Evoked potential
Encyclopedia
An evoked potential is an electrical potential recorded from the nervous system
Nervous system
The nervous system is an organ system containing a network of specialized cells called neurons that coordinate the actions of an animal and transmit signals between different parts of its body. In most animals the nervous system consists of two parts, central and peripheral. The central nervous...

 of a human
Human
Humans are the only living species in the Homo genus...

 or other animal
Animal
Animals are a major group of multicellular, eukaryotic organisms of the kingdom Animalia or Metazoa. Their body plan eventually becomes fixed as they develop, although some undergo a process of metamorphosis later on in their life. Most animals are motile, meaning they can move spontaneously and...

 following presentation of a stimulus
Stimulus (physiology)
In physiology, a stimulus is a detectable change in the internal or external environment. The ability of an organism or organ to respond to external stimuli is called sensitivity....

, as distinct from spontaneous potentials as detected by electroencephalography
Electroencephalography
Electroencephalography is the recording of electrical activity along the scalp. EEG measures voltage fluctuations resulting from ionic current flows within the neurons of the brain...

 (EEG) or electromyography
Electromyography
Electromyography is a technique for evaluating and recording the electrical activity produced by skeletal muscles. EMG is performed using an instrument called an electromyograph, to produce a record called an electromyogram. An electromyograph detects the electrical potential generated by muscle...

 (EMG).

Evoked potential amplitude
Amplitude
Amplitude is the magnitude of change in the oscillating variable with each oscillation within an oscillating system. For example, sound waves in air are oscillations in atmospheric pressure and their amplitudes are proportional to the change in pressure during one oscillation...

s tend to be low, ranging from less than a microvolt to several microvolts, compared to tens of microvolts for EEG, millivolts for EMG, and often close to a volt for ECG
Electrocardiogram
Electrocardiography is a transthoracic interpretation of the electrical activity of the heart over a period of time, as detected by electrodes attached to the outer surface of the skin and recorded by a device external to the body...

. To resolve these low-amplitude potentials against the background of ongoing EEG, ECG, EMG, and other biological signals and ambient noise, signal averaging is usually required. The signal is time-locked to the stimulus and most of the noise
Noise
In common use, the word noise means any unwanted sound. In both analog and digital electronics, noise is random unwanted perturbation to a wanted signal; it is called noise as a generalisation of the acoustic noise heard when listening to a weak radio transmission with significant electrical noise...

 occurs randomly, allowing the noise to be averaged out with averaging of repeated responses.

Signals can be recorded from cerebral cortex
Cerebral cortex
The cerebral cortex is a sheet of neural tissue that is outermost to the cerebrum of the mammalian brain. It plays a key role in memory, attention, perceptual awareness, thought, language, and consciousness. It is constituted of up to six horizontal layers, each of which has a different...

, brain stem
Brain stem
In vertebrate anatomy the brainstem is the posterior part of the brain, adjoining and structurally continuous with the spinal cord. The brain stem provides the main motor and sensory innervation to the face and neck via the cranial nerves...

, spinal cord
Spinal cord
The spinal cord is a long, thin, tubular bundle of nervous tissue and support cells that extends from the brain . The brain and spinal cord together make up the central nervous system...

 and peripheral nerve
Peripheral nervous system
The peripheral nervous system consists of the nerves and ganglia outside of the brain and spinal cord. The main function of the PNS is to connect the central nervous system to the limbs and organs. Unlike the CNS, the PNS is not protected by the bone of spine and skull, or by the blood–brain...

s. Usually the term "evoked potential" is reserved for responses involving either recording from, or stimulation of, central nervous system structures. Thus evoked compound motor action potentials (CMAP) or sensory nerve action potentials (SNAP) as used in nerve conduction studies
Nerve conduction study
A nerve conduction study is a test commonly used to evaluate the function, especially the ability of electrical conduction, of the motor and sensory nerves of the human body.Nerve conduction velocity is a common measurement made during this test...

 (NCS) are generally not thought of as evoked potentials, though they do meet the above definition.

