Highway 10 is an expressway in the South District of Israel

Israel

The State of Israel is a parliamentary republic located in the Middle East, along the eastern shore of the Mediterranean Sea...

. It is one of the longest roads in Israel, extending for nearly the entire border of Israel with Egypt

Egypt

Egypt , officially the Arab Republic of Egypt, Arabic: , is a country mainly in North Africa, with the Sinai Peninsula forming a land bridge in Southwest Asia. Egypt is thus a transcontinental country, and a major power in Africa, the Mediterranean Basin, the Middle East and the Muslim world...

 from the Gaza Strip

Gaza Strip

thumb|Gaza city skylineThe Gaza Strip lies on the Eastern coast of the Mediterranean Sea. The Strip borders Egypt on the southwest and Israel on the south, east and north. It is about long, and between 6 and 12 kilometres wide, with a total area of...

 in the north to Sayarim junction in the south.

Description of the route from north to south

The route begins in the north with the communities of Hevel Eshkol in the west, nearest to the Sinai Desert. The northern terminus is the intersection with Route 232 near Kerem Shalom

Kerem Shalom

Kerem Shalom is a kibbutz in the Eshkol Regional Council and a border crossing near the meeting of the Gaza Strip-Israel-Egypt borders.- Kibbutz :The kibbutz was founded in 1966 adjacent to the triborder area by members of Hashomer Hatzair...

. From there it continues south adjacent to the border with Egypt. It passes by Nitzana

Nitzana (village)

Nitzana is an educational youth village and communal settlement in the western Negev desert in Israel, adjacent to the Egyptian border. It is named for the nearby Nabataean city of Nitzana and gives its name to the Nitzana Border Crossing, formerly Auja al-Hafir.This settlement was founded in 1987...

 and the Nitzana border crossing.

Highway 10 intersects with Route 211, which leads east toward Yeruham

Yeruham

Yeruham is a town in the Southern District of Israel, in the Negev desert. It covers 38,584 dunams and had a population of 9,400 in 2006. It is named after the Biblical Jeroham. The mayor of Yeruham was Amram Mitzna but his term ended in early 2011, and he was succeeded by Michael Bitton of...

 and Sde Boker

Sde Boker

Sde Boker is a kibbutz in the Negev desert of southern Israel. Best known as the retirement home of Israel's first Prime Minister, David Ben-Gurion, it falls under the jurisdiction of Ramat HaNegev Regional Council.-History:...

. Farther south, Highway 10 intersects with Route 171

Route 171 (Israel)

Route 171 is a regional east-west highway in southern Israel. It is the only east-west highway in the Negev Mountains. It is 33 km long. It goes from Har Harif junction on Highway 10 adjacent to Israel's border with Egypt to HaRuhot junction with Highway 40 about 5 km north of Mitzpe Ramon...

, which leads east toward Mizpe Ramon.

The route continues south until Sayarim junction, where it meets Highway 12

Highway 12 (Israel)

Highway 12 is an expressway in the South District of Israel. It surrounds the mountains of Eilat from the north and west, and it connects Eilat to Highway 10 and Highway 40, which lead toward central Israel...

 in the mountains near Eilat. Highway 12 continues south to Eilat.