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Fructose 2,6-bisphosphatase

 

 
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Fructose 2,6-bisphosphatase
 
 
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Fructose-2,6-bisphosphatase is an enzyme
Enzyme

Enzymes are biomolecules that catalysis chemical reactions. Almost all enzymes are proteins. In enzymatic reactions, the molecules at the beginning of the process are called Substrate , and the enzyme converts them into different molecules, the products....
 that catalyzes the following reaction:

fructose-2,6-bisphosphate + H2O
H2O

H2O is the chemical formula for Water and is also used as an abbreviation for the word "water". H2O or H2O It may also refer to:...
 ---> fructose 6-phosphate
Fructose 6-phosphate

Fructose 6-phosphate is fructose sugar phosphorylated on carbon 6 . The ?-D-form of this compound is very common in cell . The vast majority of glucose and fructose entering a cell will become converted to this at some point....
 + phosphate
Phosphate

A phosphate, an inorganic chemical, is a Salt of phosphoric acid. Inorganic phosphates are mining to obtain phosphorus for use in agriculture and industry....
 ion

Fructose-2,6-bisphosphatase is important in regulation of gluconeogenesis
Gluconeogenesis

Gluconeogenesis is a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as lactic acid, glycerol, and glucogenic amino acids....
 & glycolysis
Glycolysis

Glycolysis is the metabolic pathway that converts glucose, C6H12O6, into pyruvate, C3H5O3-....
 as it catalyzes the dephosphorylation of fructose-2,6-bisphosphate. Because fructose-2,6-bisphosphate activates phosphofructokinase-1 (a critical enzyme in glycolysis
Glycolysis

Glycolysis is the metabolic pathway that converts glucose, C6H12O6, into pyruvate, C3H5O3-....
) and inhibits fructose-1,6-bisphosphatase (a critical enzyme in gluconeogenesis
Gluconeogenesis

Gluconeogenesis is a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as lactic acid, glycerol, and glucogenic amino acids....
), the activity of fructose-2,6-bisphosphatase decreases glycolysis and increases gluconeogenesis.

Fructose-2,6-bisphosphatase is subject to product inhibition by fructose 6-phosphate
Fructose 6-phosphate

Fructose 6-phosphate is fructose sugar phosphorylated on carbon 6 . The ?-D-form of this compound is very common in cell . The vast majority of glucose and fructose entering a cell will become converted to this at some point....
.






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Fructose-2,6-bisphosphatase is an enzyme
Enzyme

Enzymes are biomolecules that catalysis chemical reactions. Almost all enzymes are proteins. In enzymatic reactions, the molecules at the beginning of the process are called Substrate , and the enzyme converts them into different molecules, the products....
 that catalyzes the following reaction:

fructose-2,6-bisphosphate + H2O
H2O

H2O is the chemical formula for Water and is also used as an abbreviation for the word "water". H2O or H2O It may also refer to:...
 ---> fructose 6-phosphate
Fructose 6-phosphate

Fructose 6-phosphate is fructose sugar phosphorylated on carbon 6 . The ?-D-form of this compound is very common in cell . The vast majority of glucose and fructose entering a cell will become converted to this at some point....
 + phosphate
Phosphate

A phosphate, an inorganic chemical, is a Salt of phosphoric acid. Inorganic phosphates are mining to obtain phosphorus for use in agriculture and industry....
 ion

Fructose-2,6-bisphosphatase is important in regulation of gluconeogenesis
Gluconeogenesis

Gluconeogenesis is a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as lactic acid, glycerol, and glucogenic amino acids....
 & glycolysis
Glycolysis

Glycolysis is the metabolic pathway that converts glucose, C6H12O6, into pyruvate, C3H5O3-....
 as it catalyzes the dephosphorylation of fructose-2,6-bisphosphate. Because fructose-2,6-bisphosphate activates phosphofructokinase-1 (a critical enzyme in glycolysis
Glycolysis

Glycolysis is the metabolic pathway that converts glucose, C6H12O6, into pyruvate, C3H5O3-....
) and inhibits fructose-1,6-bisphosphatase (a critical enzyme in gluconeogenesis
Gluconeogenesis

Gluconeogenesis is a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as lactic acid, glycerol, and glucogenic amino acids....
), the activity of fructose-2,6-bisphosphatase decreases glycolysis and increases gluconeogenesis.

Fructose-2,6-bisphosphatase is subject to product inhibition by fructose 6-phosphate
Fructose 6-phosphate

Fructose 6-phosphate is fructose sugar phosphorylated on carbon 6 . The ?-D-form of this compound is very common in cell . The vast majority of glucose and fructose entering a cell will become converted to this at some point....
. Fructose-2,6-bisphosphatase also undergoes addition of a phosphate group to a single serine
Serine

Serine is an organic compound with the chemical formula hydrogenoxygen2carbonCHCH2OH....
 residue by cAMP-dependent protein kinase
CAMP-dependent protein kinase

In cell biology, protein kinase A refers to a family of enzymes whose activity is dependent on the level of cyclic AMP in the cell. PKA is also known as cAMP-dependent protein kinase )....
 (known as covalent modification), which activates (increases catalytic activity) of Fructose-2,6-bisphosphatase.

See also

  • Phosphofructokinase 2


External links

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