Honeymoon (House)
Encyclopedia
"Honeymoon" is the twenty-second and final episode of the first season of House
House (TV series)
House is an American television medical drama that debuted on the Fox network on November 16, 2004. The show's central character is Dr. Gregory House , an unconventional and misanthropic medical genius who heads a team of diagnosticians at the fictional Princeton-Plainsboro Teaching Hospital in...

, which premiered on the Fox
Fox Broadcasting Company
Fox Broadcasting Company, commonly referred to as Fox Network or simply Fox , is an American commercial broadcasting television network owned by Fox Entertainment Group, part of Rupert Murdoch's News Corporation. Launched on October 9, 1986, Fox was the highest-rated broadcast network in the...

 network on May 24, 2005.

Plot

House
Gregory House
Gregory House, M.D., or simply referred to as House, is a fictional antihero and title character of the American television series House, played by Hugh Laurie. He is the Chief of Diagnostic Medicine at the fictional Princeton-Plainsboro Teaching Hospital, where he leads a team of diagnosticians...

 agrees to treat his ex-girlfriend Stacy's (Sela Ward
Sela Ward
Sela Ann Ward is an American movie and television actress, perhaps best known for her television roles as Teddy Reed on the American TV series Sisters and as Lily Manning on Once and Again...

) husband Mark (Currie Graham
Currie Graham
Currie Graham is a Canadian stage, film and television actor. He studied at the American Academy of Dramatic Arts in New York City....

), who refuses to believe there is anything wrong with him. According to Stacy, Mark is suffering from abdominal pain, paranoia, mood swings, and regression, and has passed out twice. Several other doctors have already cleared him. House's team also believe he is fine, and do not understand why House believes Stacy. Cameron
Allison Cameron (House)
Allison Cameron, M.D., is a fictional character on the Fox medical drama House, portrayed by American actress Jennifer Morrison. An immunologist, Cameron was a member of Dr...

 asks him, "What happened to 'Everybody lies'?", referring to House's refusal to take anything at face value. Wilson
James Wilson (House)
James Evan Wilson, M.D., is a fictional character on the Fox medical drama House. He is played by Robert Sean Leonard. The character first appears in the show's pilot episode when he introduces a medical case to Dr. Gregory House, the protagonist of the show. Wilson is Dr. House's only true friend,...

 thinks House is trying to win Stacy back.

All the tests are negative. As a last hope, House orders an exploratory surgery. After spending hours watching the video, he finds abdominal epilepsy, which indicates a neurological problem. The team suggest Alzheimer's disease
Alzheimer's disease
Alzheimer's disease also known in medical literature as Alzheimer disease is the most common form of dementia. There is no cure for the disease, which worsens as it progresses, and eventually leads to death...

 and encephalitis
Encephalitis
Encephalitis is an acute inflammation of the brain. Encephalitis with meningitis is known as meningoencephalitis. Symptoms include headache, fever, confusion, drowsiness, and fatigue...

. Cameron tests for Alzheimer's and finds nothing. Meanwhile, Foreman
Eric Foreman
Eric Foreman, M.D., is a fictional character on the Fox medical drama House. He is portrayed by Omar Epps.-Background:A neurologist, Foreman was a member of Dr. Gregory House's handpicked team of specialists at Princeton-Plainsboro Teaching Hospital's Diagnostic Medicine Department...

 and Chase
Robert Chase
Dr. Robert Chase is a fictional character on the Fox medical drama House. He is portrayed by Jesse Spencer. His character was a part of the team of diagnosticians who worked under Gregory House until the end of the third season when House fires him. However, he was then re-hired in season 6...

 go to Short Hills, New Jersey
Short Hills, New Jersey
Short Hills is an unincorporated area located within the township of Millburn, in Essex County, New Jersey, United States. It is a popular commuter town for residents who work in New York City...

, search Stacy and Mark's home, and find a bottle of amphetamines, which turn out to have been confiscated from a student (Mark is a high school guidance counselor). In full view of his team, House slips the vial of narcotics into his pocket. The diagnostic team also note that Mark had switched from mountain biking to yoga, which Chase suggests could indicate back pain, but House dismisses as a symptom of "getting older". House and Foreman test Mark's memory, but find no problems. House grills Mark about Stacy, to which he gives a long, rambling answer about how they honeymooned in Paris. Stacy is furious, and House admits he does not know what is wrong, but refuses to give up.

Mark develops paralysis in his arms and legs. House decides to treat Mark for Guillain-Barré syndrome
Guillain-Barré syndrome
Guillain–Barré syndrome , sometimes called Landry's paralysis, is an acute inflammatory demyelinating polyneuropathy , a disorder affecting the peripheral nervous system. Ascending paralysis, weakness beginning in the feet and hands and migrating towards the trunk, is the most typical symptom...

, while Mark starts showing paranoia. His throat appears to close up, but as Cameron is about to intubate, House notices Mark's O2 stats are normal and concludes he is suffering from a panic attack, which he treats with Ativan.

House confides to Wilson he is happy Mark is not responding to treatment, and is unsure if it is because he wants to be with Stacy, or if he wants her to suffer. When he talks to her, he finds out she and Mark never honeymooned in Paris, even though the brain scan showed he was telling the truth. House realizes Mark is delusional, and comes up with a diagnosis: acute intermittent porphyria
Acute intermittent porphyria
Acute intermittent porphyria is a rare autosomal dominant metabolic disorder affecting the production of heme, the oxygen-binding prosthetic group of hemoglobin. It is characterized by a deficiency of the enzyme porphobilinogen deaminase. Acute intermittent porphyria is the second most common...

, which implies that the switch to the indoor activity of yoga was relevant, as a symptom of the disease is sensitivity to light. Unfortunately, aside from a time-consuming genetic test for mutations in the gene HMB synthase, the only way to confirm AIP is through a urine sample made during an attack. Since there is no way to predict when this will happen, House wants to give Mark a drug cocktail that could set off an attack. Despite Stacy's agreement to the treatment, Mark refuses the test. House refuses to proceed against the patient's wishes. Stacy accuses him of setting up with Mark exactly the same situation she had previously faced with House (as told in the previous episode), except that she asserts that unlike House, Mark will forgive her. Despite his team's attempt to stop him and against the patient's wishes, House injects Mark with the drug cocktail, which triggers the attack. House extracts urine directly from Mark's bladder and performs a test on it using ultraviolet light. When his urine turns purple under the light, House is able to confirm and treat AIP.

Stacy admits she is still in love with House, but cannot be with him, and she believes Mark is there for her more. Cuddy
Lisa Cuddy
Dr. Lisa Cuddy, M.D., is a fictional character on the Fox medical drama House. She is portrayed by Lisa Edelstein. Cuddy was the Dean of Medicine and hospital administrator of the fictional Princeton-Plainsboro Teaching Hospital in New Jersey. She also becomes House's love interest through the...

 tells House she is considering hiring Stacy, to which he replies that he has no problem with the idea. In the closing scene, House attempts to walk without his cane at home. Experiencing pain, House opens the vial of narcotics he stole earlier and takes the pill.

External links

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