely distributed in food and medicinal plants, related to betulinic acid. It can be found in Phytolacca americana , and Syzygium spp, garlic, etc...

, pomolic acid, protocatechuic acid
Protocatechuic acid
Protocatechuic acid is a dihydroxybenzoic acid, a type of phenolic acid. It has mixed effects on normal and cancer cells in in vitro and in vivo studies.-Biological effects:...

, rhamnazine, rosmarinic acid
Rosmarinic acid
Rosmarinic acid, C18H16O8, is a natural phenol antioxidant carboxylic acid found in many Lamiaceae herbs used commonly as culinary herbs such as lemon balm, rosemary, oregano, sage, thyme and peppermint. Chemically, rosmarinic acid is an ester of caffeic acid with 3,4-dihydroxyphenyl lactic acid...

, rosmarinin acid, stachyose
Stachyose
Stachyose is a tetrasaccharide consisting of two α--galactose units, one α--glucose unit, and one β--fructose unit sequentially linked as galgalglcfru. Stachyose is naturally found in numerous vegetables and plants.Stachyose is less sweet than sucrose, at about 28% on a weight basis...

, succinic acid
Succinic acid
Succinic acid is a dicarboxylic acid. Succinate plays a biochemical role in the citric acid cycle. The name derives from Latin succinum, meaning amber, from which the acid may be obtained....

, thymol
Thymol
Thymol is a natural monoterpene phenol derivative of cymene, C10H14O, isomeric with carvacrol, found in oil of thyme, and extracted from Thymus vulgaris and various other kinds of plants as a white crystalline substance of a pleasant aromatic odor and strong antiseptic properties...

, trans-ocimene and ursolic acid
Ursolic acid
Ursolic acid is a pentacyclic triterpene acid, used in cosmetics, that is also capable of inhibiting various types of cancer cells by inhibiting the STAT3 activation pathway and human fibrosarcoma cells by reducing the expression of matrix metalloproteinase-9 by acting through the glucocorticoid...

.

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