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Daidzein

 

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Daidzein



 
 
Daidzein is one of several known isoflavone
Isoflavone

Isoflavones comprise a class of organic compounds, often naturally occurring, related to the flavonoids. Many act as phytoestrogens in mammals. Being polyphenols, they are antioxidants....
s. Isoflavones compounds, such as daidzein and genistein
Genistein

Genistein is one of several known isoflavones. Isoflavones, such as genistein and daidzein, are found in a number of plants, with soybeans and soy products like tofu and textured vegetable protein being the primary food source....
, are found in a number of plant
Plant

Plants are Life organisms belonging to the Kingdom Plantae. They include familiar organisms such as trees, herbs, bushes, grasses, vines, ferns, mosses, and green algae....
s and herbs like the Thai Kwao Krua or Pueraria Mirifica, but soybean
Soybean

The soybean or soya bean is a species of legume native to East Asia. The plant is classed as an oilseed rather than a Pulse . It is an annual plant that has been used in China for 5,000 years as a food and a component of drugs....
s and soy products like tofu
Tofu

Tofu , also , doufu , toufu, or bean curd , is a food of China origin, made by coagulating soy milk, and then pressing the resulting curds into blocks....
 and textured vegetable protein
Textured vegetable protein

Textured or texturized vegetable protein , also known as textured soy protein is a meat analogue or meat substitute made from defatted soy flour, a by-product of making soybean oil....
 are the primary food source. Soy isoflavones are a group of compounds found in and isolated from the soybean. Besides functioning as antioxidant
Antioxidant

An antioxidant is a molecule capable of slowing or preventing the Redox of other molecules. Oxidation is a chemical reaction that transfers electrons from a substance to an oxidizing agent....
s, many isoflavones have been shown to interact with animal
Animal

Animals are a major group of multicellular, eukaryotic organisms of the Kingdom Animalia or Metazoa. Their body plan eventually becomes fixed as they develop, although some undergo a process of metamorphosis later on in their life....
 and human
Human

A human being, also human or man, is a member of a species of bipedalism primates in the family Hominidae . Mitochondrial DNA evidence indicates that modern humans originated in east Africa about 200,000 years ago....
 estrogen receptor
Estrogen receptor

Estrogen receptor refers to a group of receptor s which are activated by the hormone estrogen . Two types of estrogen receptor exist: ER which is a member of the nuclear receptor family of intracellular receptors and the estrogen G protein coupled receptor GPR30 , which is a G-protein coupled receptor....
s, and are therefore known as phytoestrogens
Phytoestrogens

Phytoestrogens, sometimes called "dietary estrogens", are a diverse group of naturally occurring non steroidal plant compounds that, because of their structural similarity with estradiol , have the ability to cause estrogenic or/and antiestrogenic effects....
.






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Encyclopedia


Daidzein is one of several known isoflavone
Isoflavone

Isoflavones comprise a class of organic compounds, often naturally occurring, related to the flavonoids. Many act as phytoestrogens in mammals. Being polyphenols, they are antioxidants....
s. Isoflavones compounds, such as daidzein and genistein
Genistein

Genistein is one of several known isoflavones. Isoflavones, such as genistein and daidzein, are found in a number of plants, with soybeans and soy products like tofu and textured vegetable protein being the primary food source....
, are found in a number of plant
Plant

Plants are Life organisms belonging to the Kingdom Plantae. They include familiar organisms such as trees, herbs, bushes, grasses, vines, ferns, mosses, and green algae....
s and herbs like the Thai Kwao Krua or Pueraria Mirifica, but soybean
Soybean

The soybean or soya bean is a species of legume native to East Asia. The plant is classed as an oilseed rather than a Pulse . It is an annual plant that has been used in China for 5,000 years as a food and a component of drugs....
s and soy products like tofu
Tofu

Tofu , also , doufu , toufu, or bean curd , is a food of China origin, made by coagulating soy milk, and then pressing the resulting curds into blocks....
 and textured vegetable protein
Textured vegetable protein

Textured or texturized vegetable protein , also known as textured soy protein is a meat analogue or meat substitute made from defatted soy flour, a by-product of making soybean oil....
 are the primary food source. Soy isoflavones are a group of compounds found in and isolated from the soybean. Besides functioning as antioxidant
Antioxidant

An antioxidant is a molecule capable of slowing or preventing the Redox of other molecules. Oxidation is a chemical reaction that transfers electrons from a substance to an oxidizing agent....
s, many isoflavones have been shown to interact with animal
Animal

Animals are a major group of multicellular, eukaryotic organisms of the Kingdom Animalia or Metazoa. Their body plan eventually becomes fixed as they develop, although some undergo a process of metamorphosis later on in their life....
 and human
Human

A human being, also human or man, is a member of a species of bipedalism primates in the family Hominidae . Mitochondrial DNA evidence indicates that modern humans originated in east Africa about 200,000 years ago....
 estrogen receptor
Estrogen receptor

Estrogen receptor refers to a group of receptor s which are activated by the hormone estrogen . Two types of estrogen receptor exist: ER which is a member of the nuclear receptor family of intracellular receptors and the estrogen G protein coupled receptor GPR30 , which is a G-protein coupled receptor....
s, and are therefore known as phytoestrogens
Phytoestrogens

Phytoestrogens, sometimes called "dietary estrogens", are a diverse group of naturally occurring non steroidal plant compounds that, because of their structural similarity with estradiol , have the ability to cause estrogenic or/and antiestrogenic effects....
. Soy isoflavones also produce non-hormonal effects.

Isoflavones act as antioxidants to counteract damaging effects of free radicals in tissues. Isoflavones can act like estrogen in stimulating development and maintenance of female characteristics or they can block cells from using other forms of estrogen. Isoflavones also have been found to have antiangiogenic effects (blocking formation of new blood vessels), and may block the uncontrolled cell growth associated with cancer, most likely by inhibiting the activity of substances in the body that regulate cell division and cell survival (growth factors).

Studies show that groups of people who eat large amounts of soy-based products have lower incidences of breast, colon, endometrial, and prostate cancers than the general (US) population. Initial studies of soy and Kwao Krua isoflavone mixtures containing genistein, daidzein, and glycitein have found them safe for human use. Laboratory studies using animals models have shown that both soy and isoflavones can be protective against cancer when given during early life but can stimulate response to cancer-causing chemicals when given during fetal development or when circulating levels of estrogen are low (menopause).

Pueraria mirifica
Pueraria mirifica

Pueraria mirifica is a root found in northern and north eastern Thailand and Myanmar.In Thailand, the plant ?Kwao Krua? is considered to be a rejuvenating adaptogenic herb and has a history in folk medicine....
 or White Kawo Krua has been found to contain concentrations of daidzein where the CuČ+ at 300 ppm is shown to contain as much as 44.69 ppm of daidzein. Another source of daidzein is Kudzu also known as Pueraria Lobata.

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