EIF2B
Encyclopedia
eIF2B is a protein
found in eukaryote
s. It is the guanine nucleotide exchange factor
for the eukaryotic initiation factor 2 and therefore converts the inactive eIF2-GDP to the active eIF2-GTP. This activation is hindered by phosphorylation of the alpha subunit of eIF2 and therefore inhibits translation initiation.
Human genes which encode eIF-2B proteins include:
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
found in eukaryote
Eukaryote
A eukaryote is an organism whose cells contain complex structures enclosed within membranes. Eukaryotes may more formally be referred to as the taxon Eukarya or Eukaryota. The defining membrane-bound structure that sets eukaryotic cells apart from prokaryotic cells is the nucleus, or nuclear...
s. It is the guanine nucleotide exchange factor
Guanine nucleotide exchange factor
Guanine nucleotide exchange factors activate monomeric GTPases by stimulating the release of guanosine diphosphate to allow binding of guanosine triphosphate . A variety of unrelated structural domains have been shown to exhibit guanine nucleotide exchange activity...
for the eukaryotic initiation factor 2 and therefore converts the inactive eIF2-GDP to the active eIF2-GTP. This activation is hindered by phosphorylation of the alpha subunit of eIF2 and therefore inhibits translation initiation.
Human genes which encode eIF-2B proteins include:
- EIF2B1EIF2B1Translation initiation factor eIF-2B subunit alpha is a protein that in humans is encoded by the EIF2B1 gene.-Further reading:...
– alpha subunit - EIF2B2EIF2B2Translation initiation factor eIF-2B subunit beta is a protein that in humans is encoded by the EIF2B2 gene.-Interactions:EIF2B2 has been shown to interact with EIF2B5 and NCK1.-Further reading:...
– beta subunit - EIF2B3EIF2B3Translation initiation factor eIF-2B subunit gamma is a protein that in humans is encoded by the EIF2B3 gene.-Further reading:...
– gamma subunit - EIF2B4EIF2B4Translation initiation factor eIF-2B subunit delta is a protein that in humans is encoded by the EIF2B4 gene.-Further reading:...
– delta subunit - EIF2B5EIF2B5Translation initiation factor eIF-2B subunit epsilon is a protein that in humans is encoded by the EIF2B5 gene.-Interactions:EIF2B5 has been shown to interact with EIF2B2 and EIF2B1.-Further reading:...
– epsilon subunit