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Intubation

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Intubation



 
 
In medicine
Medicine

Medicine is the art and science of healing. It encompasses a range of health care practices evolved to maintain and restore health by the prevention and treatment of illness....
, intubation refers to the placement of a tube into an external or internal orifice of the body. Although the term can refer to endoscopic
Endoscopy

Endoscopy means looking inside and typically refers to looking inside the body for medical reasons using an instrument called an endoscope....
 procedures, it is most often used to denote tracheal intubation. Tracheal intubation is the placement of a flexible plastic tube into the trachea
Vertebrate trachea

The traceartes, or windpipe, is a tube that has an inner diameter of about 20-25 mm and a length of about 10-16 cm in humans. It commences at the larynx and bifurcates into the primary bronchus in mammals, and from the pharynx to the syrinx in birds, allowing the passage of air to the lungs....
 to protect the patient's airway and provide a means of mechanical ventilation.






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Intubation
In medicine
Medicine

Medicine is the art and science of healing. It encompasses a range of health care practices evolved to maintain and restore health by the prevention and treatment of illness....
, intubation refers to the placement of a tube into an external or internal orifice of the body. Although the term can refer to endoscopic
Endoscopy

Endoscopy means looking inside and typically refers to looking inside the body for medical reasons using an instrument called an endoscope....
 procedures, it is most often used to denote tracheal intubation. Tracheal intubation is the placement of a flexible plastic tube into the trachea
Vertebrate trachea

The traceartes, or windpipe, is a tube that has an inner diameter of about 20-25 mm and a length of about 10-16 cm in humans. It commences at the larynx and bifurcates into the primary bronchus in mammals, and from the pharynx to the syrinx in birds, allowing the passage of air to the lungs....
 to protect the patient's airway and provide a means of mechanical ventilation. The most common tracheal intubation is orotracheal intubation where, with the assistance of a laryngoscope
Laryngoscope

A laryngoscope is a medical instrument that is used to obtain a view of the vocal folds and the glottis, which is the space between the cords....
, an endotracheal tube
Endotracheal tube

An endotracheal tube is used in general anaesthesia, intensive care and emergency medicine for airway management and mechanical ventilation. The tube is inserted into a patient's vertebrate trachea in order to ensure that the airway is not closed off and that air is able to reach the lungs....
 is passed through the mouth, larynx
Larynx

The larynx , colloquially known as the voicebox, is an organ in the neck of mammals involved in protection of the vertebrate trachea and sound production....
, and vocal cords, into the trachea. A bulb is then inflated near the distal tip of the tube to help secure it in place and protect the airway from blood, vomit, and secretions. Another possibility is nasotracheal intubation where a tube is passed through the nose
Nose

Anatomically, a nose is a protuberance in vertebrates that houses the nostrils, or nares, which admit and expel air for Respiration in conjunction with the mouth....
, larynx
Larynx

The larynx , colloquially known as the voicebox, is an organ in the neck of mammals involved in protection of the vertebrate trachea and sound production....
, vocal cords
Vocal folds

The vocal folds, also known commonly as vocal cords, are composed of twin infoldings of mucous membrane stretched horizontally across the larynx....
, and trachea
Vertebrate trachea

The traceartes, or windpipe, is a tube that has an inner diameter of about 20-25 mm and a length of about 10-16 cm in humans. It commences at the larynx and bifurcates into the primary bronchus in mammals, and from the pharynx to the syrinx in birds, allowing the passage of air to the lungs....
.

Extubation is the removal of the tube.

Risk vs. benefit

Tracheal intubation is a potentially very dangerous invasive procedure that requires a great deal of clinical experience to master. When performed improperly (e.g., unrecognized esophageal intubation), the associated complications may rapidly lead to the patient's death. Consequently, tracheal intubation's role as the "gold standard" of advanced airway maintenance was downplayed (in favor of more basic techniques like bag-valve-mask ventilation) by the American Heart Association's Guidelines for Cardiopulminary Resuscitation in 2000, and again in 2005.

