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Burn (injury)

 
Burn (injury)

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Burn (injury)



 
 
A burn is a type of injury
Injury

Injury or bodily injury is damage or harm caused to the structure or Purpose of the body caused by an outside wiktionary:agent or force, which may be physical or chemical....
 that may be caused by heat
Heat

In physics and thermodynamics, heat is any transfer of energy from one body or thermodynamic system to another due to a difference in temperature....
, cold
Temperature

In physics, temperature is a physical property of a Physical system that underlies the common notions of hot and cold; something that feels hotter generally has the greater temperature....
, electricity
Electricity

Electricity is a general term that encompasses a variety of phenomena resulting from the presence and flow of electric charge. These include many easily recognizable phenomena such as lightning and static electricity, but in addition, less familiar concepts such as the electromagnetic field and electromagnetic induction....
, chemicals, light
Light

Light, or visible light, is electromagnetic radiation of a wavelength that is Visible spectrum to the human eye , or up to 380?750 nm. In the broader field of physics, light is sometimes used to refer to electromagnetic radiation of all wavelengths, whether visible or not....
, radiation
Radiation

In physics, radiation describes any process in which energy emitted by one body travels through a medium or through space, ultimately to be absorbed by another body....
, or friction
Friction

File:Friction alt.svgFriction is the force resisting the relative lateral motion of solid surfaces, fluid layers, or material elements in contact....
. Burns can be highly variable in terms of the tissue affected, the severity, and resultant complications. Muscle
MUSCLE

MUSCLE is public domain, multiple sequence alignment software for protein and nucleotide sequences.MUSCLE is integrated into UGENE bioinformatics tool as a plugin....
, bone
Bone

Bones are rigid organ that form part of the endoskeleton of vertebrates. They function to move, support, and protect the various organs of the body, produce red blood cell and white blood cells and store minerals....
, blood vessel
Blood vessel

The blood vessels are the part of the circulatory system that transport blood throughout the body. There are three major types of blood vessels: the artery, which carry the blood away from the heart, the capillary, which enable the actual exchange of water and chemicals between the blood and the tissues; and the veins, which carry blood from...
, and epidermal tissue
Epidermis (skin)

The epidermis is the outermost layer of the skin, composed of terminally differentiated stratified squamous epithelium, acting as the body's major barrier against an inhospitable environment....
 can all be damaged with subsequent pain due to profound injury to nerves. Depending on the location affected and the degree of severity, a burn victim may experience a wide number of potentially fatal complications including shock, infection
Infection

An infection is the detrimental colonization of a host organism by a foreign species. In an infection, the infecting organism seeks to utilize the host resources to multiply ....
, electrolyte imbalance and respiratory distress.






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Encyclopedia


A burn is a type of injury
Injury

Injury or bodily injury is damage or harm caused to the structure or Purpose of the body caused by an outside wiktionary:agent or force, which may be physical or chemical....
 that may be caused by heat
Heat

In physics and thermodynamics, heat is any transfer of energy from one body or thermodynamic system to another due to a difference in temperature....
, cold
Temperature

In physics, temperature is a physical property of a Physical system that underlies the common notions of hot and cold; something that feels hotter generally has the greater temperature....
, electricity
Electricity

Electricity is a general term that encompasses a variety of phenomena resulting from the presence and flow of electric charge. These include many easily recognizable phenomena such as lightning and static electricity, but in addition, less familiar concepts such as the electromagnetic field and electromagnetic induction....
, chemicals, light
Light

Light, or visible light, is electromagnetic radiation of a wavelength that is Visible spectrum to the human eye , or up to 380?750 nm. In the broader field of physics, light is sometimes used to refer to electromagnetic radiation of all wavelengths, whether visible or not....
, radiation
Radiation

In physics, radiation describes any process in which energy emitted by one body travels through a medium or through space, ultimately to be absorbed by another body....
, or friction
Friction

File:Friction alt.svgFriction is the force resisting the relative lateral motion of solid surfaces, fluid layers, or material elements in contact....
. Burns can be highly variable in terms of the tissue affected, the severity, and resultant complications. Muscle
MUSCLE

MUSCLE is public domain, multiple sequence alignment software for protein and nucleotide sequences.MUSCLE is integrated into UGENE bioinformatics tool as a plugin....
, bone
Bone

Bones are rigid organ that form part of the endoskeleton of vertebrates. They function to move, support, and protect the various organs of the body, produce red blood cell and white blood cells and store minerals....
, blood vessel
Blood vessel

