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Cubeb

Cubeb

Overview
Cubeb (Piper cubeba), or tailed pepper, is a plant in genus
Genus
In biology, a genus is a taxonomic unit used in the classification of living and fossil organisms. The term comes from Latin genus "descent, family, type, gender" , cognate with – genos, "race, stock, kin" ..In addition, genus is a taxonomic rank in the hierarchy In biology, a genus (plural:...

 Piper
Piper (genus)
Piper, the pepper plants or pepper vines , are an economically and ecologically important genus in the family Piperaceae...

, cultivated for its fruit
Fruit
The term fruit has different meanings dependent on context, and the term is not synonymous in food preparation and biology. Fruits are the means by which flowering plants disseminate seeds, and the presence of seeds indicates that a structure is most likely a fruit, though not all seeds come from...

 and essential oil
Essential oil
An essential oil is a concentrated, hydrophobic liquid containing volatile aroma compounds from plants. Essential oils are also known as volatile or ethereal oils, or simply as the "oil of" the plant from which they were extracted, such as oil of clove. An oil is "essential" in the sense that it...

. It is mostly grown in Java and Sumatra
Sumatra
Sumatra is an island in western Indonesia, westernmost of the Sunda Islands. It is the largest island entirely in Indonesia , and the sixth largest island in the world .-Etymology:Sumatra was known in ancient times by the Sanskrit...

, hence sometimes called Java pepper. The fruits are gathered before they are ripe, and carefully dried. Commercial cubebs consist of the dried berries, similar in appearance to black pepper
Black pepper
Black pepper is a flowering vine in the family Piperaceae, cultivated for its fruit, which is usually dried and used as a spice and seasoning. The fruit, known as a peppercorn when dried, is a small drupe approximately five millimetres in diameter, dark red when fully mature, containing a single...

, but with stalks attached — the "tails" in "tailed pepper".
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Encyclopedia
Cubeb (Piper cubeba), or tailed pepper, is a plant in genus
Genus
In biology, a genus is a taxonomic unit used in the classification of living and fossil organisms. The term comes from Latin genus "descent, family, type, gender" , cognate with – genos, "race, stock, kin" ..In addition, genus is a taxonomic rank in the hierarchy In biology, a genus (plural:...

 Piper
Piper (genus)
Piper, the pepper plants or pepper vines , are an economically and ecologically important genus in the family Piperaceae...

, cultivated for its fruit
Fruit
The term fruit has different meanings dependent on context, and the term is not synonymous in food preparation and biology. Fruits are the means by which flowering plants disseminate seeds, and the presence of seeds indicates that a structure is most likely a fruit, though not all seeds come from...

 and essential oil
Essential oil
An essential oil is a concentrated, hydrophobic liquid containing volatile aroma compounds from plants. Essential oils are also known as volatile or ethereal oils, or simply as the "oil of" the plant from which they were extracted, such as oil of clove. An oil is "essential" in the sense that it...

. It is mostly grown in Java and Sumatra
Sumatra
Sumatra is an island in western Indonesia, westernmost of the Sunda Islands. It is the largest island entirely in Indonesia , and the sixth largest island in the world .-Etymology:Sumatra was known in ancient times by the Sanskrit...

, hence sometimes called Java pepper. The fruits are gathered before they are ripe, and carefully dried. Commercial cubebs consist of the dried berries, similar in appearance to black pepper
Black pepper
Black pepper is a flowering vine in the family Piperaceae, cultivated for its fruit, which is usually dried and used as a spice and seasoning. The fruit, known as a peppercorn when dried, is a small drupe approximately five millimetres in diameter, dark red when fully mature, containing a single...

, but with stalks attached — the "tails" in "tailed pepper". The dried pericarp is wrinkled, its color ranges from grayish-brown to black. The seed
Seed
A seed , referred to as a kernel in some plants, is a small embryonic plant enclosed in a covering called the seed coat, usually with some stored food. It is the product of the ripened ovule of gymnosperm and angiosperm plants which occurs after fertilization and some growth within the mother plant...

 is hard, white and oily. The odor of cubebs is described as agreeable and aromatic. The taste, pungent, acrid, slightly bitter and persistent. It has been described as tasting like allspice
Allspice
Allspice, also called Jamaica pepper, Kurundu, Myrtle pepper, pimenta, or newspice, is a spice which is the dried unripe fruit of Pimenta dioica , a mid-canopy tree native to the Greater Antilles, southern Mexico and Central America, now cultivated in many warm parts of the world...

, or like a cross between allspice and black pepper.

