DEA list of chemicals
Encyclopedia
The United States
Drug Enforcement Administration
(DEA) maintains lists regarding not only the classification of illicit drugs (see DEA Schedules). It also maintains List I of chemicals and List II of chemicals, which contain chemicals which are used to manufacture the controlled substances/illicit drugs. The lists are designated within The Controlled Substances Act
, , Definition 34 (list I) and 35 (list II).
Although the list is designated by the U.S. Attorney General, the list is considered a DEA list because the DEA publishes and enforces the list.
Suppliers of these products are subject to regulation and control measures.
All listed chemicals as specified in 21 CFR 1310.02 (a) or (b). This includes all chemical mixtures and all over-the-counter (OTC) products and dietary supplements which contain a listed chemical, regardless of their dosage form or packaging and regardless of whether the chemical mixture, drug product or dietary supplement is exempt from regulatory controls.
Equipment
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
Drug Enforcement Administration
Drug Enforcement Administration
The Drug Enforcement Administration is a federal law enforcement agency under the United States Department of Justice, tasked with combating drug smuggling and use within the United States...
(DEA) maintains lists regarding not only the classification of illicit drugs (see DEA Schedules). It also maintains List I of chemicals and List II of chemicals, which contain chemicals which are used to manufacture the controlled substances/illicit drugs. The lists are designated within The Controlled Substances Act
Controlled Substances Act
The Controlled Substances Act was enacted into law by the Congress of the United States as Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970. The CSA is the federal U.S. drug policy under which the manufacture, importation, possession, use and distribution of certain...
, , Definition 34 (list I) and 35 (list II).
Although the list is designated by the U.S. Attorney General, the list is considered a DEA list because the DEA publishes and enforces the list.
Suppliers of these products are subject to regulation and control measures.
List I chemicals
These chemicals are designated as those that are used in the manufacture of the controlled substances and are important to the manufacture of the substances.- anthranilic acidAnthranilic acidAnthranilic acid is the organic compound with the formula C6H4COOH. This amino acid is a white solid when pure, although commercial samples may appear yellow. The molecule consists of a benzene ring with two adjacent functional groups, a carboxylic acid and an amine...
, its esterEsterEsters are chemical compounds derived by reacting an oxoacid with a hydroxyl compound such as an alcohol or phenol. Esters are usually derived from an inorganic acid or organic acid in which at least one -OH group is replaced by an -O-alkyl group, and most commonly from carboxylic acids and...
s, and its saltSaltIn chemistry, salts are ionic compounds that result from the neutralization reaction of an acid and a base. They are composed of cations and anions so that the product is electrically neutral...
s - benzyl cyanideBenzyl cyanideBenzyl cyanide is an organic compound with the chemical formula C6H5CH2CN. This colorless oily aromatic liquid is a precursor to several derivatives.-Synthesis, reactions, and applications:...
- ephedrineEphedrineEphedrine is a sympathomimetic amine commonly used as a stimulant, appetite suppressant, concentration aid, decongestant, and to treat hypotension associated with anaesthesia....
its salts, optical isomers, and salts of optical isomers - ergocristineErgocristineErgocristine is an ergopeptine and one of the ergot alkaloids.It was used as precursor in the manufacture of LSD as an alternative for the controlled substances ergotamine and ergometrine by various LSD manufacturers, including William Leonard Pickard...
and its salts - ergonovineErgonovineErgometrine , is an ergoline derivative, and one of the primary ergot and morning glory alkaloids...
and its salts - ergotamine and its salts
- hydroiodic acid
- hypophosphorous acidHypophosphorous acidHypophosphorous acid is a phosphorus oxoacid and a powerful reducing agent with molecular formula H3PO2. Inorganic chemists refer to the free acid by this name , or the acceptable name of phosphinic acid. It is a colorless low-melting compound, which is soluble in water, dioxane, and alcohols...
and its salts (including ammonium hypophosphite, calcium hypophosphite, iron hypophosphite, potassium hypophosphite, manganese hypophosphite, magnesium hypophosphite and sodium hypophosphiteSodium hypophosphiteSodium hypophosphite is the sodium salt of hypophosphorous acid and is often encountered as the monohydrate, NaPO2H2·H2O. It is a solid at room temperature, appearing as odorless white crystals...
) - IodineIodineIodine is a chemical element with the symbol I and atomic number 53. The name is pronounced , , or . The name is from the , meaning violet or purple, due to the color of elemental iodine vapor....
