Galactosyltransferase
Encyclopedia
Galactosyltransferase is a type of glycosyltransferase
Glycosyltransferase
Glycosyltransferases are enzymes that act as a catalyst for the transfer of a monosaccharide unit from an activated nucleotide sugar to a glycosyl acceptor molecule, usually an alcohol....

 which catalyzes the transfer of galactose
Galactose
Galactose , sometimes abbreviated Gal, is a type of sugar that is less sweet than glucose. It is a C-4 epimer of glucose....

. An example is B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase
B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase
B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase is a galactosyltransferase.It is classified under ....

.

The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferases using nucleotide diphospho-sugar, nucleotide monophospho-sugar and sugar phosphates and related proteins into distinct sequence based families has been described. This classification is available on the CAZy (Carbohydrate-Active EnZymes) web site. The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences, several of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form 'clans'.

Glycosyltransferase family 31 (CAZY GH_31) comprises enzymes with a number of known activities; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase ; beta-1,3-galactosyltransferase ; fucose-specific beta-1,3-N-acetylglucosaminyltransferase ; globotriosylceramide beta-1,3-GalNAc transferase .

Human galactosyltransferases

B3GALNT1
B3GALNT1
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the B3GALNT1 gene.-Further reading:...

; B3GALNT2; B3GALT1; B3GALT2; B3GALT4
B3GALT4
Beta-1,3-galactosyltransferase 4 is an enzyme that in humans is encoded by the B3GALT4 gene.-Further reading:...

; B3GALT5
B3GALT5
Beta-1,3-galactosyltransferase 5 is an enzyme that in humans is encoded by the B3GALT5 gene.-Further reading:...

; B3GALT6; B3GNT2
B3GNT2
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 is an enzyme that in humans is encoded by the B3GNT2 gene.-Further reading:...

; B3GNT3
B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 is an enzyme that in humans is encoded by the B3GNT3 gene.-Further reading:...

; B3GNT4; B3GNT5; B3GNT6; B3GNT7; B3GNT8;
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