Cilazapril

Cilazapril

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Encyclopedia
Cilazapril is a pyridazine
Pyridazine
Pyridazine is a heteroaromatic organic compound with the molecular formula C4H4N2, sometimes called 1,2-diazine. It contains a six-membered ring with two adjacent nitrogen atoms. It is a colorless liquid with a boiling point of 208 °C....

 angiotensin-converting enzyme
Angiotensin-converting enzyme
Angiotensin I-converting enzyme , an exopeptidase, is a circulating enzyme that participates in the body's renin-angiotensin system , which mediates extracellular volume , and arterial vasoconstriction...

 inhibitor (ACE inhibitor
ACE inhibitor
ACE inhibitors or angiotensin-converting enzyme inhibitors are a group of drugs used primarily for the treatment of hypertension and congestive heart failure...

) used for the treatment of hypertension
Hypertension
Hypertension or high blood pressure is a cardiac chronic medical condition in which the systemic arterial blood pressure is elevated. What that means is that the heart is having to work harder than it should to pump the blood around the body. Blood pressure involves two measurements, systolic and...

 and congestive heart failure
Congestive heart failure
Heart failure often called congestive heart failure is generally defined as the inability of the heart to supply sufficient blood flow to meet the needs of the body. Heart failure can cause a number of symptoms including shortness of breath, leg swelling, and exercise intolerance. The condition...

. It is branded as Inhibace in Canada, Zapril in New Zealand, Vascace and Dynorm in Europe. According to drugs.com (who have a partnership with the US Food & drug Administration) none of these are currently available in the United States
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...

as of May 2010.

Several stereo isomers exist of which, only one isomer is medically viable: cilazapril ((1S,9S)-9-[(2S)-2-yl]amin,-1-carbox)