Despite this, Endotracheal Intubation is still the Gold Standard in airway care and provides the highest level of protection when moving a casualty, against vomitus and regurgitation, and from upper airway and maxilofacial haemorrhage.

Risk management

No single method for confirming tube placement has been shown to be 100% reliable. Accordingly, the use of multiple methods to confirm correct tube placement is now the standard of care
Standard of care

In tort law, the standard of care is the degree of prudence and caution required of an individual who is under a duty of care. A breach of the standard is necessary for a successful action in negligence....
. At least one of the methods utilized should be an instrument. Waveform capnography
Capnography

Capnography is the monitoring of the concentration or partial pressure of carbon dioxide in the respiratory gases. Its main development has been as a monitoring tool for use during anaesthesia and intensive care....
 is emerging as the gold standard
Gold standard (test)

In medicine, gold standard test refers to a diagnostic test or benchmark that is regarded as definitive.This can refer to diagnosing a disease process, or the criteria by which scientific evidence is evaluated....
 instrument for the confirmation of correct tube placement and maintenance of the tube once it is in place.

Predicting ease of intubation

  • Look externally (history of craniofacial traumas/previous surgery)
  • Evaluate 3,3,2 - three of the patient's fingers should be able to fit into his/her mouth when open, three fingers should comfortably fit between the chin and the throat, and two fingers in the thyromental distance (distance from thyroid cartilage to chin)
  • Mallampati score
    Mallampati score

    In anesthesiology, the Mallampati score, also Mallampati classification, is used to predict the ease of intubation. It is determined by looking at the anatomy of the oral cavity; specifically, it is based on the visibility of the base of uvula, faucial pillars and soft palate....
  • Obstructions (stridorous breath sounds, wheezing, etc)
  • Neck mobility (can patient tilt head back and then forward to touch chest)
  • Cormack-Lehane grading system (according to the percentage of glottic opening on laryngoscopy)


Observational methods to confirm correct tube placement

  • Direct visualization of the tube passing through the vocal cords
  • Clear and equal bilateral breath sounds
    Breath sounds

    Respiratory sounds refer to the specific sounds identified through auscultation of the respiratory system with a stethoscope.In this context, "adventitious" refers to sounds heard apart from the normal sounds of Inhalation and expiration....
     on auscultation of the chest
  • Absent sounds on auscultation of the epigastrium
    Epigastrium

    The epigastrium is the upper central region of the abdomen. It is located between the costal margins and the subcostal plane.The epigastrium is one of the nine anatomical regions of the abdomen, along with the right and left hypochondrium, right and left lateral regions , right and left inguinal regions , and the umbilical and pubic region...
  • Equal bilateral chest rise with ventilation
    Mechanical ventilation

    In medicine, mechanical ventilation is a method to mechanically assist or replace spontaneous respiration .Mechanical ventilation is typically used after an invasive intubation, a procedure wherein an endotracheal tube or tracheostomy tube is inserted into the airway....
  • Fogging of the tube
  • An absence of stomach contents in the tube


Instruments to confirm correct tube placement

  • Colorimetric end tidal CO2 detector
  • Waveform capnography
    Capnography

    Capnography is the monitoring of the concentration or partial pressure of carbon dioxide in the respiratory gases. Its main development has been as a monitoring tool for use during anaesthesia and intensive care....
  • Self inflating esophageal bulb
  • Pulse oximetry
    Pulse oximetry

    Pulse oximetry is a non-invasive method allowing the monitoring of the oxygenation of a patient's hemoglobin.A sensor is placed on a thin part of the patient's anatomy, usually a fingertip or earlobe, or in the case of a infant, across a foot, and a light containing both red and infrared wavelengths is passed from one side to the other....
     (patients with a pulse) - delay in fall of saturation, especially if pre-oxygenated
  • Oesophageal Detection Device (ODD) -


Tube maintenance

The tube is secured in place with tape or an endotracheal tube holder. A cervical collar is sometimes used to prevent motion of the airway. Tube placement should be confirmed after each physical move of the patient and after any unexplained change in the patient's clinical status. Continuous pulse oximetry and continuous waveform capnography are often used to monitor the tube's correct placement.