The blood vessels are the part of the circulatory system that transport blood throughout the body. There are three major types of blood vessels: the artery, which carry the blood away from the heart, the capillary, which enable the actual exchange of water and chemicals between the blood and the tissues; and the veins, which carry blood from...
, and epidermal tissue
Epidermis (skin)

The epidermis is the outermost layer of the skin, composed of terminally differentiated stratified squamous epithelium, acting as the body's major barrier against an inhospitable environment....
 can all be damaged with subsequent pain due to profound injury to nerves. Depending on the location affected and the degree of severity, a burn victim may experience a wide number of potentially fatal complications including shock, infection
Infection

An infection is the detrimental colonization of a host organism by a foreign species. In an infection, the infecting organism seeks to utilize the host resources to multiply ....
, electrolyte imbalance and respiratory distress. Beyond physical complications, burns can also result in severe psychological and emotional distress due to scarring and deformity. It is generally accepted that a burn affecting more than one percent of the body surface, (approximately area of the casualty's palm) should be assessed by a medical practitioner.

Classification

The traditional system of classifying burns categorizes them as first-, second-, or third-degree. Most burns are first- to third-degree, with the higher-degree burns typically being used to classify burns postmortem. The following are brief descriptions of these classes:

This system is however being replaced by one reflecting the need for surgical intervention. The burn depths are described as either superficial, superficial partial-thickness, deep partial-thickness, or full-thickness.

By degree


  • First-degree burns are usually limited to redness (erythema
    Erythema

    Erythema is redness of the skin caused by capillary congestion....
    ), a white plaque and minor pain
    Pain

    Pain, in the sense of physical pain, is a typical sensory experience that may be described as the unpleasant awareness of a noxious stimulus or bodily harm....
     at the site of injury. These burns involve only the epidermis
    Epidermis (skin)

    The epidermis is the outermost layer of the skin, composed of terminally differentiated stratified squamous epithelium, acting as the body's major barrier against an inhospitable environment....
    . Sunburns can be included as first degree burns.
  • Second-degree burns manifest as erythema with superficial blister
    Blister

    A blister is a small pocket of fluid within the upper layers of the skin, typically caused by forceful rubbing , burning, freezing, chemical exposure or infection....
    ing of the skin, and can involve more or less pain depending on the level of nerve
    Nerve

    A nerve is an enclosed, cable-like bundle of Peripheral nervous system axons . A nerve provides a common pathway for the electrochemical nerve impulses that are transmitted along each of the axons....
     involvement. Second-degree burns involve the superficial (papillary) dermis
    Dermis

    File:EpidermisPainted.svgThe dermis is a layer of skin between the epidermis_ and subcutaneous tissues, and is composed of two layers, the papillary_dermis and reticular dermis....
     and may also involve the deep (reticular) dermis layer.* Third-degree burns occur when the epidermis is lost with damage to the subcutaneous tissue. Burn victims will exhibit charring and extreme damage of the epidermis
    Epidermis

    Epidermis may refer to:* Epidermis , in plants, the outermost layer of cells covering the leaves and young parts of a plant* Epidermis , in vertebrates, the outermost layer of the skin...
    , and sometimes hard eschar
    Eschar

    From the Greek word eschara an eschar is a slough or piece of necrosis that is cast off from the surface of the skin, particularly after a burn , but also seen in gangrene, Ulcer , mycosis, Brown recluse spider, and late exposure to anthrax....
     will be present. Third-degree burns result in scarring and victims will also exhibit the loss of hair shafts and keratin. These burns may require grafting
    Medical grafting

    In medicine, grafting is a surgical procedure to Organ transplant Biological tissue without a vascular system. The implanted tissue must obtain a blood supply from the new vascular bed or otherwise die....
    .
  • Fourth-degree burns damage muscle, tendon, and ligament tissue, thus result in charring and catastrophic damage of the hypodermis. In some instances the hypodermis tissue may be partially or completely burned away as well as this may result in a condition called compartment syndrome
    Compartment syndrome

    Compartment syndrome is an acute medical problem following injury, surgery or in most cases repetitive and extensive muscle use, in which increased pressure within a confined space in the body impairs perfusion....
    , which threatens both the life and the limb of the patient. Grafting is required if the burn does not prove to be fatal.


Other classifications

A newer classification of "Superficial Thickness", "Partial Thickness" (which is divided into superficial and deep categories) and "Full Thickness" relates more precisely to the epidermis, dermis and subcutaneous layers of skin and is used to guide treatment and predict outcome.

