Isocarboxazid (
Marplan) is a
hydrazineHydrazine is an inorganic chemical compound with the formula N2H4. It is a colourless liquid with an ammonia-like odor and is derived from the same industrial chemistry processes that manufacture ammonia...
drugA drug, broadly speaking, is any substance that, when absorbed into the body of a living organism, alters normal bodily function. There is no single, precise definition, as there are different meanings in drug control law, government regulations, medicine, and colloquial usage.In pharmacology, a...
that is used as an
antidepressantAn antidepressant is a psychiatric medication used to alleviate mood disorders, such as major depression and dysthymia. Drugs including the monoamine oxidase inhibitors , tricyclic antidepressants , tetracyclic antidepressants , selective serotonin reuptake inhibitors , and serotonin-norepinephrine...
. It is an irreversible and nonselective
monoamine oxidase inhibitorMonoamine oxidase inhibitors are a class of powerful antidepressant drugs prescribed for the treatment of depression. They are particularly effective in treating atypical depression, and have also shown efficacy in smoking cessation....
(MAOI).
In the United States, isocarboxazid is approved for the treatment of depression, anxiety (panic disorder) with or without
agoraphobiaAgoraphobia is an anxiety disorder, often precipitated by the fear of having a panic attack in a setting from which there is no easy means of escape. As a result, sufferers of agoraphobia avoid public and/or unfamiliar places, especially large, open, spaces such as shopping malls or airports...
.
In the United Kingdom, isocarboxazid is licensed for the treatment of depression unresponsive to selective serotonin reuptake inhibitors (SSRIs).
A
randomized controlled trialA randomized controlled trial is a type of scientific experiment most commonly used in testing the efficacy or effectiveness of healthcare services or health technologies . RCTs are also employed in other research areas, such as judicial, educational, and social research...
published in December 1988 found that isocarboxazid significantly reduced
bingeA binge is any behavior indulged to excess. It can refer to:*Binge drinking, drinking large amounts of alcohol over a short period of time*Drug binge, ingesting large amounts of drugs over a short period of time...
ing and purging in
bulimia nervosaBulimia nervosa is an eating disorder characterized by recurrent binge eating, followed by compensatory behaviors. The most common form is defensive vomiting, sometimes called purging; fasting, the use of laxatives, enemas, diuretics, and over exercising are also common.The word bulimia derives...
, regardless of the presence or absence of depression or
personality disorderPersonality disorders, formerly referred to as character disorders, are a class of personality types which deviate from the contemporary expectations of a society....
.
Marplan by
Hoffmann-La RocheF. Hoffmann–La Roche Ltd. is a Swiss global health-care company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has shares listed on the SIX Swiss Exchange ....
, starting in 1959 and discontinuing in 1994.
Isocarboxazid (
Marplan) is a
hydrazineHydrazine is an inorganic chemical compound with the formula N2H4. It is a colourless liquid with an ammonia-like odor and is derived from the same industrial chemistry processes that manufacture ammonia...
drugA drug, broadly speaking, is any substance that, when absorbed into the body of a living organism, alters normal bodily function. There is no single, precise definition, as there are different meanings in drug control law, government regulations, medicine, and colloquial usage.In pharmacology, a...
that is used as an
antidepressantAn antidepressant is a psychiatric medication used to alleviate mood disorders, such as major depression and dysthymia. Drugs including the monoamine oxidase inhibitors , tricyclic antidepressants , tetracyclic antidepressants , selective serotonin reuptake inhibitors , and serotonin-norepinephrine...
. It is an irreversible and nonselective
monoamine oxidase inhibitorMonoamine oxidase inhibitors are a class of powerful antidepressant drugs prescribed for the treatment of depression. They are particularly effective in treating atypical depression, and have also shown efficacy in smoking cessation....
(MAOI).
Approved
In the United States, isocarboxazid is approved for the treatment of depression, anxiety (panic disorder) with or without
agoraphobiaAgoraphobia is an anxiety disorder, often precipitated by the fear of having a panic attack in a setting from which there is no easy means of escape. As a result, sufferers of agoraphobia avoid public and/or unfamiliar places, especially large, open, spaces such as shopping malls or airports...
.
In the United Kingdom, isocarboxazid is licensed for the treatment of depression unresponsive to selective serotonin reuptake inhibitors (SSRIs).