, including elemental iodine crystals and chemical mixtures containing greater than 2.2% concentration of iodine (e.g., strong iodine tincture and Lugol's iodineLugol's iodineLugol's iodine, also known as Lugol's solution, first made in 1829, is a solution of elemental iodine and potassium iodide in water, named after the French physician J.G.A. Lugol. Lugol's iodine solution is often used as an antiseptic and disinfectant, for emergency disinfection of drinking water,...
) - N-acetylanthranilic acidN-acetylanthranilic acidN-Acetylanthranilic acid is an organic compound with the molecular formula C9H9NO3. It is an intermediate product in catabolism of quinaldine in Arthrobacter sp., and is further metabolized to anthranilic acid....
, its esters, and its salts - norpseudoephedrine, its salts, optical isomers, and salts of optical isomers
- phenylacetic acidPhenylacetic acidPhenylacetic acid is an organic compound containing a phenyl functional group and a carboxylic acid functional group. It is a white solid with a disagreeable odor...
, its esters, and its salts - phenylacetonePhenylacetonePhenylacetone , is an organic compound. It is a clear oil with a refractive index of 1.5168. This substance is used in the manufacture of methamphetamine and amphetamine as a starting material or intermediate, where it is commonly known as P2P...
- phenylpropanolaminePhenylpropanolaminePhenylpropanolamine , also known as the stereoisomers norephedrine and norpseudoephedrine, is a psychoactive drug of the phenethylamine and amphetamine chemical classes which is used as a stimulant, decongestant, and anorectic agent. It is commonly used in prescription and over-the-counter cough...
, its salts, optical isomers, and salts of optical isomers - phosphorusPhosphorusPhosphorus is the chemical element that has the symbol P and atomic number 15. A multivalent nonmetal of the nitrogen group, phosphorus as a mineral is almost always present in its maximally oxidized state, as inorganic phosphate rocks...
(white or red allotropes) - piperidinePiperidinePiperidine is an organic compound with the molecular formula 5NH. This heterocyclic amine consists of a six-membered ring containing five methylene units and one nitrogen atom...
and its salts - pseudoephedrinePseudoephedrinePseudoephedrine is a sympathomimetic drug of the phenethylamine and amphetamine chemical classes. It is used as a nasal/sinus decongestant and stimulant, or as a wakefulness-promoting agent....
, its salts, optical isomers, and salts of optical isomers - 3,4-methylenedioxyphenyl-2-propanone
- benzaldehydeBenzaldehydeBenzaldehyde is an organic compound consisting of a benzene ring with a formyl substituent. It is the simplest aromatic aldehyde and one of the most industrially useful. This colorless liquid has a characteristic pleasant almond-like odor...
- nitroethaneNitroethaneNitroethane is an organic compound having the chemical formula C2H5NO2. Similar in many regards to nitromethane, nitroethane is an oily liquid at standard temperature and pressure. Pure nitroethane is colourless and has a fruity odor.- Preparation :...
- gamma butyrolactone
- N-Phenethyl-4-piperidinoneN-Phenethyl-4-piperidinoneN-Phenethyl-4-piperidinone is a derivative of 4-piperidinone with the molecular formula C13H17NO. 4-Piperidone is used as an intermediate in the manufacture of chemicals and pharmaceutical drugs such as fentanyl....
- the following chemicals or the salt, optical isomer, or salt of an optical isomer of the following chemicals
- methylamineMethylamineMethylamine is the organic compound with a formula of CH3NH2. This colourless gas is a derivative of ammonia, but with one H atom replaced by a methyl group. It is the simplest primary amine. It is sold as a solution in methanol, ethanol, THF, and water, or as the anhydrous gas in pressurized...
- ethylamineEthylamineEthylamine is an organic compound with the formula CH3CH2NH2. This colourless gas has a strong ammonia-like odor. It is miscible with virtually all solvents and is considered to be a weak base, as is typical for amines. Ethylamine is widely used in chemical industry and organic...
- propionic anhydride
- isosafroleIsosafroleIsosafrole is a phenylpropene, a type of aromatic organic chemical with a smell similar to anise or licorice. It is found in small amounts in various essential oils, but is most commonly obtained by isomerizing the plant oil safrole....
- safroleSafroleSafrole, also known as shikimol, is a phenylpropene. It is a colorless or slightly yellow oily liquid. It is typically extracted from the root-bark or the fruit of sassafras plants in the form of sassafras oil , or synthesized from other related methylenedioxy...
- piperonalPiperonalPiperonal, also known as heliotropin, is an aromatic aldehyde that comes as transparent crystals, C8H6O3, and has a floral odor commonly described as being similar to that of vanillin and cherry. It is used as flavoring and in perfume. It can be obtained by oxidation of piperonyl alcohol or the...
