Hershey-Chase experiment
Overview
 
The Hershey–Chase experiments were a series of experiment
Experiment
An experiment is a methodical procedure carried out with the goal of verifying, falsifying, or establishing the validity of a hypothesis. Experiments vary greatly in their goal and scale, but always rely on repeatable procedure and logical analysis of the results...

s conducted in 1952 by Alfred Hershey
Alfred Hershey
Alfred Day Hershey was an American Nobel Prize-winning bacteriologist and geneticist.He was born in Owosso, Michigan and received his B.S. in chemistry at Michigan State University in 1930 and his Ph.D. in bacteriology in 1934, taking a position shortly thereafter at the Department of Bacteriology...

 and Martha Chase
Martha Chase
Martha Cowles Chase , also known as Martha C. Epstein, was an American geneticist famously known for being a member of the 1952 team which experimentally showed that DNA rather than protein is the genetic material of life. She was greatly respected as a geneticist. Chase was born in 1927 in...

, which helped to confirm that DNA
DNA
Deoxyribonucleic acid is a nucleic acid that contains the genetic instructions used in the development and functioning of all known living organisms . The DNA segments that carry this genetic information are called genes, but other DNA sequences have structural purposes, or are involved in...

 was the genetic material. While DNA had been known to biologist
Biologist
A biologist is a scientist devoted to and producing results in biology through the study of life. Typically biologists study organisms and their relationship to their environment. Biologists involved in basic research attempt to discover underlying mechanisms that govern how organisms work...

s since 1869, a few scientists still assumed at the time that protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

s carried the information for inheritance. In their experiments, Hershey and Chase showed that when bacteriophage
Bacteriophage
A bacteriophage is any one of a number of viruses that infect bacteria. They do this by injecting genetic material, which they carry enclosed in an outer protein capsid...

s, which are composed of DNA and protein, infect bacteria, their DNA enters the host bacterial cell, but most of their protein does not.
 
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