Others
A
randomized controlled trialA randomized controlled trial is a type of scientific experiment most commonly used in testing the efficacy or effectiveness of healthcare services or health technologies . RCTs are also employed in other research areas, such as judicial, educational, and social research...
published in December 1988 found that isocarboxazid significantly reduced
bingeA binge is any behavior indulged to excess. It can refer to:*Binge drinking, drinking large amounts of alcohol over a short period of time*Drug binge, ingesting large amounts of drugs over a short period of time...
ing and purging in
bulimia nervosaBulimia nervosa is an eating disorder characterized by recurrent binge eating, followed by compensatory behaviors. The most common form is defensive vomiting, sometimes called purging; fasting, the use of laxatives, enemas, diuretics, and over exercising are also common.The word bulimia derives...
, regardless of the presence or absence of depression or
personality disorderPersonality disorders, formerly referred to as character disorders, are a class of personality types which deviate from the contemporary expectations of a society....
.
United States
Marplan by
Hoffmann-La RocheF. Hoffmann–La Roche Ltd. is a Swiss global health-care company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has shares listed on the SIX Swiss Exchange ....
, starting in 1959 and discontinuing in 1994. After much patient and physician outcry, they resumed manufacturing just enough
Marplan to distribute on an as-needed basis. In October 1998, Hoffmann-La Roche and Oxford Pharmaceutical Services Inc. announced that Oxford, "is acquiring ownership of the
NDANDA is an abbreviation that may refer to:* National Dance Association, the oldest American organization for dance education* Non-disclosure agreement, a legal term* Next-Day Air, a specification for shipping...
for the
antidepressantAn antidepressant is a psychiatric medication used to alleviate mood disorders, such as major depression and dysthymia. Drugs including the monoamine oxidase inhibitors , tricyclic antidepressants , tetracyclic antidepressants , selective serotonin reuptake inhibitors , and serotonin-norepinephrine...
product Marplan (isocarboxazid) from Roche."
The maximum daily dose of isocarboxazid is 60 mg.
United Kingdom
Isocarboxazid is availably generically in the United Kingdom in the form of 10 mg tablets. However, it is considered 'less suitable for prescribing' by the British National Formulary (BNF).
See also
- Iproclozide
Iproclozide is a hydrazine drug that was previously used as an antidepressant. It is an irreversible and nonselective monoamine oxidase inhibitor . Dosage ranges from 10 mg to 30 mg per day. It is rapidly metabolized and has a very short half-life...
(Sursum)
- Iproniazid
Iproniazid is a hydrazine drug that was previously used as an antidepressant. It is an irreversible and nonselective monoamine oxidase inhibitor . It has been widely discontinued.-History:Iproniazid was the first antidepressant ever marketed...
(Marsilid)
- Mebanazine
Mebanazine is a hydrazine derivative and monoamine oxidase inhibitor .- See also :* Iproclozide * Iproniazid * Isocarboxazid * Nialamide * Phenelzine * Pheniprazine...
(Actomol)
- Nialamide
Nialamide was one of the first MAOI antidepressants...
(Niamid)
- Phenelzine
Phenelzine is a psychoactive drug of the hydrazine chemical class which is used as an antidepressant and anxiolytic or antipanic agent. It acts as a nonselective and irreversible monoamine oxidase inhibitor...
(Nardil)
- Pheniprazine
Pheniprazine is a hydrazine drug that was previously used as an antidepressant. It was also used in the treatment of angina pectoris and schizophrenia. Pheniprazine is an irreversible and nonselective monoamine oxidase inhibitor...
(Catron)
- Phenoxypropazine
Phenoxypropazine is a hydrazine derivative and monoamine oxidase inhibitor .-See also:* Iproclozide * Iproniazid * Isocarboxazid * Mebanazine * Nialamide * Phenelzine...
(Drazine)
- Pivalylbenzhydrazine
Pivalylbenzhydrazine is a hydrazine derivative and monoamine oxidase inhibitor .- See also :* Iproclozide * Iproniazid * Isocarboxazid * Mebanazine * Nialamide...
(Tersavid)
- Safrazine
Safrazine is a hydrazine derivative and monoamine oxidase inhibitor .- See also :* Iproclozide * Iproniazid * Isocarboxazid * Mebanazine * Nialamide * Phenelzine...
(Safra)