Sensory evoked potentials

Sensory evoked potentials (SEP) are recorded from the central nervous system
Central nervous system
The central nervous system is the part of the nervous system that integrates the information that it receives from, and coordinates the activity of, all parts of the bodies of bilaterian animals—that is, all multicellular animals except sponges and radially symmetric animals such as jellyfish...

 following stimulation of sense organs (for example, visual evoked potentials elicited by a flashing light or changing pattern on a monitor; auditory
Auditory system
The auditory system is the sensory system for the sense of hearing.- Outer ear :The folds of cartilage surrounding the ear canal are called the pinna...

 evoked potentials by a click or tone stimulus presented through earphones) or by tactile or somatosensory evoked potential (SSEP) elicited by tactile or electrical stimulation of a sensory or mixed nerve in the periphery
Peripheral nervous system
The peripheral nervous system consists of the nerves and ganglia outside of the brain and spinal cord. The main function of the PNS is to connect the central nervous system to the limbs and organs. Unlike the CNS, the PNS is not protected by the bone of spine and skull, or by the blood–brain...

. They have been widely used in clinical diagnostic medicine since the 1970s, and also in intraoperative neurophysiology monitoring (IONM), also known as surgical neurophysiology.

There are three kinds of evoked potentials in widespread clinical use: auditory evoked potentials, usually recorded from the scalp but originating at brainstem level; visual evoked potentials, and somatosensory evoked potentials, which are elicited by electrical stimulation of peripheral nerve. See below.

Long and Allen reported the abnormal BAEPs in an alcoholic woman who recovered from Ondine's curse
Ondine's curse
Ondine's Curse, also called congenital central hypoventilation syndrome or primary alveolar hypoventilation, is a respiratory disorder that is fatal if untreated...

. These investigators hypothesized that their patient's brainstem was poisoned, but not destroyed, by her chronic alcoholism.

Steady-state evoked potential

An evoked potential is the electrical response of the brain to a sensory stimulus. Regan constructed an analogue Fourier series analyzer to record harmonics of the evoked potential to flickering (sinusoidally modulated) light but, rather than integrating the sine and cosine products, fed them to a two-pen recorder via lowpass filters. This allowed him to demonstrate that the brain attained a steady-state regime in which the amplitude and phase of the harmonics (frequency components) of the response were approximately constant over time. By analogy with the steady-state response of a resonant circuit that follows the initial transient response he defined an idealized steady-state evoked potential (SSEP) as a form of response to repetitive sensory stimulation in which the constituent frequency components of the response remain constant with time in both amplitude and phase. Although this definition implies a series of identical temporal waveforms, it is more helpful to define the SSEP in terms of the frequency components that are an alternative description of the time-domain waveform, because different frequency components can have quite different properties For example, the properties of the high-frequency flicker SSEP (whose peak amplitude is near 40–50 Hz) correspond to the properties of the subsequently discovered magnocellular neurons in the retina of the macaque monkey, while the properties of the medium-frequency flicker SSEP ( whose amplitude peak is near 15–20 Hz) correspond to the properties of parvocellular neurons. Since a SSEP can be completely described in terms of the amplitude and phase of each frequency component it can be quantified more unequivocally than an averaged transient evoked potential.

It is sometimes said that SSEPs are elicited only by stimuli of high repetition frequency, but this is not generally correct. In principle, a sinusoidally modulated stimulus can elicit a SSEP even when its repetition frequency is low. Because of the high-frequency rolloff of the SSEP, high frequency stimulation can produce a near-sinusoidal SSEP waveform , but this is not germane to the definition of a SSEP.
By using zoom-FFT to record SSEPs at the theoretical limit of spectral resolution ΔF (where ΔF in Hz is the reciprocal of the recording duration in seconds) Regan and Regan discovered that the amplitude and phase variability of the SSEP can be sufficiently small that the bandwidth of the SSEP’s constituent frequency components can be at the theoretical limit of spectral resolution up to at least a 500 second recording duration (0.002 Hz in this case).
Repetitive sensory stimulation elicits a steady-state magnetic brain response that can be analysed in the same way as the SSEP.