Cubeb came to Europe via India
India
India, officially the Republic of India , is a country in South Asia. It is the seventh-largest country by geographical area, the second-most populous country, and the most populous democracy in the world. Bounded by the Indian Ocean on the south, the Arabian Sea on the west, and the Bay of Bengal...

 through the trade with the Arabs. The name cubeb comes from Arabic
Arabic language
Arabic is a Central Semitic language, thus related to and classified alongside other Semitic languages such as Hebrew and the Neo-Aramaic languages. In terms of speakers, the Arabic macrolanguage is the largest member of the Semitic language family. It is spoken by more than 280 million people as...

  , which is of unknown origin, by way of Old French
Old French
Old French was the Romance dialect continuum spoken in territories which span roughly the northern half of modern France and parts of modern Belgium and Switzerland from around 900 to 1300...

 quibibes. Cubeb is mentioned in alchemical writings
Alchemy
Alchemy is both a philosophy and a practice with an aim of achieving ultimate wisdom as well as immortality, involving the improvement of the alchemist as well as the making of several substances described as possessing unusual properties...

 by its Arabic name. In his Theatrum Botanicum, John Parkinson
John Parkinson (botanist)
John Parkinson was the last of the great English herbalists and one of the first of the great English botanists. He was apothecary to James I and a founding member of the Worshipful Society of Apothecaries in December 1617, and was later Royal Botanist to Charles I...

 tells that the king of Portugal prohibited the sale of cubeb in order to promote black pepper
Black pepper
Black pepper is a flowering vine in the family Piperaceae, cultivated for its fruit, which is usually dried and used as a spice and seasoning. The fruit, known as a peppercorn when dried, is a small drupe approximately five millimetres in diameter, dark red when fully mature, containing a single...

 (Piper nigrum) around 1640. It experienced a brief resurgence in 19th-century Europe for medicinal uses, but has practically vanished from the European market since. It continues to be used as a flavoring agent
Flavor
Flavor or flavour is the sensory impression of a food or other substance, and is determined mainly by the chemical senses of taste and smell. The "trigeminal senses", which detect chemical irritants in the mouth and throat, may also occasionally determine flavor...

 for gin
Gin
Gin is a spirit flavoured primarily with juniper berries. Distilled gin is made by redistilling white grain spirit which has been flavoured with juniper berries. Compound gin is made by flavouring neutral grain spirit with juniper berries without redistilling.The most common style of gin,...

s and cigarette
Cigarette
A cigarette is a product consumed through smoking and manufactured out of cured and finely cut tobacco leaves and reconstituted tobacco, often combined with other additives, then rolled or stuffed into a paper-wrapped cylinder...

s in the West, and as a seasoning for food in Indonesia
Indonesia
The Republic of Indonesia is a country in Southeast Asia and Oceania. Indonesia comprises 17,508 islands. With an estimated population of around 237 million people, it is the world's fourth most populous country, with the world's largest population of Muslims.Indonesia is a republic, with an...

.

History



In the 4th century BC, Theophrastus
Theophrastus
Theophrastus , a Greek native of Eressos in Lesbos, was the successor of Aristotle in the Peripatetic school. His interests were wide-ranging, extending from biology and physics to ethics and metaphysics. His two surviving botanical works, Enquiry into Plants and On the Causes of Plants, were an...

 mentioned komakon, including it with cinnamon
Cinnamon
Cinnamon is a small evergreen tree belonging to the family Lauraceae, native to Sri Lanka, or the spice obtained from the tree's bark...

 and cassia
Cassia
Cassia is an evergreen tree native to southern China, Bangladesh, India, and Vietnam. Like its close relative Cinnamomum verum, also known as "Ceylon cinnamon", it is used primarily for its aromatic bark, which is used as a spice...

 as an ingredient in aromatic confections. Guillaume Budé
Guillaume Budé
Guillaume Budé was a French scholar.-Life:Budé was born in Paris. He went to the University of Orléans to study law, but for several years, being possessed of ample means, he led an idle and dissipated life...

 and Claudius Salmasius
Claudius Salmasius
Claudius Salmasius is the Latin name of Claude Saumaise , a French classical scholar.-Life:He was born at Semur-en-Auxois in Burgundy. His father, a counsellor of the parlement of Dijon, sent him, at the age of sixteen, to Paris, where he became intimate with Isaac Casaubon...

 have identified komakon with cubeb, probably due to the resemblance which the word bears to the Javanese
Javanese language
Javanese language is the language of the people in the central and eastern parts of the island of Java, in Indonesia. In addition, there are also some pockets of Javanese speakers in the northern coast of western Java...

 name of cubeb, kumukus. This is seen as a curious evidence of Greek trade with Java in a time earlier than that of Theophrastus. It is unlikely Greeks acquired them from somewhere else, since Javanese growers protected their monopoly
Monopoly
In economics, a monopoly exists when a specific individual or an enterprise has sufficient control over a particular product or service to determine significantly the terms on which other individuals shall have access to it...

 of the trade by sterilizing the berries by scalding, ensuring that the vines were unable to be cultivated elsewhere.