Table 1. A description of the traditional and current classifications of burns.
Nomenclature Traditional nomenclature Depth Clinical findings
Superficial thicknessFirst-degreeEpidermis involvementErythema
Erythema

Erythema is redness of the skin caused by capillary congestion....
, minor pain, lack of blisters
Partial thickness — superficialSecond-degreeSuperficial (papillary) dermis
Dermis

File:EpidermisPainted.svgThe dermis is a layer of skin between the epidermis_ and subcutaneous tissues, and is composed of two layers, the papillary_dermis and reticular dermis....
Blisters, clear fluid, and pain
Partial thickness — deepSecond-degreeDeep (reticular) dermisWhiter appearance
Full thicknessThird- or Fourth-degree Dermis and underlying tissue and possibly fascia
Fascia

Fascia , pl. fas?ci?ae , adj. fascial is the soft tissue component of the connective tissue system that permeates the human body....
, bone
Bone

Bones are rigid organ that form part of the endoskeleton of vertebrates. They function to move, support, and protect the various organs of the body, produce red blood cell and white blood cells and store minerals....
, or muscle
MUSCLE

MUSCLE is public domain, multiple sequence alignment software for protein and nucleotide sequences.MUSCLE is integrated into UGENE bioinformatics tool as a plugin....
Hard, leather-like eschar, purple fluid, no sensation (insensate)


An even simpler, more accurate and more descriptive classification is epidermal, dermal and full thickness. Dermal injuries are subdivided into superficial, mid and deep.

Burns can also be assessed in terms of total body surface area (TBSA), which is the percentage affected by partial thickness or full thickness burns (superficial thickness burns are not counted). The rule of nines is used as a quick and useful way to estimate the affected TBSA.

Causes of burns


Burns are caused by a wide variety of substances and external sources such as exposure to chemicals, friction, electricity, radiation, and extreme temperatures, both hot and cold.

Most
chemicals that cause severe chemical burns are strong acid
Acid

An acid is traditionally considered any chemical compound that, when dissolved in water, gives a solution with a hydrogen ion Activity greater than in pure water, i.e....
s or bases
Base (chemistry)

In chemistry, a base is most commonly thought of as an aqueous substance that can accept protons. A base is also often referred to as an alkali if OH- ions are involved....
. Chemical burns are usually caused by caustic
Corrosive

A corrosive substance is one that will destroy or irreversibly damage another substance with which it comes in contact. The main hazards to people include damage to eyes, skin and tissue under the skin, but inhalation or ingestion of a corrosive substance can damage the respiratory and gastrointestinal tracts....
 chemical compounds, such as sodium hydroxide
Sodium hydroxide

Sodium hydroxide , also known as lye, caustic soda and sodium hydrate, is a caustic metallic Base . Sodium hydroxide forms a strong alkaline solution when dissolved in a solvent such as water, however, only the hydroxide ion is basic....
, silver nitrate
Silver nitrate

Silver nitrate, also known as lunar caustic, is a soluble chemical compound with chemical formula silverNitrogenOxygen3. This compound is a versatile precursor to many other silver compounds, such as those used in photography....
, and more serious compounds (such as sulfuric acid
Sulfuric acid

Sulfuric acid, hydrogen2sulfuroxygen4, is a strong mineral acid. It is soluble in water at all concentrations. Sulfuric acid has many applications, and is one of the top products of the chemical industry....
 and Nitric acid
Nitric acid

Nitric acid , also known as aqua fortis and spirit of nitre, is a highly corrosion and toxic strong acid that can cause severe burns....
). Hydrofluoric acid
Hydrofluoric acid

Hydrofluoric acid is a solution of hydrogen fluoride in water. While it is extremely corrosive and dangerous to handle, it is technically a weak acid....
 can cause damage down to the bone and its burns are sometimes not immediately evident.

Electrical burns are caused by an exogenous electric shock
Electric shock

An electric shock can occur upon contact of a human's body with any source of voltage high enough to cause sufficient Electric current through the muscles or hair....
. Common causes of electrical burns include workplace injuries
Occupational safety and health

Occupational safety and health is a Interdisciplinarity area concerned with protecting the safety, health and quality of life of people engaged in Employment....
 or being defibrillated or cardioverted
Defibrillation

Defibrillation is the definitive treatment for the life-threatening cardiac arrhythmias, ventricular fibrillation and ventricular tachycardia....
 without a conductive gel. Lightning
Lightning

File:Blesk.jpgLightning is an Earth's atmosphere discharge of electricity usually accompanied by thunder, which typically occurs during thunderstorms, and sometimes during volcano or dust storms....
 is a rare cause of electrical burns. The internal injuries sustained may be disproportionate to the size of the burns seen, and the extent of the damage is not always obvious. Such injuries may lead to cardiac arrhythmias, cardiac arrest
Cardiac arrest

A cardiac arrest, also known as cardiopulmonary arrest or circulatory arrest, is the abrupt cessation of normal circulation of the blood due to failure of the heart to contract effectively during Systole ....
, and unexpected falls with resultant fractures.

