BOLL
Encyclopedia
Protein boule-like is a protein
that in humans is encoded by the BOLL gene
.
development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ
(deleted in azoospermia) or DAZL
(deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia
). Histological studies demonstrated that the primary defect is at the meiotic
G2
/ M
transition. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
The boule-like protein appears to be ubiquitously expressed in males of all animal species, except in the most primitive trichoplax
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the BOLL gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Function
This gene belongs to the DAZ gene family required for germ cellGerm cell
A germ cell is any biological cell that gives rise to the gametes of an organism that reproduces sexually. In many animals, the germ cells originate near the gut of an embryo and migrate to the developing gonads. There, they undergo cell division of two types, mitosis and meiosis, followed by...
development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ
DAZ1
Deleted in azoospermia 1, also known as DAZ1, is a protein which in humans is encoded by the DAZ1 gene.- Function :This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor . Its expression is restricted to pre-meiotic germ cells, particularly in...
(deleted in azoospermia) or DAZL
DAZL
Deleted in azoospermia-like is a protein that in humans is encoded by the DAZL gene.-Further reading:...
(deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia
Azoospermia
Azoospermia is the medical condition of a male not having any measurable level of sperm in his semen. It is associated with very low levels of fertility or even sterility, but many forms are amenable to medical treatment...
). Histological studies demonstrated that the primary defect is at the meiotic
Meiosis
Meiosis is a special type of cell division necessary for sexual reproduction. The cells produced by meiosis are gametes or spores. The animals' gametes are called sperm and egg cells....
G2
G2 phase
G2 phase is the 3rd and final subphase of Interphase in the cell cycle directly preceding Mitosis. It follows the successful completion of S phase, during which the cell’s DNA is replicated...
/ M
Mitosis
Mitosis is the process by which a eukaryotic cell separates the chromosomes in its cell nucleus into two identical sets, in two separate nuclei. It is generally followed immediately by cytokinesis, which divides the nuclei, cytoplasm, organelles and cell membrane into two cells containing roughly...
transition. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
The boule-like protein appears to be ubiquitously expressed in males of all animal species, except in the most primitive trichoplax
Trichoplax
The Placozoa are a basal form of invertebrate. They are the simplest in structure of all non-parasitic multicellular animals . They are generally classified as a single species, Trichoplax adhaerens, although there is enough genetic diversity that it is likely that there are multiple,...
.