Heuser's membrane
Encyclopedia
Heuser's membrane is a short lived combination of hypoblast
Hypoblast
The hypoblast is a tissue type that forms from the inner cell mass. It lies beneath the epiblast and consists of small cuboidal cells.Extraembryonic endoderm is derived from hypoblast.-External links:...

 cells and extracellular matrix
Extracellular matrix
In biology, the extracellular matrix is the extracellular part of animal tissue that usually provides structural support to the animal cells in addition to performing various other important functions. The extracellular matrix is the defining feature of connective tissue in animals.Extracellular...

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At day 9-10, at the abembryonic pole, cells from the cytotrophoblast flatten to create a thin exocoelomic membrane known as Heuser’s Membrane. It surrounds the exocoelomic cavity.i.e. it lines the inner surface of the cytotrophoblast.

At days 11 to 12, there is further delineation of the trophoblastic cells giving rise to a layer of loosely arranged cells that inserts between Heuser’s membrane and both syncytio and cytotrophoblast.
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