Radiation burns are caused by protracted exposure to UV light (as from the sun), tanning booths, radiation therapy
Radiation therapy

Radiation therapy is the medicine use of ionizing radiation as part of cancer oncology to control malignant cell s . Radiotherapy may be used for curative or Adjuvant chemotherapy cancer treatment....
 (as patients who are undergoing cancer
Cancer

Cancer is a class of diseases in which a group of cell display uncontrolled growth , invasion , and sometimes metastasis . These three malignant properties of cancers differentiate them from benign tumors, which are self-limited, do not invade or metastasize....
 therapy), sunlamps, and X-rays. By far the most common burn associated with radiation is sun exposure, specifically two wavelengths of light UVA
Ultraviolet

Ultraviolet light is electromagnetic radiation with a wavelength shorter than that of visible light, but longer than x-rays, in the range 400 nanometer to 10 nm, and energies from 3 Electron volt to 124 eV....
, and UVB, the latter being more dangerous. Tanning booths also emit these wavelengths and may cause similar damage to the skin such as irritation, redness, swelling, and inflammation
Inflammation

Inflammation is the complex biological response of Blood vessel tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. It is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue....
. More severe cases of sun burn result in what is known as sun poisoning.

Scalding


Scaldburn
Scalding is caused by hot liquids or gases, most commonly occurring from exposure to high temperature tap water
Tap water

Tap water is part of indoor plumbing, which became available in the late 19th century and common in the mid-20th century.The provision of tap water requires a massive infrastructure of piping, pumps, and water purification works....
. A blister is a "bubble" in the skin filled with serous fluid as part of the body's reaction to the heat and nerve damage. Steam is a common gas that causes scalds. The injury is usually regional and usually does not cause death. More damage can be caused if hot liquids enter an orifice. However, deaths have occurred in more unusual circumstances, such as when people have accidentally broken a steam pipe. The demographics that are of the highest risk to suffering from scalding are young children, with their delicate skin, and the elderly over 65 years of age.

Cold burn

Frostbitten Hands
A
cold burn (compare frostbite
Frostbite

Frostbite is the medical condition wherein localized damage is caused to skin and other biological tissue due to extreme cold.Frostbite is most likely to happen in body parts farthest from the heart and those with large exposed areas....
) is a kind of burn which arises when the skin is in contact with a low-temperature object. They can be caused by prolonged contact with moderately cold objects (snow
Snow

Snow is a type of precipitation in the form of crystalline water ice, consisting of a multitude of snowflakes that fall from clouds. The process of this precipitation is called snowfall....
 and cold air
AIR

Air is the part of Earth's atmosphere that humans breath and as such Air .Air may also refer to:...
 for instance) or brief contact with very cold objects such as dry ice
Dry ice

Dry ice is solid carbon dioxide. It is commonly used as a versatile cooling agent.Dry ice Sublimation , changing directly to a gas at atmospheric pressure....
, liquid helium
Liquid helium

Helium exists in liquid form only at very low temperatures. The boiling point and critical point depend on the isotope of the helium; see the table below for values....
, liquid nitrogen
Liquid nitrogen

Liquid nitrogen is a liquefied atmospheric gas produced industrially in large quantities by fractional distillation of liquid air. It is pure nitrogen in a liquid state at very low temperature....
, liquid discharged from an upside-down gas duster, or other refrigerant
Refrigerant

A refrigerant is a compound used in a heat engine that undergoes a phase change from a gas to a liquid and back. The two main uses of refrigerants are refrigerators/freezers and air conditioners ....
s. In such a case, the heat
Heat

In physics and thermodynamics, heat is any transfer of energy from one body or thermodynamic system to another due to a difference in temperature....
 transfers from the skin and organs to the external cold object.

Hot tar burn

Polyoxyethylene sorbitan in Neosporin ointment or sunflower oil are excellent dispersing agents that facilitate the removal of hot tar from burns.