In the Tang Dynasty
Tang Dynasty
The Tang Dynasty was an imperial dynasty of China preceded by the Sui Dynasty and followed by the Five Dynasties and Ten Kingdoms Period. It was founded by the Li family, who seized power during the decline and collapse of the Sui Empire...

, cubeb was brought to China from Srivijaya
Srivijaya
Srivijaya or Sriwijaya was an ancient Malay kingdom on the island of Sumatra, Southeast Asia which influenced much of the Maritime Southeast Asia. The earliest solid proof of its existence dates from the 7th century; a Chinese monk, I-Tsing, wrote that he visited Srivijaya in 671 for 6 months...

. In India the spice came to be called kabab chini, that is, "Chinese cubeb", possibly because the Chinese had a hand in its trade, but more likely because it was an important item in the trade with China. In China this pepper was called both vilenga, and vidanga, the cognate Sanskrit
Sanskrit
Sanskrit is a historical Indo-Aryan language, one of the liturgical languages of Hinduism and Buddhism, and one of the 22 official languages of India. It is also declared as a classical language by the government of India....

 word. Li Hsun thought it grew on the same tree as black pepper. Tang physicians administered it to restore appetite, cure "demon vapors", darken the hair, and perfume the body. However, there is no evidence showing that cubeb was used as a condiment in China.

The Book of One Thousand and One Nights
The Book of One Thousand and One Nights
One Thousand and One Nights is a collection of Middle Eastern and South Asian stories and folk tales compiled in Arabic during the Islamic Golden Age...

, compiled in the 9th century, mentions cubeb as a remedy for infertility, showing it was already used by Arabs for medicinal purposes. Cubeb was introduced to Arabic cuisine
Arab cuisine
Arab cuisine is defined as the various regional cuisines spanning the Arab World from Iraq to Morocco to Somalia to Yemen, and incorporating Levantine, Egyptian and others...

 around the 10th century. The Travels of Marco Polo
The Travels of Marco Polo
The Travels of Marco Polo is the usual English title of Marco Polo's travel book, nicknamed Il Milione or Le Livre des Merveilles...

, written in late 13th century, describes Java as a producer of cubeb, along with other valuable spices. In the 14th century, cubeb was imported into Europe from the Grain Coast, under the name of pepper, by merchants of Rouen
Rouen
Rouen is the historical capital city of Normandy, in northern France on the River Seine, and currently the capital of the Haute-Normandie region. Once one of the largest and most prosperous cities of medieval Europe, Rouen was the seat of the Exchequer of Normandy in the Middle Ages...

 and Lippe
Lippe
Lippe is a Kreis in the east of North Rhine-Westphalia, Germany. Neighboring districts are Herford, Minden-Lübbecke, Schaumburg, Hameln-Pyrmont, Holzminden, Höxter, Paderborn, Gütersloh, and district-free Bielefeld....

. A 14th-century morality tale
Morality play
The Morality play is a genre of Medieval and early Tudor theatrical entertainment. In their own time, these plays were known as "interludes," a broader term given to dramas with or without a moral theme. Morality plays are a type of allegory in which the protagonist is met by personifications of...

 exemplifying gluttony
Gluttony
Gluttony, derived from the Latin gluttire meaning to gulp down or swallow, means over-indulgence and over-consumption of food, drink, or intoxicants to the point of waste...

 by the Franciscan writer Francesc Eiximenis
Francesc Eiximenis
Francesc Eiximenis or Francesc Examenis was a Catalan Franciscan priest, encyclopedist and writer.-Life:Eiximenis entered the order of the Friars Minor at Barcelona sometime before 1351, when he was ordained subdeacon, but his first recommendable literary works were produced much later...

 describes the eating habits of a worldly cleric who consumes a bizarre concoction of egg yolks with cinnamon and cubeb after his baths, probably as an aphrodisiac.

Cubeb was thought by the people of Europe to be repulsive to demons, just as it was by the people of China. Ludovico Maria Sinistrari, a Catholic priest
Holy Orders
The term Holy Orders is used by many Christian churches to refer to ordination or to a group of individuals who are set apart for a special role or ministry....

 who wrote about methods of exorcism
Exorcism
Exorcism is the practice of evicting demons or other spiritual entities from a person or place which they are believed to have possessed...

 in the late 17th century, includes cubeb as an ingredient in an incense to ward off incubus
Incubus (demon)
An incubus is a demon in male form supposed to lie upon sleepers, especially women, in order to have sexual intercourse with them, according to a number of mythological and legendary traditions. Its female counterpart is the succubus. An incubus may pursue sexual relations with a woman in order...

