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Intracrine

 

 
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Intracrine
 
 
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Intracrine refers to a hormone
Hormone

Hormones are chemicals released by cells that affect cells in other parts of the body. Only a small amount of hormone is required to alter cell metabolism....
 that acts inside a cell
Cell (biology)

The cell is the structural and functional unit of all known Life organisms. It is the smallest unit of an organism that is classified as living, and is often called the building bricks of life....
. Steroid hormones act through intracellular (mostly nuclear) receptors and are thus considered as intracrines. In contrast, peptide
Peptide

Peptides are short polymers formed from the linking, in a defined order, of a-amino acids. The link between one amino acid residue and the next is known as an amide chemical bond or a peptide bond....
 or protein
Protein

Proteins are organic compounds made of amino acids arranged in a linear chain and joined together by peptide bonds between the carboxyl and amino groups of adjacent amino acid Residue ....
 hormones generally act as endocrines, autocrines or paracrines by binding to their receptors present on the cell surface. Several peptide/protein hormones or their isoforms also act inside the cell through different mechanisms. These peptide/protein hormones which have intracellular functions are also called intracrines.






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Intracrine refers to a hormone
Hormone

Hormones are chemicals released by cells that affect cells in other parts of the body. Only a small amount of hormone is required to alter cell metabolism....
 that acts inside a cell
Cell (biology)

The cell is the structural and functional unit of all known Life organisms. It is the smallest unit of an organism that is classified as living, and is often called the building bricks of life....
. Steroid hormones act through intracellular (mostly nuclear) receptors and are thus considered as intracrines. In contrast, peptide
Peptide

Peptides are short polymers formed from the linking, in a defined order, of a-amino acids. The link between one amino acid residue and the next is known as an amide chemical bond or a peptide bond....
 or protein
Protein

Proteins are organic compounds made of amino acids arranged in a linear chain and joined together by peptide bonds between the carboxyl and amino groups of adjacent amino acid Residue ....
 hormones generally act as endocrines, autocrines or paracrines by binding to their receptors present on the cell surface. Several peptide/protein hormones or their isoforms also act inside the cell through different mechanisms. These peptide/protein hormones which have intracellular functions are also called intracrines. The term 'intracrine' is thought to be originally coined to represent peptide/protein hormones that also have intracellular actions.

The biological effects produced by intracellular actions are referred as intracrine effects while those produced by binding to cell surface receptors are called endocrine, autocrine or paracrine effects depending on the origin of the hormone. The intracrine effect of some of the peptide/protein hormones are similar to their endocrine, autocrine or paracrine effects; while these effects are different for some other hormones.