Indications

Tracheal intubation is performed by practitioners in various medical conditions:
  • Coma
    Coma

    In medicine, a coma is a profound state of unconsciousness. A comatose person cannot be awakened, fails to respond normally to pain or light, does not have sleep-wake cycles, and does not take voluntary actions....
    tose or intoxicated patients who are unable to protect their airways. In such patients, the throat muscles may lose their tone so that the upper airways obstruct or collapse and air can not easily enter into the lungs. Furthermore, protective airway reflexes such as coughing and swallowing, which serve to protect the airways against aspiration
    Pulmonary aspiration

    In medicine, aspiration is the entry of secretions or foreign material into the Vertebrate trachea and lungs.The patient may either inhalation the material, or it may be blown into the lungs during positive pressure ventilation or CPR....
     of secretions and foreign bodies, may be absent. With tracheal intubation, airway patency is restored and the lower airways can be protected from aspiration.
  • General anesthesia. In anesthetized patients spontaneous respiration may be decreased or absent due to the effect of anesthetics, opioid
    Opioid

    An opioid is a chemical substance that has a morphine-like action in the body. The main use is for analgesia. These agents work by binding to opioid receptors, which are found principally in the central nervous system and the gastrointestinal tract....
    s, or muscle relaxant
    Muscle relaxant

    A muscle relaxant is a drug which affects skeletal muscle function and decreases the muscle tone. It may be used to alleviate symptoms such as muscle spasms, pain, and hyperreflexia....
    s. To enable mechanical ventilation, an endotracheal tube is often used, although there are alternative devices such as face masks or laryngeal mask airway
    Laryngeal mask airway

    The laryngeal mask airway was invented in 1983 by Britishanaesthetist, Dr. Archie Brain....
    s.
  • Diagnostic manipulations of the airways such as bronchoscopy
    Bronchoscopy

    Bronchoscopy is a medical procedure of visualizing the inside of the airways for diagnostic and therapeutic purposes. An instrument is inserted into the airways, usually through the nose or mouth, or occasionally through a tracheostomy....
    .
  • Endoscopic operative procedures to the airways such as laser
    Laser

    A laser is a device that emits light through a process called stimulated emission. The term laser is an acronym for light amplification by stimulated emission of radiation....
     therapy or stent
    Stent

    In medicine, a stent is a man-made 'tube' inserted into a natural passage/conduit in the body to prevent, or counteract, a disease-induced, localized flow constriction....
    ing of the bronchi.
  • Patients who require respiratory support, including cardiopulmonary resuscitation
    Cardiopulmonary resuscitation

    Cardiopulmonary resuscitation is an emergency medical procedure for a victim of cardiac arrest or, in some circumstances, respiratory arrest. CPR is performed in hospitals, or in the community by layman or by emergency response professionals....
    .


Types of tubes


There are various types of tracheal tubes for oral or nasal intubation. Tubes may be flexible or preformed and relatively stiff. They are usually made of flexible plastic or silicone, though they may be armored with metallic rings to prevent kinking. Adult tubes have an inflatable cuff to seal the lower airways against air leakage and gross aspiration. The cuff must be maintained diligently in order to avoid complications from over-inflation, which can include rupture of the trachea, tracheal malacia, tracheoesophageal fistula
Fistula

In medicine, a fistula is an abnormal connection or passageway between two epithelium-lined organs or vessels that normally do not connect....
. Many of the complications of over-inflated cuffs can be traced to cuff pressure against the tracheal wall causing ischemia of the mucosa underneath.

Special double-lumen endotracheal tubes have been developed for ventilating each lung independently -- this is useful during lung and other intra-thoracic surgery. Smaller pediatric tubes generally are uncuffed, as the cricoid cartilage, the narrowest portion of the pediatric airway, often provides an adequate seal for mechanical ventilation. An excessive leak can sometimes be corrected through the placement of a larger (0.5 mm larger in internal diameter) endotracheal tube, although in difficult-to-ventilate patients even children may need to use cuffed tubes to allow for high pressure ventilation if the leak is too great to overcome with the ventilator.