. Even today, his formula for the incense is quoted by neopagan authors, some of whom also claim that cubeb can be used in love sachets and spells.

After the prohibition of sale, culinary use of cubeb decreased dramatically in Europe, and only its medicinal application continued to the 19th century. In the early 20th century, cubeb was regularly shipped from Indonesia to Europe and the United States. The trade gradually diminished to an average of annually, and practically ceased after 1940.

Chemistry


The dried cubeb berries contain essential oil consisting monoterpene
Monoterpene
Monoterpenes are a class of terpenes that consist of two isoprene units and have the molecular formula C10H16. Monoterpenes may be linear or contain rings...

s (sabinene
Sabinene
Sabinene is a natural bicyclic monoterpene with the molecular formula C10H16. It is isolated from the essential oils of a variety of plants including holm oak and Norway spruce...

 50%, α-thujene
Thujene
Thujene is a natural organic compound classified as a monoterpene. It is found in the essential oils of a variety of plants, and contributes pungency to the flavor of some herbs such as Summer savory....

, and carene
Carene
Carene, or delta-3-carene, is a bicyclic monoterpene which occurs naturally as a constituent of turpentine, with a content as high as 42% depending on the source. Carene has a sweet and pungent odor. It is not soluble in water, but miscible with fats and oils....

) and sesquiterpene
Sesquiterpene
Sesquiterpenes are a class of terpenes that consist of three isoprene units and have the molecular formula C15H24. Like monoterpenes, sesquiterpenes may be acyclic or contain rings, including many unique combinations...

s (caryophyllene
Caryophyllene
Caryophyllene , or -β-caryophyllene, is a natural bicyclic sesquiterpene that is a constituent of many essential oils, especially clove oil, the oil from the stems and flowers of Syzygium aromaticum , the essential oil of hemp Cannabis sativa, and rosemary Rosmarinus oficinalis...

, copaene
Copaene
Copaene, or more precisely, α-copaene, is the common chemical name of an oily liquid hydrocarbon that is found in a number of essential oil-producing plants. The name is derived from that of the resin-producing tropical copaiba tree, Copaifera langsdorfii, from which the compound was first...

, α- and β-cubebene, δ-cadinene
Cadinene
Cadinene is the trivial chemical name of a number of isomeric hydrocarbons that occur in a wide variety of essential oil-producing plants. The name is derived from that of the Cade juniper , the wood of which yields an oil from which cadinene isomers were first isolated.Chemically, the cadinenes...

, germacrene
Germacrene
Germacrene, or occasionally germacrane, refers to a subset of volatile organic hydrocarbons, specifically, sesquiterpenes. Germacrenes are typically produced in a number plant species for their antimicrobial and insecticidal properties, though they also play a role as insect pheromones...

), the oxides 1,4- and 1,8-cineole and the alcohol cubebol
Cubebol
Cubebol is a natural sesquiterpene alcohol first identified in cubeb oil. It was patented as a cooling agent in 2001 by Firmenich, an international flavorcompany. The taste of cubebol is cooling and refreshing....

.

About 15% of a volatile oil is obtained by distilling cubebs with water. Cubebene, the liquid portion, has the formula C15H24. It is a pale green or blue-yellow viscous liquid with a warm woody, slightly camphoraceous odor. After rectification with water, or on keeping, this deposits rhombic crystals of camphor
Camphor
Camphor is a waxy, white or transparent solid with a strong, aromatic odor. It is a terpenoid with the chemical formula C10H16O. It is found in wood of the camphor laurel , a large evergreen tree found in Asia and also of Dryobalanops aromatica, a giant of the Bornean forests...

 of cubebs.

Cubebin (C10H10O3) is a crystalline substance existing in cubebs, discovered by Eugène Soubeiran
Eugène Soubeiran
Eugène Soubeiran was a renowned French scientist who served as chief pharmacist at the Pitié-Salpêtrière Hospital. He was one of three researchers who discovered chloroform independently of one another...

 and Capitaine in 1839. It may be prepared from cubebene, or from the pulp left after the distillation of the oil. The drug
Medication
A pharmaceutical drug, also referred to as medicine, medication or medicament, can be loosely defined as any chemical substance intended for use in the medical diagnosis, cure, treatment, or prevention of disease.- Classification :...

, along with gum
Natural gum
Natural gums are polysaccharides of natural origin, capable of causing a large viscosity increase in solution, even at small concentrations. In the food industry they are used as thickening agents, gelling agents, emulsifiers and stabilisers...

