Dimethylthiambutene
Encyclopedia
Dimethylthiambutene is an opioid
Opioid
An opioid is a psychoactive chemical that works by binding to opioid receptors, which are found principally in the central and peripheral nervous system and the gastrointestinal tract...

 analgesic
Analgesic
An analgesic is any member of the group of drugs used to relieve pain . The word analgesic derives from Greek an- and algos ....

 drug, most often used in veterinary medicine in Japan and to a lesser extent in other countries in the region and around the world. It is the most prominent and widely-used of the thiambutenes, a series of open-chain opioids structurally related to methadone
Methadone
Methadone is a synthetic opioid, used medically as an analgesic and a maintenance anti-addictive for use in patients with opioid dependency. It was developed in Germany in 1937...

 which are also called the thienyl derivative opioids which also includes diethylthiambutene
Diethylthiambutene
Diethylthiambutene is an opioid analgesic drug developed in the 1950s which was mainly used as an anesthetic in veterinary medicine and continues, along with the other two thiambutenes dimethylthiambutene and ethylmethylthiambutene to be used for this purpose, particularly in Japan...

 and ethylmethylthiambutene
Ethylmethylthiambutene
Ethylmethylthiambutene is an opioid analgesic drug from the thiambutene family, around 1.3x the potency of morphine. It is under international control under Schedule I of the UN Single Convention On Narcotic Drugs 1961, presumably due to high abuse potential....

 as well as the cough suppressant tipepidine
Tipepidine
Tipepidine was discovered in the 1950s. Under the trade-names is used as a centrally-acting cough suppressant of the opioid type...

, which is weaker and not a controlled substance in most of the world.

Dimethylthiambutene was developed in the United States in the early 1950s and introduced to the market by Burroughs-Wellcome in the United Kingdom in 1951. Dimethylthiambutene is now under international control under the UN Single Convention on Narcotic Drugs
Single Convention on Narcotic Drugs
The Single Convention on Narcotic Drugs of 1961 is an international treaty to prohibit production and supply of specific drugs and of drugs with similar effects except under licence for specific purposes, such as medical treatment and research...

 1961, the laws governing habit-forming substances in virtually all countries and Schedule I of the US Controlled Substances Act of 1970 due to high abuse potential and never being introduced clinically in the United States; other countries regulate it much as morphine
Morphine
Morphine is a potent opiate analgesic medication and is considered to be the prototypical opioid. It was first isolated in 1804 by Friedrich Sertürner, first distributed by same in 1817, and first commercially sold by Merck in 1827, which at the time was a single small chemists' shop. It was more...

 or diamorphine.
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