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Ernest William Goodpasture

 

 
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Ernest William Goodpasture
 
 
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Dr. Ernest William Goodpasture (October 17, 1886 – September 20, 1960) was an American
United States

The United States of America is a Federal government constitutional republic comprising U.S. state and a federal district. The country is situated mostly in central North America, where its Contiguous United States and Washington, D.C., the Capital districts and territories, lie between the Pacific Ocean and Atlantic Oceans, Borders of the U...
 pathologist and physician
Physician

A physician, medical practitioner, doctor of medicine, or medical doctor practices medicine, and is concerned with maintaining or restoring human health through the study, diagnosis, and treatment of disease and injury....
. Goodpasture advanced the scientific understanding of the pathogenesis of infectious diseases, parasitism, and a variety of rickettsia
Rickettsia

Rickettsia is a genus of Motility, Gram-negative, Endospore, highly pleomorphic Bacterium that can present as cocci , rods or thread-like ....
l and viral
Virus

A virus is a Optical microscope#Limitations of light microscopes infectious agent that is unable to grow or reproduce outside a host cell . Viruses infect all cellular life....
 infections. Together with colleagues at Vanderbilt University
Vanderbilt University

Vanderbilt University is a private university research university in Nashville, Tennessee, Tennessee, United States. Founded in 1873, the university is named for ship transport and rail transport magnate Cornelius Vanderbilt, who provided Vanderbilt its initial United States dollar1 million endowment despite having never been to the Southern...
, he invented methods for growing viruses and rickettsiae in chicken
Chicken

The chicken is a Domestication fowl. Recent evidence suggests that domestication of the chicken was under way in Vietnam over 10,000 years ago....
 embryos and fertilized chicken eggs
Egg (biology)

In most birds and reptiles, an egg is the zygote, resulting from fertilization of the ovum. To enable incubation the egg is usually kept within a favourable temperature range as it nourishes and protects the growing embryo....
. This enabled the development of vaccines against chicken pox, smallpox
Smallpox

Smallpox is an infectious disease unique to humans, caused by either of two virus variants, Variola major and Variola minor. The disease is also known by the Latin names Variola or Variola vera, which is a derivative of the Latin varius, meaning spotted, or varus, meaning "pimple"....
, yellow fever
Yellow fever

Yellow fever is an acute Virus disease. It is an important cause of hemorrhage illness in many African and South American countries despite existence of an effective vaccine....
, typhus
Typhus

Epidemic typhus is a form of typhus so named because the disease often causes epidemics following wars and natural disasters. The causative organism is Rickettsia prowazekii, transmitted by the human body louse ....
, Rocky mountain spotted fever
Rocky Mountain spotted fever

Rocky Mountain spotted fever is the most lethal and most frequently reported rickettsial illness in the United States. It has been diagnosed throughout the Americas....
 and other diseases.






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Dr. Ernest William Goodpasture (October 17, 1886 – September 20, 1960) was an American
United States

The United States of America is a Federal government constitutional republic comprising U.S. state and a federal district. The country is situated mostly in central North America, where its Contiguous United States and Washington, D.C., the Capital districts and territories, lie between the Pacific Ocean and Atlantic Oceans, Borders of the U...
 pathologist and physician
Physician

A physician, medical practitioner, doctor of medicine, or medical doctor practices medicine, and is concerned with maintaining or restoring human health through the study, diagnosis, and treatment of disease and injury....
. Goodpasture advanced the scientific understanding of the pathogenesis of infectious diseases, parasitism, and a variety of rickettsia
Rickettsia

Rickettsia is a genus of Motility, Gram-negative, Endospore, highly pleomorphic Bacterium that can present as cocci , rods or thread-like ....
l and viral
Virus

A virus is a Optical microscope#Limitations of light microscopes infectious agent that is unable to grow or reproduce outside a host cell . Viruses infect all cellular life....
 infections. Together with colleagues at Vanderbilt University
Vanderbilt University

Vanderbilt University is a private university research university in Nashville, Tennessee, Tennessee, United States. Founded in 1873, the university is named for ship transport and rail transport magnate Cornelius Vanderbilt, who provided Vanderbilt its initial United States dollar1 million endowment despite having never been to the Southern...
, he invented methods for growing viruses and rickettsiae in chicken
Chicken