, fatty oils, and malates of magnesium
Magnesium
Magnesium is a chemical element with the symbol Mg, atomic number 12 and common oxidation number +2. It is an alkaline earth metal and the eighth most abundant element in the earth's crust by mass, although ninth in the Universe as a whole...

 and calcium
Calcium
Calcium is the chemical element with the symbol Ca and atomic number 20. It has an atomic mass of 40.078 amu. Calcium is a soft grey alkaline earth metal, and is the fifth most abundant element by mass in the Earth's crust...

, contains also about 1% of cubebic acid, and about 6% of a resin
Resin
Resin is a hydrocarbon secretion of many plants, particularly coniferous trees. It is valued for its chemical constituents and uses, such as varnishes and adhesives, as an important source of raw materials for organic synthesis, or for incense and perfume. Fossilized resins are the source of amber...

. The dose of the fruit is 30 to 60 grains
Grain (measure)
A grain is a unit of measurement of mass that is based upon the mass of a single seed of a typical cereal. Historically, in Europe, the average masses of wheat and barley grain were used to define units of mass...

, and the British Pharmacopoeia
British Pharmacopoeia
The British Pharmacopoeia is an annual published collection of quality standards for UK medicinal substances. It is used by individuals and organizations involved in pharmaceutical research, development, manufacture and testing....

 contains a tincture with a dose of 4 to 1 dram
Avoirdupois
The avoirdupois system is a system of weights based on a pound of sixteen ounces. It is the everyday system of weight used in the United States, and is still widely used to varying degrees by many people in Canada, the United Kingdom, and some other former British colonies despite the official...

.

Medicinal



In India, Sanskrit texts included cubeb in various remedies. Charaka and Sushruta prescribed a cubeb paste as a mouthwash, and the use of dried cubebs internally for oral and dental diseases, loss of voice, halitosis
Halitosis
Halitosis, or most commonly bad breath are terms used to describe noticeably unpleasant odors exhaled in breathing – whether the smell is from an oral source due to bacteria....

, fevers, and cough. Unani
Unani
Unani or Yunani means "Greek", and has its origins in the Greek word Ἰωνία or Ἰωνίη , a placename given to a Greek populated coastal region of Anatolia....

 physicians use a paste of the cubeb berries externally on male and female genitals to intensify sexual pleasure during coitus. Due to this attributed property, cubeb was called "Habb-ul-Uruus".

In traditional Chinese medicine
Traditional Chinese medicine
Traditional Chinese Medicine, also known as TCM , includes a range of traditional medical practices originating in China. Although well accepted in the mainstream of medical care throughout East Asia, it is considered an alternative medical system in much of the western world.TCM practices include...

 cubeb is used for its alleged warming property. In Tibetan medicine
Traditional Tibetan medicine
Tibetan medicine is a centuries-old traditional medical system that employs a complex approach to diagnosis, incorporating techniques such as pulse analysis and urinalysis, and utilizes behavior and dietary modification, medicines composed of natural materials and physical therapies Tibetan...

, cubeb (ka ko la in Tibetan
Tibetan language

The Tibetan languages are a cluster of mutually unintelligible Tibeto-Burman languages spoken primarily by Tibetan peoples who live across a wide area of eastern Central Asia bordering South Asia, including the Tibetan Plateau and the northern Indian subcontinent in Baltistan, Ladakh, Nepal,...

) is one of bzang po drug, six fine herbs beneficial to specific organs in the body, with cubeb assigned to the spleen
Spleen
The spleen is an organ found in virtually all vertebrate animals with important roles in regard to red blood cells and the immune system In humans, it is located in the left upper quadrant of the abdomen. It removes old red blood cells, holds a reserve in case of hemorrhagic shock, especially in...

.

Arab physicians of the Middle Ages
Middle Ages
The Middle Ages of European history is a period of European history covering roughly a millennium in the 5th century through 16th centuries. More specific starting and ending points are sometimes adopted by scholars to suit their respective specializations or current focus...

 were usually versed in alchemy
Alchemy
Alchemy is both a philosophy and a practice with an aim of achieving ultimate wisdom as well as immortality, involving the improvement of the alchemist as well as the making of several substances described as possessing unusual properties...

, and cubeb was used, under the name kababa, when preparing the water of al butm. The Book of One Thousand and One Nights mentions cubeb as a main ingredient in making an aphrodisiac remedy for infertility:
The mixture, called "seed-thickener", is given to Shams-al-Din, a wealthy merchant who had no child, with the instruction that he must eat the paste two hours before having intercourse with his wife. According to the story, the merchant did get the child he desired after following these instructions. Other Arab authors wrote that cubeb rendered the breath fragrant, cured affections of the bladder, and that eating it "enhances the delight of coitus".

