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Cytochrome b
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Cytochrome b/b6 is main subunit of transmembrane cytochrome bc1 and b6f complexes.
In the mitochondrion of eukaryotes and in aerobic prokaryotes, cytochrome b is a component of respiratory chain complex III - also known as the bc1 complex or ubiquinol-cytochrome c reductase. In plant chloroplasts and cyanobacteria, there is an analogous protein, cytochrome b6, a component of the plastoquinone-plastocyanin reductase , also known as the b6f complex.
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Encyclopedia
Cytochrome b/b6 is main subunit of transmembrane cytochrome bc1 and b6f complexes.
In the mitochondrion of eukaryotes and in aerobic prokaryotes, cytochrome b is a component of respiratory chain complex III - also known as the bc1 complex or ubiquinol-cytochrome c reductase. In plant chloroplasts and cyanobacteria, there is an analogous protein, cytochrome b6, a component of the plastoquinone-plastocyanin reductase , also known as the b6f complex. These complexes are involved in electron transport and the generation of ATP and thus play a vital role in the cell.
Cytochrome b/b6 is an integral membrane protein of approximately 400 amino acid residues that probably has 8 transmembrane segments. In plants and cyanobacteria, cytochrome b6 consists of two subunits encoded by the petB and petD genes. Cytochrome b/b6 non-covalently binds two heme groups, known as b562 and b566. Four conserved histidine residues are postulated to be the ligands of the iron atoms of these two heme groups.
Mutations in cytochrome b primarily result in exercise intolerance in human patients; though more rare, severe mutli-system pathologies have also been reported (FEBS J. 2005 Jul;272(14):3583-92).
Human proteins containing this domain
CYTB
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