The "simultaneous stimulation" technique

This technique allows several (e.g., four) SSEPs to be recorded simultaneously from any given location on the scalp. Different sites of stimulation or different stimuli can be tagged with slightly different frequencies that are virtually identical to the brain, but easily separated by Fourier series analyzers. For example, when two unpatterned lights are modulated at slightly different frequencies (F1 and F2) and superimposed, multiple nonlinear cross-modulation components of frequency (mF1 ± nF2) are created in the SSEP, where m and n are integers. These components allow nonlinear processing in the brain to be investigated. By frequency-tagging two superimposed gratings, spatial frequency and orientation tuning properties of the brain mechanisms that process spatial form can be isolated and studied. Stimuli of different sensory modalities can also be tagged. For example, a visual stimulus was flickered at Fv Hz and a simultaneously-presented auditory tone was amplitude modulated at Fa Hz. The existence of a (2Fv + 2Fa) component in the evoked magnetic brain response demonstrated an audio-visual convergence area in the human brain, and the distribution of this response over the head allowed this brain area to be localized. More recently, frequency tagging has been extended from studies of sensory processing to studies of selective attention and of consciousness.

The “sweep” technique

The sweep technique is a hybrid frequency domain/time domain technique. A plot of, for example, response amplitude versus the check size of a stimulus checkerboard pattern plot can be obtained in 10 seconds, far faster than when time-domain averaging is used to record an evoked potential for each of several check sizes.
In the original demonstration of the technique the sine and cosine products were fed through lowpass filters (as when recording a SSEP ) while viewing a pattern of fine checks whose black and white squares exchanged place six times per second. Then the size of the squares was progressively increased so as to give a plot of evoked potential amplitude versus check size (hence “sweep”). Subsequent authors have implemented the sweep technique by using computer software to increment the spatial frequency of a grating in a series of small steps and to compute a time-domain average for each discrete spatial frequency.
A single sweep may be adequate or it may be necessary to average the graphs obtained in several sweeps with the averager triggered by the sweep cycle. Averaging 16 sweeps can improve the signal-to-noise ratio of the graph by a factor of four.
The sweep technique has proved useful in measuring rapidly-adapting visual processes and also for recording from babies, where recording duration is necessarily short. Norcia and Tyler have used the technique to document the development of visual acuity and contrast sensitivity through the first years of life. They have emphasized that, in diagnosing abnormal visual development, the more precise the developmental norms, the more sharply can the abnormal be distinguished from the normal, and to that end have documented normal visual development in a large group of infants. For many years the sweep technique has been used in paediatric ophthalmology (electrodiagnosis
Electrodiagnosis
Electrodiagnosis is a method of obtaining information about diseases by passively recording the electrical activity of body parts or by measuring their response to external electrical stimulus....

) clinics Worldwide.

Evoked potential feedback

This technique allows the SSEP to directly control the stimulus that elicits the SSEP without the conscious intervention of the experimental subject. For example, the running average of the SSEP can be arranged to increase the luminance of a checkerboard stimulus if the amplitude of the SSEP falls below some predetermined value, and to decrease luminance if it rises above this value. The amplitude of the SSEP then hovers about this predetermined value. Now the wavelength (colour) of the stimulus is progressively changed. The resulting plot of stimulus luminance versus wavelength is a plot of the spectral sensitivity of the visual system.

Visual evoked potential

In 1934, Adrian and Matthew noticed potential changes of the occipital EEG can be observed under stimulation of light. Ciganek developed the first nomenclature for occipital EEG components in 1961. During that same year, Hirsch and colleagues recorded a VEP on the occipital lobe (externally and internally), and they discovered amplitudes recorded along the calcarine fissure were the largest. In 1965, Spehlmann used a checkerboard stimulation to describe human VEPs. An attempt to localize structures in the primary visual pathway was completed by Szikla and colleagues. Halliday and colleagues completed the first clinical investigations using VEP by recording delayed VEPs in a patient with retrobulbar neuritis in 1972. A wide variety of extensive research to improve procedures and theories has been conducted from the 1970’s to today.

VEP Stimuli

The diffuse light flash stimulus is rarely used due to the high variability within and across subjects. However, it is beneficial to use this type of stimulus when testing infants or individuals with poor visual acuity. The checkerboard and grating patterns use light and dark squares and stripes, respectively. These squares and stripes are equal in size and are presented to one at a time via a television or computer screen.