In 1654, Nicholas Culpeper
Nicholas Culpeper
Nicholas Culpeper was an English botanist, herbalist, physician, and astrologer. His published books, The English Physitian and the Complete Herbal , contain a rich store of pharmaceutical and herbal knowledge.Culpeper spent the greater part of his life in the English outdoors cataloguing...

 wrote in the London Dispensatorie that cubebs were "hot and dry in the third degree... (snip) they cleanse the head of flegm and strengthen the brain, they heat the stomach and provoke lust". A later edition in 1826 informed the reader that "the Arabs call them Quabebe, and Quabebe Chine: they grow plentifully in Java, they stir up venery. (snip) ...and are very profitable for cold griefs of the womb".

The modern use of cubeb in England as a drug dates from 1815. There were various preparations, including oleum cubebae (oil of cubeb), tincture
Tincture
In medicine, a tincture is an alcoholic extract or solution of a non-volatile substance; . To qualify as a tincture, the alcoholic extract is to have an ethanol percentage of at least 40-60%...

s, fluid extracts, oleo-resin compounds, and vapors, which were used for throat complaints. A small percentage of cubeb was commonly included in lozenge
Lozenge
A lozenge , often referred to as a diamond, is a form of rhombus. The definition of lozenge is not strictly fixed, and it is sometimes used simply as a synonym for rhombus. Most often, though, lozenge refers to a thin rhombus—a rhombus with acute angles of 45°...

s designed to alleviate bronchitis
Bronchitis
Acute bronchitis is an inflammation of the large bronchi in the lungs that is usually caused by viruses or bacteria and may last several days or weeks. Characteristic symptoms include cough, sputum production, and shortness of breath and wheezing related to the obstruction of the inflamed airways...

, in which the antiseptic
Antiseptic
Antiseptics are antimicrobial substances that are applied to living tissue/skin to reduce the possibility of infection, sepsis, or putrefaction...

 and expectoral properties of the drug are useful. The most important therapeutic application of this drug, however, was in treating gonorrhea
Gonorrhea
Gonorrhea is a common sexually transmitted infection caused by the bacterium Neisseria gonorrhoeae...

, where its antiseptic action was of much value. William Wyatt
William Wyatt
William Wyatt was a pioneer settler and philanthropist in Australia.-Early life:Wyatt was born in Plymouth, Devon, England, the son of Richard Wyatt. He was apprenticed at 16 years of age to a Plymouth surgeon, Thomas Stewart. Wyatt continued to study medicine and obtained the qualification of...

 Squire wrote in 1908 that cubebs "act specifically on the genito-urinary mucous membrane
Mucous membrane
The mucous membranes are linings of mostly endodermal origin, covered in epithelium, which are involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the...

. (They are) given in all stages of gonorrhea
Gonorrhea
Gonorrhea is a common sexually transmitted infection caused by the bacterium Neisseria gonorrhoeae...

". As compared with copaiba
Copaiba
Copaiba is a stimulant oleoresin obtained from the trunk of several pinnate-leaved South American leguminous trees . The thick, transparent exudate varies in color from light gold to dark brown, depending on the ratio of resin to essential oil. Copaiba is used in making varnishes and lacquers...

 in this connection cubeb has the advantages of being less disagreeable to take and somewhat less likely to disturb the digestive apparatus in prolonged administration.

The volatile oil, oleum cubebae, was the form in which cubeb is most commonly used as a drug, the dose being 5 to 20 minim
Minim (unit)
The minim is a unit of volume in both the imperial and US customary systems of measurement. Specifically it is of a fluidram or of a fluid ounce....

s, which may be suspended in mucilage
Mucilage
Mucilage is a polar glycoprotein; an exopolysaccharide; a polymer produced by most plants and some microorganisms.It occurs in various parts of nearly all classes of plant, usually in relatively small percentages, and is frequently associated with other substances, such as tannins and...

 or given after meals in a wafer
Wafer (cooking)
In cooking, a wafer is a crisp, often sweet, very thin, flat, and dry biscuit, too often used to decorate ice cream. Wafers can also be made into cookies with cream flavoring sandwiched between them...

. The drug exhibited the typical actions of a volatile oil, but exerted some of these to an exceptional degree. As such, it was liable to cause a cutaneous erythema
Erythema
Erythema is redness of the skin, which can be caused by several things, including capillary congestion.-Causes:It can be caused by infection, massage, electrical treatment, acne medication, allergies, exercise, solar radiation , cutaneous radiation syndrome, or waxing and plucking of the hairs...

 in the course of its excretion by the skin, had a marked diuretic
Diuretic
A diuretic is any drug that elevates the rate of urination and thus provides a means of forced diuresis. There are several categories of diuretics...

 action, and was a fairly efficient disinfectant of the urinary passages. Its administration caused the appearance in the urine of a salt of cubebic acid which was precipitated by heat or nitric acid
Nitric acid
Nitric acid , also known as aqua fortis and spirit of nitre, is a highly corrosive and toxic strong acid.Colorless when pure older samples tend to acquire a stronger yellow cast due to the accumulation of oxides of nitrogen. If the solution contains more than 86% nitric acid, it is referred to as...

