Carvallo's sign
Encyclopedia
Carvallo's sign is a clinical sign
Medical sign
A medical sign is an objective indication of some medical fact or characteristic that may be detected by a physician during a physical examination of a patient....

 found in patients with tricuspid regurgitation. The pansystolic murmur
Heart murmur
Murmurs are extra heart sounds that are produced as a result of turbulent blood flow that is sufficient to produce audible noise. Most murmurs can only be heard with the assistance of a stethoscope ....

 found in this condition becomes louder during inspiration
Inhalation
Inhalation is the movement of air from the external environment, through the air ways, and into the alveoli....

; this sign enables it to be distinguished from mitral regurgitation
Mitral regurgitation
Mitral regurgitation , mitral insufficiency or mitral incompetence is a disorder of the heart in which the mitral valve does not close properly when the heart pumps out blood. It is the abnormal leaking of blood from the left ventricle, through the mitral valve, and into the left atrium, when...

.

Pathophysiology

During inspiration, the venous blood flow into the right atrium
Right atrium
The right atrium is one of four chambers in the hearts of mammals and archosaurs...

 and ventricle
Right ventricle
The right ventricle is one of four chambers in the human heart. It receives deoxygenated blood from the right atrium via the tricuspid valve, and pumps it into the pulmonary artery via the pulmonary valve and pulmonary trunk....

 are increased, which increases the stroke volume of the right ventricle during systole. As a result, the leak of blood from the right ventricle into the right atrium is larger during inspiration, causing the murmur to become louder. During expiration, the leak of blood backwards through the tricuspid valve
Tricuspid valve
The tricuspid valve, or right atrioventricular valve, is on the right dorsal side of the mammalian heart, between the right atrium and the right ventricle. The normal tricuspid valve usually has three leaflets and three papillary muscles. They are connected to the papillary muscles by the chordae...

 is lessened, making the murmur more quiet. Conversely, the murmur of mitral regurgitation becomes louder during expiration due to the increase in venous return from the pulmonary vein
Pulmonary vein
The pulmonary veins are large blood vessels that carry blood from the lungs to the left atrium of the heart. In humans there are four pulmonary veins, two from each lung...

s to the left heart.
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