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Flux (biochemistry)

Flux (biochemistry)

Overview
Flux, or metabolic flux is the rate of turnover of molecules through a metabolic pathway
Metabolic pathway
-Cellular respiration:Several distinct but linked metabolic pathways are used by cells to transfer the energy released by breakdown of fuel molecules to ATP...

. Flux is regulated by the enzymes involved in a pathway. Within cell
Cell (biology)
The cell is the basic structural and functional unit of all known living organisms. It is the smallest unit of an organism that is classified as living, and is often called the building block of life. The Alberts text discusses how the "cellular building blocks" move to shape developing embryos...

s regulation of flux is vital for all metabolic pathways to regulate the metabolic pathway's activity under different conditions. Flux is therefore of great interest in metabolic network modelling
Metabolic network modelling
Metabolic network reconstruction and simulation allows for an in depth insight into comprehending the molecular mechanisms of a particular organism, especially correlating the genome with molecular physiology...

, where it is analysed via flux balance analysis
Flux balance analysis
-Introduction:Flux balance analysis has been shown to be a very useful technique for analysis of metabolic capabilities of cellular systems. Living organisms survive, grow or strive with the help of the available nutrients they find in their environment. They transform the nutrients into molecules...

.
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Encyclopedia
Flux, or metabolic flux is the rate of turnover of molecules through a metabolic pathway
Metabolic pathway
-Cellular respiration:Several distinct but linked metabolic pathways are used by cells to transfer the energy released by breakdown of fuel molecules to ATP...

. Flux is regulated by the enzymes involved in a pathway. Within cell
Cell (biology)
The cell is the basic structural and functional unit of all known living organisms. It is the smallest unit of an organism that is classified as living, and is often called the building block of life. The Alberts text discusses how the "cellular building blocks" move to shape developing embryos...

s regulation of flux is vital for all metabolic pathways to regulate the metabolic pathway's activity under different conditions. Flux is therefore of great interest in metabolic network modelling
Metabolic network modelling
Metabolic network reconstruction and simulation allows for an in depth insight into comprehending the molecular mechanisms of a particular organism, especially correlating the genome with molecular physiology...

, where it is analysed via flux balance analysis
Flux balance analysis
-Introduction:Flux balance analysis has been shown to be a very useful technique for analysis of metabolic capabilities of cellular systems. Living organisms survive, grow or strive with the help of the available nutrients they find in their environment. They transform the nutrients into molecules...

.