Techniques

Chapter5figure69b Nasotracheal Intubation
Several techniques exist. Tracheal intubation can be performed by direct laryngoscopy (conventional technique), in which a laryngoscope
Laryngoscope

A laryngoscope is a medical instrument that is used to obtain a view of the vocal folds and the glottis, which is the space between the cords....
 is used to obtain a view of the glottis
Glottis

The glottis defined as the combination of the vocal folds and the space in between the folds ....
. A tube is then inserted under direct vision. This technique can usually only be employed if the patient is comatose (unconscious), under general anesthesia, or has received local or topical anesthesia to the upper airway structures (e.g., using a local anesthetic drug such as lidocaine).

Rapid Sequence Induction
Rapid sequence induction

Rapid Sequence Induction is an advanced medical procedure, designed for the expeditious intubation of the trachea of a patient. RSI is generally used for patients who have an increased risk of aspirating stomach contents into the lungs due to a current disease process....


The technique, RSI, strictly refers to the sedation and paralysis prior to an intubation procedure. The technique is a quicker form of the process normally used to "induce" a state of general anesthesia. The difference between an RSI and standard anaesthetic intubation is that the anaesthetist does not wait to see the effect of the drugs. Medications are utilized to allow rapid placement of an endotracheal tube between the vocal cords, while the cords are being visualized with the help of a laryngoscope. The neuromuscular blocking agents paralyse all of the patient's smooth muscles, most notably in the oropharynx, larynx, and diaphragm. Once the endotracheal tube has been passed between the vocal cords, a cuff is inflated around the tube in the trachea and the patient can then be artificially ventilated.

RSI involves pre-oxygenating the patient with a tightly-fitting oxygen mask, followed by the sequential administration of pre-determined doses of a hypnotic drug and a rapid-acting neuromuscular blocker. Hypnotics used include thiopental, propofol and etomidate. Neuromuscular-blocking drugs used include suxamethonium (sometimes with a defasciculating dose of vecuronium) and rocuronium.[1] Other drugs may be used in a "modified" RSI. When performing endotracheal intubation, there are several adjunct medications available. No adjunctive medications, when given for their respective indications, have been proven to improve outcomes.[2] Opioids such as alfentanil or fentanyl may be given to attenuate the responses to the intubation process (tachycardia and raised intracranial pressure). This is supposed to have advantages in patients with ischemic heart disease and those with intra-cerebral haemorrhage (e.g. after traumatic head injury or stroke). Lidocaine is also theorized to blunt a rise in intracranial pressure during laryngoscopy, although this remains controversial and its use varies greatly. Atropine may be used to prevent a reflex bradycardia from vagal stimulation during laryngoscopy, especially in young children and infants.

This procedure is usually performed by an anesthesia provider (e.g., physician anesthesiologist, certified registered nurse anesthetist) in surgery and by medical personnel in the emergency department. It may also be performed in the prehospital setting[1] by persons trained to the paramedic level, including flight medics and flight nurses.

Another alternative is intubation of the awake patient under local anesthesia
Local anesthesia

Local anesthesia is any technique to render part of the body insensitive to pain without affecting consciousness. It allows patients to undergo surgical and dentistry procedures with reduced pain and distress....
 using a flexible endoscope
Endoscopy

Endoscopy means looking inside and typically refers to looking inside the body for medical reasons using an instrument called an endoscope....
 or by other means (e.g., using a video laryngoscope). This technique is preferred if difficulties are anticipated, as it allows the patient to breathe spontaneously throughout the procedure, thus ensuring ventilation and oxygenation even in the event of a failed intubation.

Some alternatives to intubation are
  • Tracheostomy - a surgical technique, typically for patients who require long-term respiratory support
  • Cricothyroidotomy - an emergency technique used when intubation is unsuccessful and tracheostomy is not an option.