VEP Electrode Placement

Electrode placement is extremely important to elicit a good VEP response free of artifact. One electrode is placed 2.5 cm above the inion and a reference electrode is placed at Fz. For a more detailed response, two additional electrodes can be placed 5 cm to the right and left of Oz.

VEP Waves

The VEP nomenclature is determined by using capital letters stating whether the peak is positive (P) or negative (N) followed by a number which indicates the average peak latency for that particular wave. For example, P50 is a wave with a positive peak at approximately 50 ms following stimulus onset.

The average amplitude for VEP waves usually falls between 5 and 10 microvolts.

Types of VEP

Some specific VEPs are:
  • Sweep visual evoked potential
  • Binocular visual evoked potential
  • Chromatic visual evoked potential
  • Hemi-field visual evoked potential
  • Flash visual evoked potential
  • LED Goggle visual evoked potential
  • Motion visual evoked potential
  • Multifocal visual evoked potential
  • Multi-channel visual evoked potential
  • Multi-frequency visual evoked potential
  • Stereo-elicited visual evoked potential

Auditory evoked potential

Auditory evoked potential can be used to trace the signal generated by a sound through the ascending auditory pathway. The evoked potential is generated in the cochlea, goes through the cochlear nerve
Cochlear nerve
The cochlear nerve is a nerve in the head that carries signals from the cochlea of the inner ear to the brain...

, through the cochlear nucleus, superior olivary complex, lateral lemniscus
Lateral lemniscus
The lateral lemniscus is a tract of axons in the brainstem that carries information about sound from the cochlear nucleus to various brainstem nuclei and ultimately the contralateral inferior colliculus of the midbrain...

, to the inferior colliculus
Inferior colliculus
The inferior colliculus is the principal midbrain nucleus of the auditory pathway and receives input from several more peripheral brainstem nuclei in the auditory pathway, as well as inputs from the auditory cortex...

 in the midbrain, on to the medial geniculate body, and finally to the cortex.

Auditory evoked potentials (AEPs) are a subclass of event-related potentials (ERP)s. ERPs are brain responses that are time-locked to some “event”, such as a sensory stimulus, a mental event (such as recognition of a target stimulus), or the omission of a stimulus. For AEPs, the “event” is a sound. AEPs (and ERPs) are very small electrical voltage potentials originating from the brain recorded from the scalp in response to an auditory stimulus, such as different tones, speech sounds, etc.

Somatosensory evoked potential

Somatosensory Evoked Potential
Somatosensory Evoked Potential
Somatosensory Evoked Potentials are a useful, noninvasive means of assessing somatosensory system functioning. By combining SEP recordings at different levels of the somatosensory pathways, it is possible to assess the transmission of the afferent volley from the periphery up to the cortex...

s (SSEPs) are used in neuromonitoring
Neuromonitoring
Intraoperative neurophysiological monitoring or intraoperative neuromonitoring is the use of electrophysiological methods such as electroencephalography , electromyography , and evoked potentials to monitor the functional integrity of certain neural structures during surgery...

 to assess the function of a patient's spinal cord
Spinal cord
The spinal cord is a long, thin, tubular bundle of nervous tissue and support cells that extends from the brain . The brain and spinal cord together make up the central nervous system...

 during surgery
Surgery
Surgery is an ancient medical specialty that uses operative manual and instrumental techniques on a patient to investigate and/or treat a pathological condition such as disease or injury, or to help improve bodily function or appearance.An act of performing surgery may be called a surgical...

. They are recorded by stimulating peripheral nerves, most commonly the tibial nerve
Tibial nerve
The tibial nerve is a branch of the sciatic nerve. The tibial nerve passes through the popliteal fossa to pass below the arch of soleus.In the popliteal fossa the nerve gives off branches to gastrocnemius, popliteus, soleus and plantaris muscles, an articular branch to the knee joint, and a...

, median nerve
Median nerve
The median nerve is a nerve in humans and other animals. It is in the upper limb. It is one of the five main nerves originating from the brachial plexus....

 or ulnar nerve
Ulnar nerve
In human anatomy, the ulnar nerve is a nerve which runs near the ulna bone. The ulnar collateral ligament of elbow joint is in relation with the ulnar nerve. The nerve is the largest unprotected nerve in the human body , so injury is common...

