Channelome
Encyclopedia
The channelome, sometimes "ion channelome", is an expression used to describe the complete set of ion channels expressed in a biological tissue
Tissue (biology)
Tissue is a cellular organizational level intermediate between cells and a complete organism. A tissue is an ensemble of cells, not necessarily identical, but from the same origin, that together carry out a specific function. These are called tissues because of their identical functioning...

 or organism. It is analogous to the genome
Genome
In modern molecular biology and genetics, the genome is the entirety of an organism's hereditary information. It is encoded either in DNA or, for many types of virus, in RNA. The genome includes both the genes and the non-coding sequences of the DNA/RNA....

, the metabolome
Metabolome
Metabolome refers to the complete set of small-molecule metabolites to be found within a biological sample, such as a single organism...

 (describing metabolites), the proteome
Proteome
The proteome is the entire set of proteins expressed by a genome, cell, tissue or organism. More specifically, it is the set of expressed proteins in a given type of cells or an organism at a given time under defined conditions. The term is a portmanteau of proteins and genome.The term has been...

 (describing general protein expression), the microbiome
Microbiome
A microbiome is the totality of microbes, their genetic elements , and environmental interactions in a defined environment. A defined environment could, for example, be the gut of a human being or a soil sample. Thus, microbiome usually includes microbiota and their complete genetic elements...

 etc. Characterization of the ion channelome can be performed by a wide variety of ion channel
Ion channel
Ion channels are pore-forming proteins that help establish and control the small voltage gradient across the plasma membrane of cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells...

 studying techniques ("channelomics
Channelomics
Channelomics is a newly emerging term for the study of membrane channels, that is; ion channels and porins . It is therefore a branch of physiology, biophysics and pharmacology. The term is not used widely and it is therefore perhaps questionable as to whether it will catch on...

") including patch clamp
Patch clamp
The patch clamp technique is a laboratory technique in electrophysiology that allows the study of single or multiple ion channels in cells. The technique can be applied to a wide variety of cells, but is especially useful in the study of excitable cells such as neurons, cardiomyocytes, muscle...

 electrophysiology
Electrophysiology
Electrophysiology is the study of the electrical properties of biological cells and tissues. It involves measurements of voltage change or electric current on a wide variety of scales from single ion channel proteins to whole organs like the heart...

, PCR and immunohistochemistry
Immunohistochemistry
Immunohistochemistry or IHC refers to the process of detecting antigens in cells of a tissue section by exploiting the principle of antibodies binding specifically to antigens in biological tissues. IHC takes its name from the roots "immuno," in reference to antibodies used in the procedure, and...

.
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