Management

A local anesthetic
Local anesthetic

A local anesthetic is a medication that causes reversible local anesthesia and a loss of nociception. When it is used on specific nerve pathways , effects such as analgesia and paralysis can be achieved....
 is usually sufficient in managing pain of minor first-degree and second-degree burns; also Aloe vera
Aloe vera

Aloe vera, also known as the Medicinal Aloe, is a species of succulent plant that probably originated in northern Africa. The species does not have any naturally occurring populations, although closely related Aloes do occur in northern Africa....
 sap can be used to heal the burn area. However, systemic anti-inflammatory drugs such as naproxen
Naproxen

Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of moderate to severe pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and the treatment of primary dysmenorr...
 or ibuprofen
Ibuprofen

Ibuprofen is a non-steroidal anti-inflammatory drug originally marketed as Brufen, and since then under various other trademarks , most notably Nurofen, Advil and Motrin....
 may be effective in mitigating pain and swelling. Additionally, topical antibiotics such as Mycitracin are useful in preventing infection to the damaged area. Lidocaine
Lidocaine

Lidocaine or lignocaine is a common local anesthetic and antiarrhythmic agent drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic, and in minor surgery....
 can be administered to the spot of injury and will generally negate most of the pain. Regardless of the cause, the first step in managing a person with a burn is to stop the burning process at the source. For instance, with dry powder burns, the powder should be brushed off first. With other burns, such as those caused by exposure to chemicals, the affected area should be rinsed thoroughly with a large amount of clean water to remove the caustic agent and any foreign bodies
Foreign body

In physiology, a foreign body is any object originating outside the body. In machinery, it can mean any unwanted intruding object....
. Cold water should not be applied to a person with extensive burns, however, as it may compromise the burn victim's temperature status.

If the patient was involved in a fire accident, then it must be assumed that he or she has sustained inhalation injury until proven otherwise, and treatment should be managed accordingly. At this stage of management, it is also critical to assess the airway status. Any hint of burn injury to the lung
Lung

The lung is the essential respiration organ in air-breathing animals, including most tetrapods, a few fish and a few snails. In mammals and the more complex life forms, the two lungs are located in the chest on either side of the heart....
s (e.g. through smoke inhalation
Smoke inhalation

Smoke inhalation is the primary cause of death in victims of indoor fires.Smoke inhalation injury refers to injury due to inhalation or exposure to hot gaseous products of combustion....
) is considered a medical emergency
Medical emergency

A medical emergency is an injury or illness that is Acute and poses an immediate risk to a person's life or long term health. These emergencies may require assistance from another person, who should ideally be suitably qualified to do so, although some of these emergencies can be dealt with by the victim themselves....
.

Once the burning process has been stopped, the patient should be volume resuscitated according to the Parkland formula (4ml lactated ringers x TBSA % burned x pt. weight kg.), since such injuries can disturb a person's osmotic balance. This formula dictates the amount of Lactated Ringer's solution
Lactated Ringer's solution

Lactated Ringer's solution is a solution that is Tonicity with blood and intended for intravenous therapy. Veterinary administration may also be subcutaneous....
 (Hartmann's solution
Hartmann's Solution

Hartmann's solution or Compound Sodium Lactate is a solution that is Tonicity with blood and intended for intravenous therapy.Hartmann's solution is abbreviated as "CSL"....
) to deliver in the first twenty four hours after time of injury. This formula excludes first and most second degree burns. Half of the fluid should be given in the first eight hours post injury and the rest in the subsequent sixteen hours. Inhalation injuries in conjunction with thermal burns initially require up to 40-50% more fluid. The formula is a guide only and infusions must be tailored to the urine
Urine

Urine is a liquid waste product of the body secreted by the kidneys by a process of filtration from blood called urination and excreted through the urethra....
 output and central venous pressure
Central venous pressure

Central venous pressure describes the pressure of blood in the thoracic vena cava, near the right atrium of the heart. CVP reflects the amount of blood returning to the heart and the ability of the heart to pump the blood into the arterial system....
. Inadequate fluid resuscitation causes renal failure
Renal failure

Renal failure or kidney failure is a situation in which the kidneys fail to function adequately. It is divided in acute and chronic forms; either form may be due to a large number of other medical problems....
 and death
Death

Death is the permanent termination of the biological functions that define a life organism. It refers to both a particular event and to the condition that results thereby....
. Adequate pain management
Pain management

Pain management is the medicine discipline concerned with the relief of pain....
, including administration of opioid
Opioid

An opioid is a chemical substance that has a morphine-like action in the body. The main use is for analgesia. These agents work by binding to opioid receptors, which are found principally in the central nervous system and the gastrointestinal tract....
 analgesics and sometimes other medication (e.g. ketamine
Ketamine

Ketamine is a drug used in human and veterinary medicine developed by Parke-Davis in 1962. Its hydrochloride salt is sold as Ketanest, Ketaset, and Ketalar....
, tranquilizers or general anesthetics), is important to alleviate the severe distress from the burns.