, typically with an electrical stimulus. The response is then recorded from the patient's scalp
Scalp
The scalp is the anatomical area bordered by the face anteriorly and the neck to the sides and posteriorly.-Layers:It is usually described as having five layers, which can conveniently be remembered as a mnemonic:...

.

Because of the low amplitude
Amplitude
Amplitude is the magnitude of change in the oscillating variable with each oscillation within an oscillating system. For example, sound waves in air are oscillations in atmospheric pressure and their amplitudes are proportional to the change in pressure during one oscillation...

 of the signal once it reaches the patient's scalp and the relatively high amount of electrical noise caused by background EEG
EEG
EEG commonly refers to electroencephalography, a measurement of the electrical activity of the brain.EEG may also refer to:* Emperor Entertainment Group, a Hong Kong-based entertainment company...

, scalp muscle EMG
Electromyography
Electromyography is a technique for evaluating and recording the electrical activity produced by skeletal muscles. EMG is performed using an instrument called an electromyograph, to produce a record called an electromyogram. An electromyograph detects the electrical potential generated by muscle...

 or electrical devices in the room, the signal must be averaged. The use of averaging improves the signal-to-noise ratio
Signal-to-noise ratio
Signal-to-noise ratio is a measure used in science and engineering that compares the level of a desired signal to the level of background noise. It is defined as the ratio of signal power to the noise power. A ratio higher than 1:1 indicates more signal than noise...

. Typically, in the operating room, over 100 and up to 1,000 averages must be used to adequately resolve the evoked potential.

The two most looked at aspects of an SSEP are the amplitude and latency of the peaks. The most predominant peaks have been studied and named in labs. Each peak is given a letter and a number in its name. For example, N20 refers to a negative peak (N) at 20ms. This peak is recorded from the cortex when the median nerve is stimulated. It most likely corresponds to the signal reaching the somatosensory cortex. When used in intraoperative monitoring, the latency and amplitude of the peak relative to the patient's post-intubation baseline is a crucial piece of information. Dramatic increases in latency or decreases in amplitude are indicators of neurological dysfunction
Dysfunction
Dysfunction can refer to:* Abnormality * Dysfunctional family* Sexual dysfunction* Dysfunction , an album by the rock band Staind...

.

During surgery, the large amounts of anesthetic gases used can affect the amplitude and latencies of SSEPs. Any of the halogenated agents or nitrous oxide
Nitrous oxide
Nitrous oxide, commonly known as laughing gas or sweet air, is a chemical compound with the formula . It is an oxide of nitrogen. At room temperature, it is a colorless non-flammable gas, with a slightly sweet odor and taste. It is used in surgery and dentistry for its anesthetic and analgesic...

 will increase latencies and decrease amplitudes of responses, sometimes to the point where a response can no longer be detected. For this reason, an anesthetic utilizing less halogenated agent and more intravenous hypnotic and narcotic is typically used.

Intraoperative monitoring

Somatosensory evoked potentials provide monitoring for the dorsal columns of the spinal cord. Sensory evoked potentials may also be used during surgeries which place brain structures at risk. They are effectively used to determine cortical ischemia during carotid endarterectomy surgeries and for mapping the sensory areas of the brain during brain surgery.

Electrical stimulation of the scalp can produce an electrical current within the brain that activates the motor pathways of the pyramidal tracts. This technique is known as transcranial electrical motor potential (TcMEP) monitoring. This technique effectively evaluates the motor pathways in the central nervous system during surgeries which place these structures at risk. These motor pathways, including the lateral corticospinal tract, are located in the lateral and ventral funiculi of the spinal cord. Since the ventral and dorsal spinal cord have separate blood supply with very limited collateral flow, an anterior cord syndrome (paralysis or paresis with some preserved sensory function) is a possible surgical sequela, so it is important to have monitoring specific to the motor tracts as well as dorsal column monitoring.

Transcranial magnetic stimulation versus electrical stimulation is generally regarded as unsuitable for intraoperative monitoring because it is more sensitive to anesthesia. Electrical stimulation is too painful for clinical use in awake patients. The two modalities are thus complementary, electrical stimulation being the choice for intraoperative monitoring, and magnetic for clinical applications.