Because the life of a patient can depend on the success of an intubation, it is important to assess possible obstacles beforehand. The ease of intubation is difficult to predict. One score to assess anatomical difficulties is the Mallampati score
Mallampati score

In anesthesiology, the Mallampati score, also Mallampati classification, is used to predict the ease of intubation. It is determined by looking at the anatomy of the oral cavity; specifically, it is based on the visibility of the base of uvula, faucial pillars and soft palate....
, which is determined by looking at the anatomy
Anatomy

Anatomy is a branch of biology that is the consideration of the body plan. It is a general term that includes human anatomy, animal anatomy and plant anatomy ....
 of the oral cavity and based on the visibility of the base of uvula
Uvula

The uvula is the conic projection from the posterior edge of the middle of the soft palate, composed of connective tissue containing a number of alveolar gland, and some muscular fibers ....
, faucial pillar
Fauces (anatomy)

The fauces , in anatomy, is the posterior part of the mouth, which leads into the pharynx.The fauces are regarded as the two pillars of mucous membrane....
s and the soft palate
Soft palate

The soft palate is the soft biological_tissue constituting the back of the roof of the mouth. The soft palate is distinguished from the hard palate at the front of the mouth in that it does not contain bone....
. It should however be noted that no single score or combination of scores can be trusted to detect all patients who are difficult to intubate. Therefore, persons performing intubation must be familiar with alternative techniques of securing the airways.

History

The first known description of intubation was given in the 1020s by Avicenna
Avicenna

, known as Abu Ali Sina Balkhi or Ibn Sina and commonly known in English by his Latinized name Avicenna , was a Persian people polymath and the foremost Islamic medicine and Early Islamic philosophy of his time....
 in The Canon of Medicine
The Canon of Medicine

The Canon of Medicine is a 14-volume Islamic medicine written by a Science in medieval Islam and physician Avicenna and completed in 1025....
 in order to facilitate breathing. The first detailed report on endotracheal intubation and subsequent artificial respiration of animals was in 1543, when Andreas Vesalius pointed out that the technique could be life-saving. It remained unnoticed however.

In 1869, the German surgeon Friedrich Trendelenburg
Friedrich Trendelenburg

Friedrich Trendelenburg was a Germany surgeon and son of the philosopher Friedrich Adolf Trendelenburg. A number of medical treatments and terminologies have been named after him....
 accomplished the first successful intubation of humans for anaesthesia. He introduced the tube through a temporary tracheotomy
Tracheotomy

Tracheotomy and tracheostomy are surgical procedures on the neck to open a direct airway through an incision in the Vertebrate trachea ....
. In 1878, the Scottish surgeon William MacEwen
William Macewen

Sir William MacEwen Fellow of the Royal Society was a Scotland surgery. He was a pioneer in modern neurosurgery and contributed to the development of bone medical grafting surgery, the surgical treatment of hernia and of pneumonectomy ....
 performed the first oral intubation.

During the First World War, Sir Ivan Magill
Ivan Magill

Ivan Whiteside Magill was an Irish born anaesthetist who is famous for his involvement in much of the innovation and development in modern anaesthesia....
 and Robert Macintosh
Robert Reynolds Macintosh

Sir Robert Reynolds Macintosh was a New Zealand-born anaesthetist.rly lifeMacintosh was baptised with the Maori name, Rewi Rawhiti. He was the youngest son of Charles Nicholson Macintosh, newspaper editor and mayor of Timaru in 1901, and his wife, Lydia Beatrice Thompson....
 achieved profound improvements in the application of intubation. The most used replaceable blade of the laryngoscope is named after Macintosh. The Magill curve of an endotracheal tube and the Magill forceps for positioning the tube during nasal intubation are named after Magill.

Technology


Laryngoscope

Historically, the most common device used for intubation has been the laryngoscope
Laryngoscope

A laryngoscope is a medical instrument that is used to obtain a view of the vocal folds and the glottis, which is the space between the cords....
. Although it has proven sufficient throughout history, many serious problems can arise from its misuse (ex. dental trauma). Newer technologies such as flexible laryngoscopy have fared better in reducing problematic incidence, though the most common cause of intubation trauma is a lack of skill on the part of the laryngoscopist.

