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Cornification

 

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Cornification



 
 
Cornification is the process of forming an epidermal barrier in stratified squamous epithelial tissue.

At cellular level cornification is characterised by



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Cornification is the process of forming an epidermal barrier in stratified squamous epithelial tissue.

At cellular level cornification is characterised by

  • production of keratin
    Keratin

    Keratins are a family of fibrous protein; tough and insoluble, they form the hard but mineral structures found in reptiles, birds, amphibians and mammals....
  • production of small proline-rich (SPRR) proteins and transglutaminase
    Transglutaminase

    Transglutaminases are a family of enzymes that catalyze the formation of a covalent bond between a free amine group and the gamma-carboxamid group of protein- or peptide-bound glutamine....
      which eventually form a cornified cell envelope beneath the plasma membrane
  • terminal differentiation
  • loss of nuclei and organelles, in the final stages of cornification metabolism ceases and the cells are completely filled by keratin


Sources: and .

See also

  • Keratin and Cornification
    Keratin

    Keratins are a family of fibrous protein; tough and insoluble, they form the hard but mineral structures found in reptiles, birds, amphibians and mammals....