Motor evoked potentials

Motor evoked potentials (MEP) are recorded from muscles following direct stimulation of exposed motor cortex, or transcranial stimulation of motor cortex, either magnetic
Transcranial magnetic stimulation
Transcranial magnetic stimulation is a noninvasive method to cause depolarization or hyperpolarization in the neurons of the brain...

 or electrical. Transcranial magnetic MEP (TCmMEP) potentially offer clinical diagnostic applications. Transcranial electrical MEP (TCeMEP) has been in widespread use for several years for intraoperative monitoring of pyramidal tract functional integrity.

During the 1990s there were attempts to monitor "motor evoked potentials", including "neurogenic motor evoked potentials" recorded from peripheral nerves, following direct electrical stimulation of the spinal cord. It has become clear that these "motor" potentials were almost entirely elicited by antidromic stimulation of sensory tracts—even when the recording was from muscles (antidromic sensory tract stimulation triggers myogenic responses through synapses at the root entry level). TCMEP, whether electrical or magnetic, is the most practical way to ensure pure motor responses, since stimulation of sensory cortex cannot result in descending impulses beyond the first synapse (synapses cannot be backfired).

TMS
Transcranial magnetic stimulation
Transcranial magnetic stimulation is a noninvasive method to cause depolarization or hyperpolarization in the neurons of the brain...

-induced MEPs have been used in many experiments in cognitive neuroscience
Cognitive neuroscience
Cognitive neuroscience is an academic field concerned with the scientific study of biological substrates underlying cognition, with a specific focus on the neural substrates of mental processes. It addresses the questions of how psychological/cognitive functions are produced by the brain...

. Because MEP amplitude is correlated with motor excitability, they offer a way to quantitativeley test the role of various types of intervention on the motor system (pharmacological, behavioral, lesion...) TMS-induced MEPs may thus serve as a index of covert motor preparation
Premovement neuronal activity
Premovement neuronal activity in neurophysiological literature refers to neuronal modulations that alter the rate at which neurons fire before a subject produces movement. Through experimentation with multiple animals, predominantly monkeys, it has been shown that several regions of the brain are...

 or facilitation, e.g., induced by the mirror neuron
Mirror neuron
A mirror neuron is a neuron that fires both when an animal acts and when the animal observes the same action performed by another. Thus, the neuron "mirrors" the behaviour of the other, as though the observer were itself acting. Such neurons have been directly observed in primate and other...

 system when seeing someone's else actions. In addition, MEPs are used as a reference to adjust the intensity of stimulation that need to delivered by TMS when targetting cortical regions whose response might not be as easily measurable, e.g., in the context of TMS-based therapy.

See also

  • Event-related potential
    Event-related potential
    An event-related potential is any measured brain response that is directly the result of a thought or perception. More formally, it is any stereotyped electrophysiological response to an internal or external stimulus....

  • Evoked field
    Evoked field
    Evoked fields are part of the magnetoencephalogram. They are brain signals evoked by sensory stimulation, but usually buried by the ongoing brain activity...

  • Neural oscillation
  • Electroencephalography
    Electroencephalography
    Electroencephalography is the recording of electrical activity along the scalp. EEG measures voltage fluctuations resulting from ionic current flows within the neurons of the brain...

  • Electroretinography
    Electroretinography
    Electroretinography measures the electrical responses of various cell types in the retina, including the photoreceptors , inner retinal cells , and the ganglion cells. Electrodes are usually placed on the cornea and the skin near the eye, although it is possible to record the ERG from skin electrodes...

  • International Society for Clinical Electrophysiology of Vision
    International Society for Clinical Electrophysiology of Vision
    The International Society for Clinical Electrophysiology of Vision is an association that promotes research and applications of electrophysiological methods in clinical diagnosis of ophthalmological diseases...

  • Somatosensory evoked potential
    Somatosensory Evoked Potential
    Somatosensory Evoked Potentials are a useful, noninvasive means of assessing somatosensory system functioning. By combining SEP recordings at different levels of the somatosensory pathways, it is possible to assess the transmission of the afferent volley from the periphery up to the cortex...