, and was therefore liable to be mistaken for albumin
Human serum albumin
Human serum albumin is the most abundant protein in human blood plasma. It is produced in the liver. Albumin comprises about half of the blood serum protein. It is soluble and monomeric....

, when these two most common tests for the occurrence of albuminuria
Albuminuria
Albuminuria is a pathological condition wherein albumin is present in the urine. It is a type of proteinuria.-Measurement:The amount of protein being lost in the urine can be quantified by collecting the urine for 24 hours, measuring a sample of the pooled urine, and extrapolating to the volume...

 were applied.

The National Botanic Pharmacopoeia printed in 1921 tells that cubeb was "an excellent remedy for flour albus or whites."

Culinary


In Europe, cubeb was one of the valuable spices during the Middle Ages. It was ground as a seasoning
Seasoning
Seasoning is the process of imparting flavor to, or improving the flavor of, food.- General meaning :Seasonings include herbs, spices, which are themselves frequently referred to as "seasonings"...

 for meat or used in sauces. A medieval recipe includes cubeb in making
sauce sarcenes, which consists of almond milk
Almond milk
Almond milk is a milky drink made from ground almonds. Unlike animal milk, almond milk contains no cholesterol or lactose. It can be used as a substitute for animal milk in many recipes, and is also completely vegan. Commercial almond milk products come in plain, vanilla, or chocolate flavors....

 and several spices. As an aromatic confectionery, cubeb was often candied and eaten whole.

Cubeb reached Africa by way of the Arabs. In Moroccan cuisine, cubeb is used in savory dishes and in pastries like
markouts, little diamonds of semolina
Semolina
Semolina is the purified middlings of durum wheat used in making pasta; also, the coarse middlings are used for breakfast cereals and puddings.-Name:...

 with honey and dates. It also appears occasionally in the list of ingredients for the famed spice mixture
Ras el hanout
Ras el hanout
Ras el hanout is a popular blend of herbs and spices that is used across the Middle East and North Africa. The name means "head of the shop" in Arabic, and refers to a mixture of the best spices a seller has to offer....

. In Indonesian cuisine, especially in Indonesian gulés (curries), cubeb is frequently used. Ocet Kubebowy, a vinegar
Vinegar
Vinegar is an acidic liquid processed from the fermentation of ethanol in a process that yields its key ingredient, acetic acid. It also may come in a diluted form. The acetic acid concentration typically ranges from 4 to 8 percent by volume for table vinegar and higher concentrations for pickling...

 infused with cubeb, cumin and garlic, was used for meat marinades in Poland
Poland
Poland , officially the Republic of Poland , is a country in Central Europe . Poland is bordered by Germany to the west; the Czech Republic and Slovakia to the south; Ukraine, Belarus and Lithuania to the east; and the Baltic Sea and Kaliningrad Oblast, a Russian exclave, to the north...

 during the 14th century. Cubeb can still be used to enhance the flavor of savory soups.

Cigarettes and spirits



Cubeb was frequently used in the form of cigarette
Cigarette
A cigarette is a product consumed through smoking and manufactured out of cured and finely cut tobacco leaves and reconstituted tobacco, often combined with other additives, then rolled or stuffed into a paper-wrapped cylinder...

s for asthma
Asthma
Asthma is a predisposition to chronic inflammation of the lungs in which the airways are reversibly narrowed. Asthma affects 7% of the population of the United States, and 300 million worldwide...

, chronic pharyngitis
Pharyngitis
Pharyngitis is an inflammation of the throat or pharynx. In most cases it is painful and the initial infection can extent for a lengthy time period, and is often referred to as a sore throat....

 and hay fever
Hay Fever
Hay Fever is a comic play written by Noël Coward in 1924 and first produced in 1925 with Marie Tempest as the first Judith Bliss.Laura Hope Crewes played the role in New York...

. Edgar Rice Burroughs
Edgar Rice Burroughs
Edgar Rice Burroughs was an American author, best known for his creation of the jungle hero Tarzan and the heroic Mars adventurer John Carter, although he produced works in many genres.-Biography:...

, being fond of smoking cubeb cigarettes, humorously stated that if he had not smoked so many cubebs, there might never have been
Tarzan
Tarzan
Tarzan is a fictional character, an archetypal feral child raised in the African jungle by fictional great apes, who later returns to civilization only to largely reject it and return to the wild as a heroic adventurer...

