Cardiac neural crest
Encyclopedia
The cardiac neural crest complex is a form of neural crest
Neural crest
Neural crest cells are a transient, multipotent, migratory cell population unique to vertebrates that gives rise to a diverse cell lineage including melanocytes, craniofacial cartilage and bone, smooth muscle, peripheral and enteric neurons and glia....

.

The cardiac neural crest develops from the dorsal neural tube. It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart
Heart
The heart is a myogenic muscular organ found in all animals with a circulatory system , that is responsible for pumping blood throughout the blood vessels by repeated, rhythmic contractions...

, forming connective tissue that separates the great vessels of the heart.
Other Migration Locations:
  • Into the pharyngeal arches and Truncus arteriosus (embryology)
    Truncus arteriosus (embryology)
    The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The caudal end of the bulbus cordis gives rise to the smooth parts of the left and right ventricles...

    , forming the aorticopulmonary septum
    Aorticopulmonary septum
    The aorticopulmonary septum is developmentally formed from neural crest, specifically the cardiac...

     and the smooth muscle
    Smooth muscle
    Smooth muscle is an involuntary non-striated muscle. It is divided into two sub-groups; the single-unit and multiunit smooth muscle. Within single-unit smooth muscle tissues, the autonomic nervous system innervates a single cell within a sheet or bundle and the action potential is propagated by...

     of great arteries
    Great arteries
    Great arteries is a term used to refer collectively to the primary arteries of the heart, which include:* Pulmonary artery: the vessel that carries oxygen-depleted blood from the right ventricle to the lungs....

    .
  • Anterior of the aorta to become the four pre-aortic ganglia (celiac ganglion, superior mesenteric ganglion
    Superior mesenteric ganglion
    In the upper part of the superior mesenteric plexus close to the origin of the superior mesenteric artery is a ganglion, the superior mesenteric ganglion....

    , inferior mesenteric ganglion
    Inferior mesenteric ganglion
    The inferior mesenteric ganglion is a ganglion located near where the inferior mesenteric artery branches from the abdominal aorta....

     and aortical renal ganglia)


Notch2
NOTCH2
Neurogenic locus notch homolog protein 2 also known as notch 2 is a protein that in humans is encoded by the NOTCH2 gene.NOTCH2 is associated with Alagille syndrome and Hajdu–Cheney syndrome.- Function :Notch 2 a member of the notch family...

plays an important role in development.
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