  • C1 and P1
    C1 & P1 (Neuroscience)
    The C1 and P1 are two human scalp-recorded event-related brain potential components, collected by means of a technique called electroencephalography . The C1 is named so because it was the first component in a series of components found to respond to visual stimuli when it was first discovered...

  • Visual N1
    Visual N1
    The Visual N1 is a visual evoked potential, a type of event-related electrical potential , that is produced in the brain and recorded on the scalp. The N1 is so named to reflect the polarity and typical timing of the component. The "N" indicates that the polarity of the component is negative with...

  • Mismatch negativity
    Mismatch negativity
    The mismatch negativity or mismatch field is a component of the event-related potential to an odd stimulus in a sequence of stimuli. It arises from electrical activity in the brain and is studied within the field of cognitive neuroscience and psychology. It can occur in any sensory system, but...

  • N100
  • N200
    N200 (neuroscience)
    The N200, or N2, is an event-related potential component. An ERP can be monitored using a non-invasive electroencephalography cap that is fitted over the scalp on human subjects...

  • N2pc
    N2pc
    N2pc refers to an ERP component linked to selective attention. The N2pc appears over visual cortex contralateral to the location in space to which subjects are attending; if subjects pay attention to the left side of the visual field, the N2pc appears in the right hemisphere of the brain, and...

  • N170
    N170
    The N170 is a component of the event-related potential that reflects the neural processing of faces.When potentials evoked by images of faces are compared to those elicited by other visual stimuli, the former show increased negativity 130-200 ms after stimulus presentation...

  • P200
    P200
    In neuroscience, the visual P200 or P2 is a waveform component or feature of the event-related potential measured at the human scalp. Like other potential changes measurable from the scalp, this effect is believed to reflect the post-synaptic activity of a specific neural process...

  • N400
  • P300 (neuroscience)
    P300 (neuroscience)
    The P300 wave is an event related potential elicited by infrequent, task-relevant stimuli. It is considered to be an endogenous potential as its occurrence links not to the physical attributes of a stimulus but to a person's reaction to the stimulus. More specifically, the P300 is thought to...

  • P3a
    P3a
    The P3a, or novelty P3, is a component of time-locked signals known as event-related potentials . The P3a is a positive-going scalp-recorded brain potential that has a maximum amplitude over frontal/central electrode sites with a peak latency falling in the range of 250-280 ms...

  • P3b
    P3b
    The P3b is a subcomponent of the P300, an event-related potential component that can be observed in human scalp recordings of brain electrical activity...

  • Late Positive Component
    Late Positive Component
    The LPC is a positive-going event-related brain potential component that has been important in studies of explicit recognition memory...

  • Difference due to Memory
    Difference due to Memory
    Difference due to Memory indexes differences in neural activity during the study phase of an experiment for items that subsequently are remembered compared to items that are later forgotten...

  • Contingent negative variation
    Contingent negative variation
    The contingent negative variation was one of the first event-related potential components to be described. The CNV component was first described by Dr. W. Grey Walter and colleagues in an article published in Nature in 1964...

  • Error-related negativity
    Error-related negativity
    Error-related negativity , , is a component of an event-related potential . ERPs are electrical activity in the brain as measured through electroencephalography and time-locked to an external event...

  • Bereitschaftspotential
    Bereitschaftspotential
    In neurology, the Bereitschaftspotential or BP , also called the pre-motor potential or readiness potential , is a measure of activity in the motor cortex of the brain leading up to voluntary muscle movement. The BP is a manifestation of cortical contribution to the pre-motor planning of volitional...

  • Lateralized readiness potential
    Lateralized readiness potential
    In neuroscience, the lateralized readiness potential is an event-related brain potential, or increase in electrical activity at the surface of the brain, that is thought to reflect the preparation of motor activity on a certain side of the body; in other words, it is a spike in the electrical...

  • Early left anterior negativity
    Early left anterior negativity
    The early left anterior negativity is an event-related potential in electroencephalography , or component of brain activity that occurs in response to a certain kind of stimulus...

  • P600
    P600
    The P600 is an event-related potential , or peak in electrical brain activity measured by electroencephalography . It is a language-relevant ERP and is thought to be elicited by hearing or reading grammatical errors and other syntactic anomalies...

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