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GNA (nucleic acid)
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Glycerol nucleic acid (GNA) is a polymer similar to DNA or RNA but differing in the composition of its "backbone". GNA is not known to occur naturally.
The 2,3-dihydroxypropylnucleoside analogues were first prepared by Ueda et al (1971). Soon thereafter it was shown that phosphate-linked oligomers of the analogues did in fact exhibit hypochromicity in the presence of RNA and DNA in solution (Seita et al 1972).
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Glycerol nucleic acid (GNA) is a polymer similar to DNA or RNA but differing in the composition of its "backbone". GNA is not known to occur naturally.
The 2,3-dihydroxypropylnucleoside analogues were first prepared by Ueda et al (1971). Soon thereafter it was shown that phosphate-linked oligomers of the analogues did in fact exhibit hypochromicity in the presence of RNA and DNA in solution (Seita et al 1972). The preparation of the polymers was later described by Cook et al (1995, 1999) and Acevedo and Andrews (1996). The GNA-GNA self-pairing described by Zhang and Meggers is however novel, and the specificity of interaction well-demonstrated, the molecules themselves.
DNA and RNA have a deoxyribose and ribose sugar backbone, respectively, whereas GNA's backbone is composed of repeating glycerol units linked by phosphodiester bonds. The glycerol molecule has just three carbon atoms and still shows Watson-Crick base pairing. Interestingly, the Watson-Crick base pairing is much more stable in GNA than its natural counterparts DNA and RNA as it requires a high temperature to melt a duplex of GNA. It is possibly the simplest of the nucleic acids, so making it a hypothetical precursor to RNA.
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