- N-methylephedrine
- N-methylpseudoephedrine
- methylamine
List II chemicals
These chemicals are designated as those that are used in the manufacture of the controlled substances.- acetic anhydrideAcetic anhydrideAcetic anhydride, or ethanoic anhydride, is the chemical compound with the formula 2O. Commonly abbreviated Ac2O, it is the simplest isolatable acid anhydride and is a widely used reagent in organic synthesis...
- acetoneAcetoneAcetone is the organic compound with the formula 2CO, a colorless, mobile, flammable liquid, the simplest example of the ketones.Acetone is miscible with water and serves as an important solvent in its own right, typically as the solvent of choice for cleaning purposes in the laboratory...
- benzyl chlorideBenzyl chlorideBenzyl chloride, or α-chlorotoluene, is an organic compound with the formula C6H5CH2Cl. This colourless liquid is a reactive organochlorine compound that is a widely used chemical building block.-Preparation:...
- diethyl etherDiethyl etherDiethyl ether, also known as ethyl ether, simply ether, or ethoxyethane, is an organic compound in the ether class with the formula . It is a colorless, highly volatile flammable liquid with a characteristic odor...
- potassium permanganatePotassium permanganatePotassium permanganate is an inorganic chemical compound with the formula KMnO4. It is a salt consisting of K+ and MnO4− ions. Formerly known as permanganate of potash or Condy's crystals, it is a strong oxidizing agent. It dissolves in water to give intensely purple solutions, the...
- 2-butanone (or methyl ethyl ketone or MEK)
- tolueneTolueneToluene, formerly known as toluol, is a clear, water-insoluble liquid with the typical smell of paint thinners. It is a mono-substituted benzene derivative, i.e., one in which a single hydrogen atom from the benzene molecule has been replaced by a univalent group, in this case CH3.It is an aromatic...
- hydrochloric acidHydrochloric acidHydrochloric acid is a solution of hydrogen chloride in water, that is a highly corrosive, strong mineral acid with many industrial uses. It is found naturally in gastric acid....
(including anhydrous hydrogen chloride) - sulfuric acidSulfuric acidSulfuric acid is a strong mineral acid with the molecular formula . Its historical name is oil of vitriol. Pure sulfuric acid is a highly corrosive, colorless, viscous liquid. The salts of sulfuric acid are called sulfates...
- methyl isobutyl ketoneMethyl isobutyl ketoneMethyl isobutyl ketone is the organic compound with the formula 2CHCH2CCH3. This colourless liquid, a ketone, is widely used as a solvent.-Production:...
(MIBK) - sodium permanganateSodium permanganateSodium permanganate is the inorganic compound with the formula NaMnO4. It is closely related to the more commonly encountered potassium permanganate, but it is generally less desirable, because it is more expensive, absorbs water from the atmosphere, and has a low melting point...
Special Surveillance List
ChemicalsAll listed chemicals as specified in 21 CFR 1310.02 (a) or (b). This includes all chemical mixtures and all over-the-counter (OTC) products and dietary supplements which contain a listed chemical, regardless of their dosage form or packaging and regardless of whether the chemical mixture, drug product or dietary supplement is exempt from regulatory controls.
- AmmoniaAmmoniaAmmonia is a compound of nitrogen and hydrogen with the formula . It is a colourless gas with a characteristic pungent odour. Ammonia contributes significantly to the nutritional needs of terrestrial organisms by serving as a precursor to food and fertilizers. Ammonia, either directly or...
Gas - Ammonium formateAmmonium formateAmmonium formate, NH4HCO2, is the ammonium salt of formic acid. It is a colorless, hygroscopic, crystalline solid.-Uses:Pure ammonium formate decomposes into formamide and water when heated, and this is its primary use in industry...
- Bromobenzene
- CarbonyldiimidazoleCarbonyldiimidazole1,1'-Carbonyldiimidazole is an organic compound with the molecular formula 2CO. It is a white crystalline solid. It is often used for the coupling of amino acids for peptide synthesis and as a reagent in organic synthesis.-Preparation:...
- CyclohexanoneCyclohexanoneCyclohexanone is the organic compound with the formula 5CO. The molecule consists of six-carbon cyclic molecule with a ketone functional group. This colorless oil has an odor reminiscent of peardrop sweets as well as acetone. Over time, samples assume a yellow color due to oxidation...
- 1,1-Dichloro-1-fluoroethane1,1-Dichloro-1-fluoroethane1,1-Dichloro-1-fluoroethane is a haloalkane with the formula . It is one of the three isomers of dichlorofluoroethane.- Use :1,1-Dichloro-1-fluoroethane is mainly used as a refrigerant under the names R-141b or HCFC-141b.- Physico-chemical properties :...