The laryngoscope consists of a handle, usually containing batteries, and an interchangeable blade. There are two styles of laryngoscope blades commercially available: the straight blade, and the curved blade. The most popular style of straight blade is the Miller blade, with the Macintosh being the most popular style of curved blade. The technique required is slightly different depending on the style of blade being used; in adults, the Macintosh blade is usually preferred by practitioners, whereas with neonates the Miller blade is the more commonly-used style.

There are many other styles of straight and curved blades, with accessories such as prisms (for enlarging the field of view) and ports for the administration of oxygen. These specialty blades are primarily designed for use by the anaesthetist in the operating room.

Fiber optics

Another common technology used for intubation has been fibre optics, most notably the fibre optic bronchoscope. Intubation over a fibre optic bronchoscope is the preferred method for those who have been deemed difficult to intubate using traditional methods (colloquially known as a "difficult airway".) Using fibre optic bronchoscopy or rhinoscopy still has its drawbacks, however; it requires a significant degree of skill to manipulate the bronchoscope, making this method somewhat inaccessible to practitioners who are not proficient in its use. The equipment has a high initial cost of purchase, is extremely fragile, and very expensive to repair. While traditional intubation with laryngoscopy is ideally achieved in less than 20 seconds, intubation with a bronchoscope can take considerably longer, making its use in highly emergent situations somewhat limited.

Image sensor

The latest technology used to intubate is a computer system utilizing CMOS
CMOS

Complementary metal?oxide?semiconductor , is a major class of integrated circuits. CMOS technology is used in microprocessors, microcontrollers, Static Random Access Memory, and other digital logic circuits....
 image sensor
Image sensor

An image sensor is a device that converts an optical image to an electric signal. It is used mostly in digital cameras and other imaging devices....
s. Visibility failures still occur but to a lesser extent. Also, this technology is still extremely expensive and little used, but progress has been made to reduce visibility failures and costs.

Pediatric Intubation


Most of the general principles of anaesthesia can be applied to children, but there are some significant anatomical and physiological differences between children and adults that can cause problems, especially in neonates and children weighing less than 15 kg.

Route for intubation

For infants and young children oral intubation is easier than nasal. Nasal route carries risk of dislodgement of adenoid tissue and epistaxis, but advantages in good fixation of tube. Because of good fixation, Nasal route is preferable then oral route in children undergoing intensive care and requiring prolonged intubation.

Position of tube

The tip of tube should be at midtrachea (between the clavicles on an AP chest X-ray). The position of the tube is checked by auscultation (equal air entry on each side and, in long-term intubation, by chest X-ray).

Type of tubes

Uncuffed tubes (plain tubes) are commonly used in prepubescent children. In cross section the airway in children is circular which makes plain tracheal tube fits better than cuffed tube.

Cuffed tubes less than 6.0 mm and not inflated are accepted for use in paediatry but generally in children less than 10 years old cuffed tubes are avoided to minimize subglottic swelling and ulceration.

Size of tube


Because the airway of a child is narrow, a small amount of oedema can produce severe obstruction. Oedema can easily be caused by forcing in a tracheal tube that is too tight. (If length of the tube is suspected to be large, immediate changing it to the smaller size is suggestible.)

The correct diameter of the tube is that which results in a small leak at a pressure of about 25 cm of water (the tip should be at midtrachea, between the clavicles on an AP chest Xray).

For normally nourished children more than about 2 years old, the following formula to calculate the internal diameter of the tube is likely to be of the correct size
Formula
Internal diameter of tube (mm) = (age in years ÷ 4) + 4

Rough idea
Roughly correct tube size can be indicated by: Inner Diameter: can be estimated by the size of the child's little finger. (For neonates, 3 mm internal diameter is accepted while for premature infants 2.5 mm internal diameter may be necessary.) Length: can be estimated by doubling the distance from the corner of the child's mouth to the ear canal.
  • Looking from side of the child’s head while holding the upper end of the tube level with the mouth can provide an idea of how far into the chest the tube will go.


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