The Autopista A-49 is a major highway in Andalusia

Andalusia

Andalusia is the most populous and the second largest in area of the autonomous communities of Spain. The Andalusian autonomous community is officially recognised as a nationality of Spain. The territory is divided into eight provinces: Huelva, Seville, Cádiz, Córdoba, Málaga, Jaén, Granada and...

, Spain

Spain

Spain , officially the Kingdom of Spain languages]] under the European Charter for Regional or Minority Languages. In each of these, Spain's official name is as follows:;;;;;;), is a country and member state of the European Union located in southwestern Europe on the Iberian Peninsula...

. It connects Seville

Seville

Seville is the artistic, historic, cultural, and financial capital of southern Spain. It is the capital of the autonomous community of Andalusia and of the province of Seville. It is situated on the plain of the River Guadalquivir, with an average elevation of above sea level...

 with the border of Portugal

Portugal

Portugal , officially the Portuguese Republic is a country situated in southwestern Europe on the Iberian Peninsula. Portugal is the westernmost country of Europe, and is bordered by the Atlantic Ocean to the West and South and by Spain to the North and East. The Atlantic archipelagos of the...

. It is also European route E1.

It starts on the ring road of Seville

Seville

Seville is the artistic, historic, cultural, and financial capital of southern Spain. It is the capital of the autonomous community of Andalusia and of the province of Seville. It is situated on the plain of the River Guadalquivir, with an average elevation of above sea level...

 and heads east with a spur south A-483 to Almonte, the Costa de la Luz

Costa de la Luz

The Costa de la Luz is a section of the Andalusian coast in Spain facing the Atlantic; it extends from Tarifa in the south, along the coasts of the Province of Cádiz and the Province of Huelva, to the mouth of the Guadiana River....

 and the Parque Nacional de Doňana. The road crosses the Rio Tinto and Rio Odiel north of Huelva

Huelva

Huelva is a city in southwestern Spain, the capital of the province of Huelva in the autonomous region of Andalusia. It is located along the Gulf of Cadiz coast, at the confluence of the Odiel and Tinto rivers. According to the 2010 census, the city has a population of 149,410 inhabitants. The...

. The road crosses the border 133 km west of Seville on a bridge over the Rio Guadiana.