Doi's sign
Encyclopedia
Doi's sign is a clinical sign
Medical sign
A medical sign is an objective indication of some medical fact or characteristic that may be detected by a physician during a physical examination of a patient....

 in which absent deep tendon reflexes
Reflex
A reflex action, also known as a reflex, is an involuntary and nearly instantaneous movement in response to a stimulus. A true reflex is a behavior which is mediated via the reflex arc; this does not apply to casual uses of the term 'reflex'.-See also:...

 can be elicited after a short period of maximal muscle contraction
Muscle contraction
Muscle fiber generates tension through the action of actin and myosin cross-bridge cycling. While under tension, the muscle may lengthen, shorten, or remain the same...

. This occurs in patients with Eaton-Lambert syndrome, but is not seen in patients with neuropathy.

The sign is named after Dr. Hitoka M.D.
Doctor of Medicine
Doctor of Medicine is a doctoral degree for physicians. The degree is granted by medical schools...

, who described it in 1978.
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