Hyperbaric oxygenation has not been shown to be a useful adjunct to traditional treatments.

To help ease the suffering of a burn victim, they may be placed in a special burn recovery bed
Burn recovery bed

A burn recovery bed or burn bed is a special type of bed designed for hospital patients who have suffered severe second degree burn across large portions of their body....
 which evenly distributes body weight and helps to prevent painful pressure points and bed sores. Survival and outcome of severe burn injuries is remarkably improved if the patient is treated in a specialized burn center/unit rather than a hospital. Serious burns, especially if they cover large areas of the body, can result in death.

Reactions and complications

Following a major burn injury heart rate and peripheral vascular resistance increase. This is due to the release of catecholamines from injured tissues, and the relative hypovolemia
Hypovolemia

In physiology and medicine, hypovolemia is a state of decreased blood volume; more specifically, decrease in volume of blood plasma. Volumetric thirst can be caused by a number of things including bleeding and diarrhea....
 that occurs from fluid volume shifts. Initially cardiac output
Cardiac output

Cardiac output is the volume of blood being pumped by the heart, in particular by a ventricle in a minute. This is measured in dm3 min-1 ....
 decreases. At approximately 24 hours after burn injuries (for patients receiving fluid resuscitation) cardiac output
Cardiac output

Cardiac output is the volume of blood being pumped by the heart, in particular by a ventricle in a minute. This is measured in dm3 min-1 ....
 returns to normal, then increases to meet the hypermetabolic needs of the body.

Infection
Infection

An infection is the detrimental colonization of a host organism by a foreign species. In an infection, the infecting organism seeks to utilize the host resources to multiply ....
 is a major complication of burns. Infection is linked to impaired resistance from disruption of the skin's mechanical integrity and generalized immune suppression. The skin barrier is replaced by eschar
Eschar

From the Greek word eschara an eschar is a slough or piece of necrosis that is cast off from the surface of the skin, particularly after a burn , but also seen in gangrene, Ulcer , mycosis, Brown recluse spider, and late exposure to anthrax....
. This moist, protein rich avascular environment encourages microbial growth. Migration of immune cells is hampered, and there is a release of intermediaries that impede the immune response. Eschar
Eschar

From the Greek word eschara an eschar is a slough or piece of necrosis that is cast off from the surface of the skin, particularly after a burn , but also seen in gangrene, Ulcer , mycosis, Brown recluse spider, and late exposure to anthrax....
 also restricts distribution of systemically administered antibiotics because of its avascularity.

Risk factors of burn wound infection include: - burn > 30% TBS - full-thickness burn - extremes in age (very young, very old) - preexisting disease e.g. diabetes - virulence and antibiotic resistance of colonizing organism - failed skin graft - improper initial burn wound care - prolonged open burn wound

Burn wounds are prone to tetanus
Tetanus

Tetanus, also called lockjaw, is a medical condition characterized by a prolonged contraction of skeletal muscle fibers. The primary symptoms are caused by tetanospasmin, a neurotoxin produced by the Gram-positive, Anaerobic organism Clostridium tetani....
. A tetanus booster shot is required if individual has not been immunized within the last 5 years.

Circumferential burns of extremities may compromise circulation. Elevation of limb may help to prevent dependent edema. An Escharotomy
Escharotomy

An escharotomy is a surgical procedure used to treat full thickness circumferential burn . Since full thickness burns are characterized by tough, leathery eschar, an escharotomy is used primarily to combat compartment syndrome....
 may be required.

Acute Tubular Necrosis of the kidneys can be caused by myoglobin
Myoglobin

Myoglobin is a Tertiary structure globular protein of 153 amino acids, containing a heme prosthetic group in the center around which the remaining apoprotein folds....
 and hemoglobin
Hemoglobin

Hemoglobin is the iron-containing oxygen-transport metalloprotein in the red blood cells of vertebrates, and the tissues of some invertebrates....
 released from damaged muscles and red blood cells. This is common in electrical burns or crush injuries where adequate fluid resuscitation has not been achieved.

See also



External links