(e.g. Freon 141B) - DiethylamineDiethylamineDiethylamine is a secondary amine with the molecular structure CH3CH2NHCH2CH3. It is a flammable, strongly alkaline liquid. It is miscible with water and ethanol. It is a colorless liquid which often appears brown due to impurities...
and its salts - 2,5-Dimethoxyphenethylamine and its salts
- FormamideFormamideFormamide, also known as methanamide, is an amide derived from formic acid. It is a clear liquid which is miscible with water and has an ammonia-like odor. It is used primarily for manufacturing sulfa drugs and synthesizing vitamins and as a softener for paper and fiber...
- Formic acidFormic acidFormic acid is the simplest carboxylic acid. Its chemical formula is HCOOH or HCO2H. It is an important intermediate in chemical synthesis and occurs naturally, most notably in the venom of bee and ant stings. In fact, its name comes from the Latin word for ant, formica, referring to its early...
- LithiumLithiumLithium is a soft, silver-white metal that belongs to the alkali metal group of chemical elements. It is represented by the symbol Li, and it has the atomic number 3. Under standard conditions it is the lightest metal and the least dense solid element. Like all alkali metals, lithium is highly...
Metal - Lithium aluminum hydride
- MagnesiumMagnesiumMagnesium is a chemical element with the symbol Mg, atomic number 12, and common oxidation number +2. It is an alkaline earth metal and the eighth most abundant element in the Earth's crust and ninth in the known universe as a whole...
Metal (Turnings) - Mercuric chloride
- N-MethylformamideN-MethylformamideN-Methylformamide is a colorless, nearly odorless, organic compound with molecular formula CH3NHCHO, which is a liquid at room temperature. It is infinitely soluble in water...
- Organomagnesium Halides (Grignard Reagents) (e.g. ethylmagnesium bromideEthylmagnesium bromideEthylmagnesium bromide is a Grignard reagent with formula C2H5MgBr or C2H5Mg+·Br−, namely a magnesium ion with a covalent bond to an ethyl group and an ionic bond to a bromine anion...
and phenylmagnesium bromidePhenylmagnesium bromidePhenylmagnesium bromide, with the simplified formula , is a magnesium-containing organometallic compound. It is so commonly used that it is commercially available as a solution in diethyl ether or tetrahydrofuran . Phenylmagnesium bromide is a Grignard reagent...
) - Phenylethanolamine and its salts
- Phosphorus pentachloride
- Potassium dichromate
- PyridinePyridinePyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one C-H group replaced by a nitrogen atom...
and its salts - Sodium dichromateSodium dichromateSodium dichromate is the chemical compound with the formula Na2Cr2O7. Usually, however, the salt is handled as its dihydrate Na2Cr2O7·2H2O. Virtually all chromium ore is processed via conversion to sodium dichromate. In this way, many millions of kilograms of sodium dichromate are produced...
- SodiumSodiumSodium is a chemical element with the symbol Na and atomic number 11. It is a soft, silvery-white, highly reactive metal and is a member of the alkali metals; its only stable isotope is 23Na. It is an abundant element that exists in numerous minerals, most commonly as sodium chloride...
Metal - Thionyl chlorideThionyl chlorideThionyl chloride is an inorganic compound with the formula SOCl2. It is a reactive chemical reagent used in chlorination reactions. It is a colorless, distillable liquid at room temperature and pressure that decomposes above 140 °C. Thionyl chloride is sometimes confused with sulfuryl...
- ortho-Toluidine
- Trichloromonofluoromethane (e.g. Freon-11, Carrene-2)
- 1,1,2-Trichloro-1,2,2-trifluoroethane1,1,2-Trichloro-1,2,2-trifluoroethaneTrichlorotrifluoroethane, also called 1,1,2-Trichloro-1,2,2-trifluoroethane or CFC-113 is a chlorofluorocarbon. It has the formula CCl2FC-ClF2....
(e.g. Freon 113)
Equipment
- Hydrogenators
- Tablet pressTablet pressA tablet press is a mechanical device that compresses powder into tablets of uniform size and weight. A press can be used to manufacture tablets of a wide variety of materials, including pharmaceuticals, illicit drugs such as MDMA, cleaning products, and cosmetics...
es - Encapsulating Machines
- 22 Liter Heating mantleHeating mantleHeating mantle or isomantle is a term for certain pieces of laboratory equipment used to apply heat to containers, as an alternative to other forms of heated bath...
s
External links
- List of chemicals in the Controlled Substances Act
- Title 21 of the Code of Federal Regulations, parts 1300-1499, which contain the regulations pertaining to watched chemicals and the reporting of transactions involving them (version effective April 1, 2008)