The chicken is a Domestication fowl. Recent evidence suggests that domestication of the chicken was under way in Vietnam over 10,000 years ago....
 embryos and fertilized chicken eggs
Egg (biology)

In most birds and reptiles, an egg is the zygote, resulting from fertilization of the ovum. To enable incubation the egg is usually kept within a favourable temperature range as it nourishes and protects the growing embryo....
. This enabled the development of vaccines against chicken pox, smallpox
Smallpox

Smallpox is an infectious disease unique to humans, caused by either of two virus variants, Variola major and Variola minor. The disease is also known by the Latin names Variola or Variola vera, which is a derivative of the Latin varius, meaning spotted, or varus, meaning "pimple"....
, yellow fever
Yellow fever

Yellow fever is an acute Virus disease. It is an important cause of hemorrhage illness in many African and South American countries despite existence of an effective vaccine....
, typhus
Typhus

Epidemic typhus is a form of typhus so named because the disease often causes epidemics following wars and natural disasters. The causative organism is Rickettsia prowazekii, transmitted by the human body louse ....
, Rocky mountain spotted fever
Rocky Mountain spotted fever

Rocky Mountain spotted fever is the most lethal and most frequently reported rickettsial illness in the United States. It has been diagnosed throughout the Americas....
 and other diseases. He also described Goodpasture's syndrome
Goodpasture's syndrome

Goodpasture?s syndrome is a rare condition characterised by rapid destruction of the kidneys and haemorrhaging of the lungs. Although many diseases can present with these symptoms, the name Goodpasture?s syndrome is usually reserved for the autoimmune disease produced when the patient?s immune system attacks cells presenting the Goodpasture...
, which bears his name, despite the fact that the case that was described by Goodpasture was presented as a case of influenza and probably did not have anti-GBM disease.

Biography

Goodpasture received his B.A. from Vanderbilt University. In 1912, Goodpasture graduated from Johns Hopkins Medical School
Johns Hopkins University

The Johns Hopkins University, commonly referred to as Hopkins or JHU, is a private university research university located in Baltimore, Maryland, Maryland, United States....
 and received his doctorate. It was there, under professors William Welch and George H. Whipple, that he was appointed a Rockefeller Fellow in pathology
Pathology

Pathology is the study and diagnosis of disease through examination of Organ , tissue , bodily fluids and whole bodies . The term also encompasses the related science study of disease processes, called General pathology....
; he held this position from 1912-1914. He held positions in pathology at Johns Hopkins until 1915. In 1915 he became part of the faculty of Harvard Medical School
Harvard Medical School

Harvard Medical School is one of the graduate schools of Harvard University and currently the #1 medical school in America, as ranked by U.S. News and World Report....
. In 1915 he also became the resident pathologist
Residency (medicine)

Residency is a stage of graduate Medical education. A resident physician or resident is a person who has received a medical degree and who practices medicine under the supervision of fully licensed physicians, usually in a hospital or clinic....
 at the Penter Bent Brigham Hospital
Brigham and Women's Hospital

Brigham and Women's Hospital is the largest hospital of Longwood Medical and Academic Area, Boston, Massachusetts and is directly adjacent to Harvard Medical School of which it is the second largest Teaching hospital....
 in Boston, and held the position until 1917. From 1917-1921 he was the assistant professor of pathology at Harvard Medical School. During this period, he also served two years of wartime service in the United States Navy
United States Navy

The United States Navy is the navy of the United States Armed Forces. It is one of the seven uniformed services of the United States. The U.S. Navy currently has approximately 331,682 personnel on active duty as of 31 December 2008 and 124,000 in the United States Navy Reserve....
. This period was followed by appointments at the University of the Philippines School of Medicine in Manila. From 1922-1924 he was the director of William H. Singer Memorial Laboratories in Pittsburgh, Pennsylvania
Pittsburgh, Pennsylvania

Pittsburgh is the second largest city in the U.S. state of Pennsylvania with a population of 312,819. The population of the seven-county metropolitan area is 2,462,571....
. In 1924 he was invited to return to Vanderbilt as a professor, and chairman of the Department of Pathology (the School of Medicine having been recently reorganized). He accepted, and held the position until 1955.

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