. "Marshall's Prepared Cubeb Cigarettes" was a popular brand, with enough sales to still be made during World War II. Occasionally, marijuana users claimed that smoking marijuana is no more harmful than smoking cubeb.

Cubeb oil was included in the list of ingredients found in cigarettes, published by the Tobacco Prevention and Control Branch of North Carolina
North Carolina
North Carolina is a state located on the Atlantic Seaboard in the southeastern United States. The state borders South Carolina and Georgia to the south, Tennessee to the west and Virginia to the north. North Carolina contains 100 counties...

's Department of Health and Human Services.

Bombay Sapphire
Bombay Sapphire
Bombay Sapphire is a brand of gin distributed by Bacardi, launched in 1987, having been named via a competitive process whereby a number of leading Madison Avenue agencies were played off against each other. The name hints at the origins of the gin's popularity in the India of the days of the...

 gin is flavored with botanicals including cubeb and grains of paradise. The brand was launched in 1987, but its maker claims that it is based on a secret recipe dating to 1761. Pertsovka, a dark brown Russian pepper vodka
Vodka
Vodka is a clear distilled liquor composed of water and ethyl alcohol, made from a fermented substance of either grain, rye, wheat, potatoes, or sugar beet molasses; it also might contain trace amounts of other substances, either a flavour or unintended impurities...

 with a burning taste, is prepared from infusion of cubeb and capsicum
Capsicum
Capsicum is a genus of plants from the nightshade family native to the Americas, where it was cultivated for thousands of years by the people of the tropical Americas, and is now cultivated worldwide. Some of the members of Capsicum are used as spices, vegetables, and medicines...

 peppers.

Other



Cubeb is sometimes used to adulterate
Adulterant
Adulterants are chemical substances which should not be contained within other substances for legal or other reasons. Adulterants may be intentionally added to substances to reduce manufacturing costs, or for some deceptive or malicious purpose...

 the essential oil
Essential oil
An essential oil is a concentrated, hydrophobic liquid containing volatile aroma compounds from plants. Essential oils are also known as volatile or ethereal oils, or simply as the "oil of" the plant from which they were extracted, such as oil of clove. An oil is "essential" in the sense that it...

 of Patchouli
Patchouli
Patchouli is a species from the genus Pogostemon and a bushy herb of the mint family, with erect stems, reaching two or three feet in height and bearing small pale pink-white flowers...

, which requires caution for Patchouli users. In turn, cubeb is adulterated by Piper baccatum (also known as the "climbing pepper of Java") and Piper caninum.

Cubeb berries are used in love-drawing magic
Magic (paranormal)
Magic, sometimes known as sorcery, is the practice of consciousness manipulation and/or autosuggestion to achieve a desired result, usually by techniques described in various conceptual systems...

 spells by practitioners of hoodoo, an African-American form of folk magic.

In 2000, Shiseido
Shiseido
is a major Japanese hair care and cosmetics producer and the oldest cosmetics company in the world.-History:Arinobu Fukuhara, former head pharmacist to the Japanese Imperial Navy, established the Shiseido Pharmacy in 1872. After a visit to the United States and Europe, Arinobu added a soda fountain...

, a well-known Japanese cosmetics company, patent
Patent
A patent is a set of exclusive rights granted by a state to an inventor or their assignee for a limited period of time in exchange for a public disclosure of an invention....

ed a line of anti-aging products containing formulas made from several herbs, including cubeb.

In 2001, the Switzerland-based company Firmenich
Firmenich
Firmenich SA is a private business specialising in flavors and fragrances and is a major worldwide chemical manufacturer. Their fragrances and flavors are generally used in perfumes, cosmetics, beverages, food, and other household products. Worldwide, Firmenich currently employs approximately...

 patented cubebol
Cubebol
Cubebol is a natural sesquiterpene alcohol first identified in cubeb oil. It was patented as a cooling agent in 2001 by Firmenich, an international flavorcompany. The taste of cubebol is cooling and refreshing....

, a compound found in cubeb oil, as a cooling and refreshing agent. The patent describes application of cubebol as a refreshing agent in various products, ranging from chewing gum
Chewing gum
Chewing gum is a type of confection traditionally made of chicle, a natural latex product, or synthetic rubber known as polyisobutylene, which is a non-vulcanisable form of the butyl rubber used for inner tubes or to line tubeless tires. For reasons of economy and quality, many modern chewing gums...

 to sorbets, drinks, toothpaste, and
gelatin
Gelatin
Gelatin is a translucent, colorless, odorless, brittle, nearly tasteless solid substance, derived from the collagen inside animals' skin and bones. It is commonly used as a gelling agent in food, pharmaceuticals, photography, and cosmetic manufacturing. Substances containing gelatin or functioning...

-based confectioneries.