BEACOPP
Encyclopedia
BEACOPP is a chemotherapy regimen for treatment of Hodgkin's lymphoma
in Stages > II developed by the German Hodgkin Study Group. Patients typically receive treatment in cycles of 21 days with no drugs given on days 16-21. There also exists a more intensive regimen with cycles of 14 days. Usually a therapy consists of eight, sometimes six cycles.
In some countries BEACOPP still is experimental, in others (e.g. Germany
and Austria
) it is a standard therapy. In the United States, ABVD
(or Stanford V
) is generally given instead, because BEACOPP is thought to induce more secondary neoplasias (such as leukemias) . This has not been proven after 10 years of experience in other countries. Some consider that the BEACOPP regimen is not generally given for cost reasons; it is indeed more expensive as it requires G-CSF support. However, BEACOPP delivers approximately 10-15% more cures in advanced Hodgkin's disease (IIB+risk factors or stages III and IV).
m² = body surface
i.v. = intravenous
BEACOPP basic:
BEACOPP escalated:
Hodgkin's lymphoma
Hodgkin's lymphoma, previously known as Hodgkin's disease, is a type of lymphoma, which is a cancer originating from white blood cells called lymphocytes...
in Stages > II developed by the German Hodgkin Study Group. Patients typically receive treatment in cycles of 21 days with no drugs given on days 16-21. There also exists a more intensive regimen with cycles of 14 days. Usually a therapy consists of eight, sometimes six cycles.
In some countries BEACOPP still is experimental, in others (e.g. Germany
Germany
Germany , officially the Federal Republic of Germany , is a federal parliamentary republic in Europe. The country consists of 16 states while the capital and largest city is Berlin. Germany covers an area of 357,021 km2 and has a largely temperate seasonal climate...
and Austria
Austria
Austria , officially the Republic of Austria , is a landlocked country of roughly 8.4 million people in Central Europe. It is bordered by the Czech Republic and Germany to the north, Slovakia and Hungary to the east, Slovenia and Italy to the south, and Switzerland and Liechtenstein to the...
) it is a standard therapy. In the United States, ABVD
ABVD
ABVD is a chemotherapy regimen used in the first-line treatment of Hodgkin lymphoma, supplanting the older MOPP protocol. It consists of concurrent treatment with the chemotherapy drugs:*Adriamycin *bleomycin...
(or Stanford V
Stanford V
Stanford V is a chemotherapy regimen intended as a first line treatment for Hodgkin's lymphoma...
) is generally given instead, because BEACOPP is thought to induce more secondary neoplasias (such as leukemias) . This has not been proven after 10 years of experience in other countries. Some consider that the BEACOPP regimen is not generally given for cost reasons; it is indeed more expensive as it requires G-CSF support. However, BEACOPP delivers approximately 10-15% more cures in advanced Hodgkin's disease (IIB+risk factors or stages III and IV).
m² = body surface
i.v. = intravenous
BEACOPP basic:
| (B)leomycin Bleomycin Bleomycin is a glycopeptide antibiotic produced by the bacterium Streptomyces verticillus. Bleomycin refers to a family of structurally related compounds. When used as an anticancer agent, the chemotherapeutical forms are primarily bleomycin A2 and B2. It works by causing breaks in DNA... |
10 mg/m² | i.v. | day 8 |
| (E)toposide Etoposide Etoposide phosphate is an anti-cancer agent. It is known in the laboratory as a topoisomerase poison. Etoposide is often incorrectly referred to as a topoisomerase inhibitor in order to avoid using the term "poison" in a clinical setting... |
100 mg/m² | i.v. | day 1-3 |
| (A)driamycin | 25 mg/m² | i.v. | day 1 |
| (C)yclophosphamide Cyclophosphamide Cyclophosphamide , also known as cytophosphane, is a nitrogen mustard alkylating agent, from the oxazophorines group.... |
650 mg/m² | (i.v.) | day 1 |
| Vincristin(=(O)ncovin) Vincristine Vincristine , formally known as leurocristine, sometimes abbreviated "VCR", is a vinca alkaloid from the Catharanthus roseus , formerly Vinca rosea and hence its name. It is a mitotic inhibitor, and is used in cancer chemotherapy.-Mechanism:Tubulin is a structural protein that polymerizes to... |
1,4 mg/m² (max 2 mg) | i.v. | day 8 |
| (P)rocarbazine Procarbazine Procarbazine Procarbazine Procarbazine (Matulane (US), Natulan (Canada), Indicarb (India) is an antineoplastic chemotherapy drug for the treatment of Hodgkin's lymphoma and certain brain cancers (such as Glioblastoma multiforme). It is a member of a group of medicines called alkylating agents. It... |
100 mg/m² | orally | day 1-7 |
| (P)rednisone Prednisone Prednisone is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant drug. It is used to treat certain inflammatory diseases and some types of cancer, but has significant adverse effects... |
40 mg/m² | orally | day 1-14 |
BEACOPP escalated:
| Bleomycin | 10 mg/m² | i.v. | day 8 |
| Etoposide | 200 mg/m² | i.v. | day 1-3 |
| Adriamycin (=Doxorubicin) | 35 mg/m² | i.v. | day 1 |
| Cyclophosphamide | 1250 mg/m² KO/day | i.v. | day 1 |
| Vincristine | 1,4 mg/m² (max 2 mg) | i.v. | day 8 |
| Procarbazine | 100 mg/m² | orally | day 1-7 |
| Prednisone | 40 mg/m² | orally | day 1-14 |