Glisodin is a nutritional supplement based on two constituents:
- Cantaloupe
Cantaloupe refers to two varieties of Cucumis melo , which is a species in the family Cucurbitaceae, which includes nearly all melons and squashes. Cantaloupes range in size from 0.5 kg to 5.0 kg...
extract, which typically contains high quantities of the enzymeEnzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process are called substrates, and the enzyme converts them into different molecules, called the products. Almost all processes in a biological cell need enzymes to occur at...
superoxide dismutaseSuperoxide dismutases are a class of enzymes that catalyze the dismutation of superoxide into oxygen and hydrogen peroxide. As such, they are an important antioxidant defense in nearly all cells exposed to oxygen...
(SOD)
- Gliadin
Gliadin is a glycoprotein present in wheat and several other cereals within the grass genus Triticum. Gliadins are prolamins and are separated on the basis of electrophoretic mobility and isoelectric focusing.- Types :...
, a wheat protein designProtein design is the design of new protein molecules from scratch, or the deliberate design of a new molecule by making calculated variations on a known structure. The number of possible amino acid sequences is enormous, but only a subset of these sequences will fold reliably and quickly to a...
ed to protect SOD during the digestive process
As
oxygenOxygen Oxygen Oxygen (acid, literally "sharp", from the taste of acids) and -γενής (-genēs) (producer, literally begetter) is the element with atomic number 8 and represented by the symbol O...
metabolizes in the body, potentially harmful
reactive oxygen speciesReactive oxygen species are free radicals that contain the oxygen atom. They are very small molecules that include oxygen ions and peroxides and can be either inorganic or organic. They are highly reactive due to the presence of unpaired valence shell electrons.ROS form as a natural byproduct of...
(ROS) are created. The human body implements an
antioxidantAn antioxidant is a molecule capable of slowing or preventing the oxidation of other molecules. Oxidation is a chemical reaction that transfers electrons from a substance to an oxidizing agent. Oxidation reactions can produce free radicals, which start chain reactions that damage cells...
defense system to protect against ROS.
Glisodin is a nutritional supplement based on two constituents:
- Cantaloupe
Cantaloupe refers to two varieties of Cucumis melo , which is a species in the family Cucurbitaceae, which includes nearly all melons and squashes. Cantaloupes range in size from 0.5 kg to 5.0 kg...
extract, which typically contains high quantities of the enzymeEnzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process are called substrates, and the enzyme converts them into different molecules, called the products. Almost all processes in a biological cell need enzymes to occur at...
superoxide dismutaseSuperoxide dismutases are a class of enzymes that catalyze the dismutation of superoxide into oxygen and hydrogen peroxide. As such, they are an important antioxidant defense in nearly all cells exposed to oxygen...
(SOD)
- Gliadin
Gliadin is a glycoprotein present in wheat and several other cereals within the grass genus Triticum. Gliadins are prolamins and are separated on the basis of electrophoretic mobility and isoelectric focusing.- Types :...
, a wheat protein designProtein design is the design of new protein molecules from scratch, or the deliberate design of a new molecule by making calculated variations on a known structure. The number of possible amino acid sequences is enormous, but only a subset of these sequences will fold reliably and quickly to a...
ed to protect SOD during the digestive process
Background
As
oxygenOxygen Oxygen Oxygen (acid, literally "sharp", from the taste of acids) and -γενής (-genēs) (producer, literally begetter) is the element with atomic number 8 and represented by the symbol O...
metabolizes in the body, potentially harmful
reactive oxygen speciesReactive oxygen species are free radicals that contain the oxygen atom. They are very small molecules that include oxygen ions and peroxides and can be either inorganic or organic. They are highly reactive due to the presence of unpaired valence shell electrons.ROS form as a natural byproduct of...
(ROS) are created. The human body implements an
antioxidantAn antioxidant is a molecule capable of slowing or preventing the oxidation of other molecules. Oxidation is a chemical reaction that transfers electrons from a substance to an oxidizing agent. Oxidation reactions can produce free radicals, which start chain reactions that damage cells...
defense system to protect against ROS. In the event that these defenses are overpowered by the ROS,
cellThe cell is the basic structural and functional unit of all known living organisms. It is the smallest unit of an organism that is classified as living, and is often called the building block of life. The Alberts text discusses how the "cellular building blocks" move to shape developing embryos...
damage results (which is a major cause of aging in the body).
Superoxide dismutaseSuperoxide dismutases are a class of enzymes that catalyze the dismutation of superoxide into oxygen and hydrogen peroxide. As such, they are an important antioxidant defense in nearly all cells exposed to oxygen...
(SOD) helps to slow the creation of ROS, ultimately playing a key role in the defense against
cellThe cell is the basic structural and functional unit of all known living organisms. It is the smallest unit of an organism that is classified as living, and is often called the building block of life. The Alberts text discusses how the "cellular building blocks" move to shape developing embryos...
damage. However, due to a very fragile molecular structure, it is particularly prone to damage from stomach acids and digestive enzymes when taken orally.
GliadinGliadin is a glycoprotein present in wheat and several other cereals within the grass genus Triticum. Gliadins are prolamins and are separated on the basis of electrophoretic mobility and isoelectric focusing.- Types :...
, which is well-known as a
carrier proteinCarrier proteins are proteins that transport a specific substance or group of substances through intracellular compartments or in extracellular fluids or else across the cell membrane...
for controlled drug release, helps to protect SOD. The union of the two is known as GliSODin, and is "the only proven orally effective delivery of SOD."
Research
A wide range of clinical research has been undertaken to study glisodin's antioxidant capacities. This has extended into a wide range of applications, including protection from ultraviolet radiation, athletic performance, cardiovascular health, ischemia and reperfusion injury.
A group of researchers in France and Germany led by Dr. Claus Muth concluded that glisodin is helpful in protecting against DNA damage caused by hyperbaric oxidation. A 2005 study at Rutgers University also concluded that glisodin is helpful in enhancing athletic performance while minimizing fatigue.
External links